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Biochemical Pharmacology, ISSN 0006-2952, 03/2014, Volume 88, Issue 1, pp. 36 - 45
Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) metabolises steroid hormones, prostaglandins and xenobiotics, and activates the dinitrobenzamide mustard prodrug... 
Aldo-keto reductase 1C3 | Fluorogenic assays | PR-104 | SN34037 | Leukaemia | INDUCTION | HYPOXIA | IDENTIFICATION | CANCER | A549 CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENES | AKR1C ENZYMES | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOTOXICITY | Humans | Nitrogen Mustard Compounds - pharmacokinetics | Substrate Specificity | Fluorometry - methods | Bone Marrow - enzymology | Hydroxyprostaglandin Dehydrogenases - metabolism | Leukocytes - enzymology | Prodrugs - metabolism | Urea - chemistry | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Time Factors | Enzyme Inhibitors - chemistry | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Aerobiosis | Enzyme Inhibitors - metabolism | Oxidation-Reduction | Nitrogen Mustard Compounds - pharmacology | HCT116 Cells | Heterocyclic Compounds, 4 or More Rings - chemistry | Morpholines - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Morpholines - chemistry | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Prodrugs - pharmacokinetics | Aldo-Keto Reductase Family 1 Member C3 | Nitrogen Mustard Compounds - metabolism | Heterocyclic Compounds, 4 or More Rings - metabolism | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Prodrugs - pharmacology | Drug Resistance, Neoplasm - drug effects | Leukemia | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2015, Volume 96, Issue 3, pp. 168 - 178
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 08/2013, Volume 280, Issue 16, pp. 3920 - 3927
Adiponectin is an adipocyte hormone that is predominantly secreted by adipocytes, and has important roles in glucose and lipid homeostasis. Recent studies have... 
activated protein kinase | eydig cells | adiponectin | AMP | nuclear factor‐κ | nuclear factor-κB | AMP-activated protein kinase | Leydig cells | STEROIDOGENESIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | nuclear factor-kappa B | ALPHA | ADIPOR1 | ABUNDANCE | TUMOR-NECROSIS-FACTOR | TESTIS | MICE | RECEPTORS | EXPRESSION | Up-Regulation | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Nitric Oxide Synthase Type II - chemistry | Receptors, Adiponectin - metabolism | Male | NF-kappa B - metabolism | Leydig Cells - immunology | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Receptors, Adiponectin - antagonists & inhibitors | Cyclooxygenase 2 - genetics | Leydig Cells - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | 3-Hydroxysteroid Dehydrogenases - metabolism | Adiponectin - metabolism | Cell Line | NF-kappa B - antagonists & inhibitors | Cytokines - metabolism | Signal Transduction | Cyclooxygenase 2 - chemistry | Down-Regulation | Mice, Inbred C57BL | Gene Silencing | Phosphoproteins - agonists | Phosphoproteins - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | 3-Hydroxysteroid Dehydrogenases - chemistry | Mice | Protein Processing, Post-Translational | Cytokines - antagonists & inhibitors | 3-Hydroxysteroid Dehydrogenases - genetics | Receptors, Adiponectin - genetics | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 12, pp. 8505 - 8518
Hormone-sensitive lipase (HSL) catalyzes the hydrolysis of cholesteryl esters in steroidogenic tissues and, thus, facilitates cholesterol availability for... 
B TYPE-I | SCAVENGER RECEPTOR | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOLESTEROL ESTER | TUMOR-CELLS | DIFFERENTIAL REGULATION | LIVER-X-RECEPTOR | HIGH-DENSITY-LIPOPROTEIN | MOLECULAR-MECHANISMS | MEDIATED REGULATION | RNA, Small Interfering - genetics | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Leydig Cells - enzymology | Cholesterol - blood | Sterol Esterase - metabolism | Male | Orphan Nuclear Receptors - metabolism | Phosphoproteins - metabolism | Cholesterol Esters - blood | Gene Knockdown Techniques | Cholesterol Side-Chain Cleavage Enzyme - genetics | Cyclic AMP - physiology | ATP-Binding Cassette Transporters - genetics | Leydig Cells - metabolism | Oxadiazoles - pharmacology | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Progesterone - biosynthesis | ATP Binding Cassette Transporter 1 | Cyclic AMP - metabolism | Retinoid X Receptors - metabolism | Second Messenger Systems | Sterol Regulatory Element Binding Protein 1 - metabolism | Carbamates - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Promoter Regions, Genetic | Orphan Nuclear Receptors - agonists | Cells, Cultured | Gene Expression Regulation | Scavenger Receptors, Class B - genetics | Nicotinic Acids - pharmacology | Phosphoproteins - genetics | Orphan Nuclear Receptors - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Sterol Esterase - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Retinoid X Receptors - agonists | Tetrahydronaphthalenes - pharmacology | Sterol Esterase - physiology | Bucladesine - pharmacology | Mice | Scavenger Receptors, Class B - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Perilipin-1 | Index Medicus | Testis | Signal Transduction | Molecular Cell Biology | Cell Signaling | StAR Protein | Steroidogenesis | Steroidogenic Tissues | Cyclic AMP (cAMP)
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2017, Volume 326, pp. 7 - 14
Journal Article
PLoS One, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57207 - e57207
Juvenile-onset recurrent respiratory papillomatosis (RRP) is associated with low risk human papillomavirus (HPV) types 6 and 11. Malignant transformation has... 
HEAD | RECURRENT RESPIRATORY PAPILLOMATOSIS | P16 PROTEIN | AMPLIFICATION | CELLULAR FUSION TRANSCRIPTS | MULTIDISCIPLINARY SCIENCES | HUMAN-PAPILLOMAVIRUS | TONSILLAR CARCINOMAS | CERVICAL INTRAEPITHELIAL NEOPLASIA | NECK-CANCER | HUMAN-PAPILLOMAVIRUS-16 DNA | Human papillomavirus 6 - pathogenicity | Laryngeal Neoplasms - genetics | Papilloma - genetics | Down-Regulation | Humans | Human papillomavirus 6 - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Tumor Suppressor Protein p53 - genetics | Laryngeal Neoplasms - pathology | Aldo-Keto Reductase Family 1 Member C3 | Cell Transformation, Neoplastic - genetics | Retinoblastoma Protein - genetics | Age of Onset | Fatal Outcome | Adult | Carcinoma - genetics | Female | Papilloma - pathology | 3-Hydroxysteroid Dehydrogenases - genetics | Carcinoma - pathology | Cell Transformation, Neoplastic - pathology | Immunohistochemistry | Analysis | Genes | Tumor proteins | Gene expression | Health aspects | Papillomavirus infections | Transformation | p53 Protein | INK4a protein | Otolaryngology | Fluorescence | Viruses | Genomes | Gene deletion | Cancer therapies | Carcinogenesis | Laryngeal carcinoma | Carcinogens | Human papillomavirus | Clonal deletion | Surgery | Chromosome 10 | Fluorescence in situ hybridization | Deletion | Tumorigenesis | Larynx | Neck | Lesions | Deoxyribonucleic acid--DNA | Medical research | Integration | p16 Protein | Health risks | Patients | Aldo-keto reductase | Virology | Polymerase chain reaction | Pathology | Molecular modelling | Transformations | Cervical cancer | Index Medicus | Deoxyribonucleic acid | DNA
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Journal Article
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