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3-hydroxysteroid dehydrogenases - genetics (828) 828
index medicus (821) 821
animals (483) 483
humans (451) 451
female (429) 429
3-hydroxysteroid dehydrogenases - metabolism (397) 397
male (337) 337
endocrinology & metabolism (205) 205
cholesterol side-chain cleavage enzyme - genetics (179) 179
molecular sequence data (170) 170
rna, messenger - metabolism (167) 167
biochemistry & molecular biology (155) 155
rats (146) 146
base sequence (145) 145
expression (140) 140
gene expression (133) 133
mice (124) 124
steroid 17-alpha-hydroxylase - genetics (116) 116
aldo-keto reductase family 1 member c3 (107) 107
abridged index medicus (104) 104
amino acid sequence (104) 104
hydroxyprostaglandin dehydrogenases - genetics (103) 103
phosphoproteins - genetics (102) 102
rna, messenger - genetics (99) 99
cells, cultured (98) 98
pregnancy (93) 93
reproductive biology (92) 92
reverse transcriptase polymerase chain reaction (89) 89
aromatase - genetics (81) 81
adult (80) 80
rna, messenger - analysis (76) 76
17-hydroxysteroid dehydrogenases - genetics (74) 74
steroidogenesis (74) 74
cholesterol side-chain cleavage enzyme - metabolism (73) 73
3-hydroxysteroid dehydrogenases - biosynthesis (72) 72
hydroxyprostaglandin dehydrogenases - metabolism (72) 72
progesterone (72) 72
3-beta-hydroxysteroid dehydrogenase (67) 67
testosterone (67) 67
cell biology (65) 65
mutation (65) 65
genes (64) 64
enzymes (63) 63
cloning, molecular (60) 60
gene-expression (60) 60
kinetics (60) 60
3-hydroxysteroid dehydrogenases - chemistry (59) 59
3-hydroxysteroid dehydrogenases - deficiency (59) 59
progesterone - biosynthesis (58) 58
polymerase chain reaction (57) 57
3-alpha-hydroxysteroid dehydrogenase (56) 56
phosphoproteins - metabolism (54) 54
physiological aspects (54) 54
steroids - biosynthesis (54) 54
immunohistochemistry (53) 53
middle aged (53) 53
cell line, tumor (52) 52
cells (52) 52
17-hydroxysteroid dehydrogenases - metabolism (51) 51
analysis (51) 51
gene expression regulation, enzymologic (51) 51
progesterone - metabolism (51) 51
rats, sprague-dawley (51) 51
sequence homology, amino acid (47) 47
isoenzymes - genetics (46) 46
pharmacology & pharmacy (46) 46
cattle (45) 45
cell line (45) 45
cytochrome p-450 (45) 45
steroid 17-alpha-hydroxylase - metabolism (45) 45
testis - metabolism (45) 45
blotting, northern (44) 44
toxicology (44) 44
luteinizing-hormone (43) 43
messenger-rna (43) 43
cytochrome p-450 enzyme system - genetics (42) 42
3-hydroxysteroid dehydrogenases - antagonists & inhibitors (41) 41
gene (41) 41
messenger rna (41) 41
steroidogenic enzymes (41) 41
acute regulatory protein (39) 39
blotting, western (39) 39
gene expression regulation (39) 39
gene expression regulation, enzymologic - drug effects (39) 39
child (38) 38
developmental biology (38) 38
ovary - metabolism (38) 38
aromatase - metabolism (37) 37
genetics & heredity (37) 37
leydig cells - metabolism (37) 37
liver - enzymology (36) 36
article (35) 35
recombinant proteins - metabolism (35) 35
estrogen (34) 34
hydroxysteroid dehydrogenases - genetics (34) 34
in-vitro (34) 34
oncology (34) 34
receptor (34) 34
signal transduction (34) 34
substrate specificity (34) 34
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Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
STEROIDOGENESIS | SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 535 - 548
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 4, pp. 1573 - 1584
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2013, Volume 19, Issue 20, pp. 5613 - 5625
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 35 - 44
Abiraterone suppresses intracrine androgen synthesis via inhibition of CYP17A1. However, clinical evidence suggests that androgen synthesis is not fully... 
STEROIDOGENIC ENZYME AKR1C3 | CYP17A1 INHIBITION | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | INCREASED SURVIVAL | ENZALUTAMIDE RESISTANCE | ANTITUMOR-ACTIVITY | ANDROGEN RECEPTOR GENE | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Androstenes - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Transcription, Genetic | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Cell Transformation, Neoplastic - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Animals | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasm Staging | Medical research | Transcription | Medical services | Clinical trials | Activation | Signaling | Androgens | Synthesis | Steroidogenesis | Indomethacin | Inhibition | Prostate cancer | Prostate | Cancer | Index Medicus | AKR1C3 | prostate cancer | intracrine androgens | abiraterone | indomethacin
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2011, Volume 119, Issue 1, pp. 209 - 217
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2015, Volume 24, Issue 18, pp. 5250 - 5259
Journal Article
JAMA, ISSN 0098-7484, 07/2009, Volume 302, Issue 3, pp. 261 - 275
Journal Article