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Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2014, Volume 278, Issue 3, pp. 238 - 248
Pharmacokinetic drug resistance is a serious obstacle that emerges during cancer chemotherapy. In this study, we investigated the possible role of aldo-keto... 
Anthracyclines | Aldo-keto reductase 1C3 | Drug resistance | Metabolism | Enzyme induction | DOXORUBICIN | TUMOR-CELLS | INDUCTION | STEROID-HORMONE | DAUNORUBICIN | ENDOMETRIAL CANCER | BREAST-CANCER | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MCF-7 CELLS | Antibiotics, Antineoplastic - pharmacology | Humans | Daunorubicin - agonists | Daunorubicin - pharmacology | Idarubicin - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Anthracyclines - agonists | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Anthracyclines - pharmacology | Biotransformation | Anthracyclines - metabolism | Enzyme Induction - drug effects | 3-Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Neoplasm Proteins - genetics | Antibiotics, Antineoplastic - agonists | Carcinoma - drug therapy | Idarubicin - metabolism | Recombinant Proteins - metabolism | Cell Survival - drug effects | Oxidation-Reduction | Flavanones - pharmacology | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Drug Synergism | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Antibiotics, Antineoplastic - metabolism | Idarubicin - agonists | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Chemotherapy | Cancer cells | Cancer | Index Medicus | CARBONYLS | METABOLISM | NEOPLASMS | ENZYMES | DRUGS | TOXICITY | INCUBATION | 60 APPLIED LIFE SCIENCES | ENZYME INDUCTION | CHEMOTHERAPY
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2013, Volume 132, Issue 2, pp. 474 - 482
Abstract Objective Over-expression of the aldo-keto reductase family 1 member C3 (AKR1C3) has been demonstrated in many human cancers. Lipocalin 2 (LCN2) is... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Lipocalin 2 | Cancer of the uterine cervix | Metastasis | Aldo-keto reductase family 1 member C3 | Matrix metalloproteinase-2 | RADICAL HYSTERECTOMY | PROGNOSTIC-FACTORS | GELATINASE-ASSOCIATED LIPOCALIN | HUMAN-PAPILLOMAVIRUS | OVARIAN-CANCER | DIHYDRODIOL DEHYDROGENASE | OBSTETRICS & GYNECOLOGY | BREAST-CANCER | LUNG-CANCER | ONCOLOGY | PROSTATE-CANCER | SQUAMOUS-CELL CARCINOMA | Lipocalins - biosynthesis | Hydroxyprostaglandin Dehydrogenases - deficiency | Prognosis | Humans | Uterine Cervical Neoplasms - pathology | Acute-Phase Proteins - genetics | Proto-Oncogene Proteins - biosynthesis | Hydroxyprostaglandin Dehydrogenases - metabolism | Cell Movement - physiology | Neoplasm Recurrence, Local - pathology | RNA, Messenger - biosynthesis | Transfection | Uterine Cervical Neoplasms - metabolism | Lipocalins - genetics | HEK293 Cells | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Matrix Metalloproteinase 2 - biosynthesis | 3-Hydroxysteroid Dehydrogenases - deficiency | Cytoskeleton - pathology | Neoplasm Recurrence, Local - metabolism | RNA, Messenger - genetics | Cytoskeleton - genetics | Gene Silencing | Proto-Oncogene Proteins - genetics | Uterine Cervical Neoplasms - genetics | Disease Progression | Hydroxyprostaglandin Dehydrogenases - genetics | Matrix Metalloproteinase 2 - genetics | Aldo-Keto Reductase Family 1 Member C3 | Lipocalin-2 | Cell Line, Tumor | Cytoskeleton - metabolism | Neoplasm Recurrence, Local - genetics | HeLa Cells | 3-Hydroxysteroid Dehydrogenases - genetics | Acute-Phase Proteins - biosynthesis | Development and progression | Cervical cancer | Cancer | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 3, pp. 335 - 344
Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level.... 
Aldo-keto reductase (AKR) | Retinaldehyde | Proliferation | Retinoic acid | Retinol | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | proliferation | BIOCHEMISTRY & MOLECULAR BIOLOGY | aldo-keto reductase (AKR) | retinaldehyde | STEROID-HORMONE | DIHYDRODIOL DEHYDROGENASE | retinol | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | BREAST-CANCER CELLS | retinoic acid | METABOLISM | REVEALS ROLES | MCF-7 CELLS | PROSTAGLANDIN-F SYNTHASE | Vitamin A - pharmacology | Vitamin A - chemistry | Cell Proliferation | Hydroxysteroid Dehydrogenases - chemistry | Humans | Transcriptional Activation | 20-Hydroxysteroid Dehydrogenases - chemistry | Retinaldehyde - chemistry | Substrate Specificity | Hydroxyprostaglandin Dehydrogenases - metabolism | Oxidoreductases - chemistry | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Retinaldehyde - physiology | Hydroxyprostaglandin Dehydrogenases - chemistry | Binding Sites | Mutagenesis, Site-Directed | Oxidoreductases - metabolism | Models, Molecular | Receptors, Retinoic Acid - antagonists & inhibitors | Receptors, Retinoic Acid - metabolism | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Vitamin A - physiology | Retinaldehyde - pharmacology | Cell Line, Tumor | Protein Binding | 3-Hydroxysteroid Dehydrogenases - chemistry | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Amino Acid Substitution | Index Medicus
Journal Article
Journal Article
BMC Pregnancy and Childbirth, ISSN 1471-2393, 07/2014, Volume 14, Issue 1, pp. 241 - 241
Background: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective... 
Pregnancy | Parturition | Inflammation | Uterus | RIBONUCLEIC-ACID ABUNDANCE | TROPHOBLAST CELLS | ENDOPEROXIDE-H SYNTHASE-1 | MESSENGER-RNA EXPRESSION | MYOMETRIAL CELLS | HUMAN DECIDUA | HUMAN FETAL MEMBRANES | OBSTETRICS & GYNECOLOGY | HISTOLOGIC CHORIOAMNIONITIS | INTRAUTERINE INFECTION | 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE | Interleukin-1 - genetics | Up-Regulation | Aldehyde Reductase - genetics | Toll-Like Receptor 2 - genetics | Humans | Obstetric Labor, Premature - genetics | 3-Hydroxysteroid Dehydrogenases - analysis | Prostaglandins - analysis | Calgranulin A - genetics | Intramolecular Oxidoreductases - analysis | Alcohol Oxidoreductases - genetics | Chorioamnionitis - genetics | Young Adult | Obstetric Labor, Premature - metabolism | Organic Anion Transporters - genetics | Cyclooxygenase 2 - genetics | Alcohol Oxidoreductases - analysis | Adult | Female | Multidrug Resistance-Associated Proteins - genetics | Placenta - chemistry | Prostaglandins - genetics | Cytochrome P-450 Enzyme System - analysis | Gene Expression | Multidrug Resistance-Associated Proteins - analysis | Interleukin-1 - analysis | Calgranulin A - analysis | Down-Regulation | Aldehyde Reductase - analysis | Signal Transduction - genetics | Amnion - chemistry | Gestational Age | Cyclooxygenase 2 - analysis | Hydroxyprostaglandin Dehydrogenases - genetics | Labor, Obstetric - metabolism | Organic Anion Transporters - analysis | Intramolecular Oxidoreductases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Chorion - chemistry | Prostaglandin-E Synthases | Cytochrome P-450 Enzyme System - genetics | Toll-Like Receptor 2 - analysis | Hydroxyprostaglandin Dehydrogenases - analysis | Labor, Obstetric - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Decidua - chemistry | Prostaglandins - metabolism | Studies | Placenta | Cytokines | Gene expression | Premature birth | Cesarean section | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2011, Volume 191, Issue 1, pp. 239 - 249
Aldo-keto reductases (AKRs) play central roles in the reductive metabolism of endogenous signaling molecules and in the detoxification of xenobiotics.... 
Aldo-keto reductase | Proteasome inhibitors | Colon cells | RETINOID METABOLISM | DEHYDROGENASE ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | STEROID-HORMONE | BREAST-CANCER | LUNG-CANCER | NRF2 | ALDO-KETO REDUCTASES | GENE-EXPRESSION | REVEALS ROLES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Aldehyde Reductase - genetics | Maleates - pharmacology | Humans | NF-E2-Related Factor 2 - agonists | Alcohol Oxidoreductases - biosynthesis | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Drug Interactions | Time Factors | Enzyme Induction - drug effects | Thiocyanates - pharmacology | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Isothiocyanates | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Bortezomib | RNA, Messenger - genetics | Aldehyde Reductase - biosynthesis | Alcohol Oxidoreductases - metabolism | Hydroxyprostaglandin Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | HT29 Cells | Leupeptins - pharmacology | Aldo-Keto Reductase Family 1 Member C3 | 3-Hydroxysteroid Dehydrogenases - genetics | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Phosphates | Care and treatment | Oncology, Experimental | Cytochrome P-450 | Research | Gene expression | Monosaccharides | Antioxidants | Colon cancer | Messenger RNA | Ligases | Physiological aspects | Xenobiotics | Sugars | Cancer | Index Medicus
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2016, Volume 117, Issue 4, pp. 904 - 916
Bacterial lipopolysaccharide (LPS) is the most important contributing factor in pathogenesis of bacterial infection in male accessory glands; and it has shown... 
LEYDIG CELLS | SIRT4 | STEROIDOGENESIS | APOPTOSIS | LPS | SIGNALING PATHWAYS | OXIDATIVE STRESS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | RECEPTOR | SUPPRESSION | CELL BIOLOGY | EXPRESSION | Leydig Cells - cytology | Apoptosis - drug effects | Glutathione - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Leydig Cells - drug effects | Lipopolysaccharides - antagonists & inhibitors | Stilbenes - pharmacology | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Glutathione - agonists | Leydig Cells - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Sirtuins - genetics | Cell Line | Cell Survival - drug effects | Signal Transduction | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | RNA, Messenger - genetics | Gene Expression Regulation | Rats | Glutathione - antagonists & inhibitors | Antioxidants - pharmacology | Mitochondria - drug effects | Animals | 17-Hydroxysteroid Dehydrogenases - genetics | Lipopolysaccharides - pharmacology | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Sirtuins - metabolism | Bacterial infections | RNA | Mitogens | Resveratrol | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 05/2015, Volume 156, Issue 5, pp. 1860 - 1872
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 2015, Volume 23, Issue 4, pp. 516 - 522
Hypospadias is a common male genital malformation and is regarded as a complex disease affected by multiple genetic as well as environmental factors. In a... 
INACTIVATION | ANDROGEN RECEPTOR | KLF6 | RISK-FACTORS | EXTERNAL GENITALIA | TISSUE DISTRIBUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | BIRTH-WEIGHT | DIFFERENT PHENOTYPES | UP-REGULATION | SUSCEPTIBILITY GENES | Chromosomes, Human, Pair 8 - genetics | Kruppel-Like Factor 6 | Exons | Humans | Asian Continental Ancestry Group - genetics | Male | Genotyping Techniques | Case-Control Studies | Lod Score | Microsatellite Repeats | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genetic Association Studies | Oxidoreductases - genetics | Gene Frequency | Gene Expression Regulation | Genotype | Hypospadias - genetics | Proto-Oncogene Proteins - genetics | Chromosome Mapping | Hydroxysteroid Dehydrogenases - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 10 - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Kruppel-Like Transcription Factors - genetics | Dehydrogenases | Genes | Childrens health | Families & family life | Genomes | Environmental factors | Regulatory sequences | Metabolism | Kinases | Medicine | Androgens | Hospitals | Penis | Chromosome 10 | Chromosome 8 | Boys | Genetics | Mutation | Gene mapping | Prostate cancer | Protein structure | Linkage analysis | Structure-function relationships | Index Medicus
Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2015, Volume 150, pp. 35 - 45
Dietary factors continue to preside as dominant influences in prostate cancer prevalence and progression-free survival following primary treatment. We... 
Steroidogenesis | Intratumoral androgens | Prostate cancer | CRPC | Low carbohydrate high protein diet | CANCER-CELLS | TESTOSTERONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DE-NOVO STEROIDOGENESIS | I SR-BI | SELECTIVE UPTAKE | RECEPTOR | INSULIN | CHOLESTERYL ESTER | ENDOCRINOLOGY & METABOLISM | PROGRESSION | XENOGRAFT MODEL | Dietary Proteins - administration & dosage | Neoplasm Transplantation | Receptor, IGF Type 1 - metabolism | Adenocarcinoma - pathology | Cholesterol - blood | Humans | Androgens - biosynthesis | Male | Transplantation, Heterologous | Insulin - blood | Cholesterol Esters - blood | Hydroxyprostaglandin Dehydrogenases - metabolism | Prostate - metabolism | Prostatic Neoplasms, Castration-Resistant - genetics | Prostatic Neoplasms, Castration-Resistant - pathology | Prostate - pathology | Adenocarcinoma - metabolism | Castration | Receptor, Insulin - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Prostate - drug effects | 3-Hydroxysteroid Dehydrogenases - metabolism | Adenocarcinoma - genetics | Membrane Proteins - metabolism | Diet, Western | Diet, Carbohydrate-Restricted | Prostatic Neoplasms, Castration-Resistant - diet therapy | Growth Hormone - blood | Membrane Proteins - genetics | Gene Expression Regulation | Prostatic Neoplasms, Castration-Resistant - metabolism | Receptor, IGF Type 1 - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Prostate-Specific Antigen - blood | Adenocarcinoma - diet therapy | Animals | Tumor Burden - drug effects | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Receptor, Insulin - metabolism | Mice | 3-Hydroxysteroid Dehydrogenases - genetics | Blood Glucose - metabolism | Blood sugar | Growth | Low-carbohydrate diet | Tumors | Index Medicus
Journal Article