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Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
STEROIDOGENESIS | SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 49, pp. 19814 - 19819
Brassinosteroids (BRs) are plant hormones that regulate growth and development. They share structural similarities with animal steroids, which are decisive... 
Phenotypes | Tassels | Inflorescences | Spikelets | Sex determination | Corn | Florets | Biosynthesis | Plants | Stamens | Uniconazole | Steroid reductase | Propiconazole | 5α-steroid reductase | 5 alpha-steroid reductase | steroid reductase | TASSEL | MULTIDISCIPLINARY SCIENCES | UNISEXUAL FLOWERS | MECHANISMS | propiconazole | FATE | uniconazole | HORMONE | GENE | BIOSYNTHESIS | GROWTH | PLANTS | ARABIDOPSIS | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - classification | Flowers - metabolism | Molecular Sequence Data | Substrate Specificity | Plant Epidermis - genetics | Phylogeny | Plant Epidermis - ultrastructure | Plant Epidermis - metabolism | In Situ Hybridization | Plant Proteins - classification | Gene Expression Regulation, Developmental | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Gene Expression Regulation, Plant | Brassinosteroids - biosynthesis | Plant Proteins - metabolism | Zea mays - metabolism | Amino Acid Sequence | Zea mays - genetics | Microscopy, Electron, Scanning | Reverse Transcriptase Polymerase Chain Reaction | Flowers - growth & development | Sequence Homology, Amino Acid | Plant Proteins - genetics | Phenotype | Plant Leaves - genetics | Plant Leaves - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Phytosterols - metabolism | Mutation | Flowers - genetics | Zea mays - growth & development | Physiological aspects | Steroid hormones | Sex determination, Genetic | Plant biology | Hormones | Plant growth | Metabolites | Index Medicus | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 07/2010, Volume 142, Issue 2, pp. 203 - 217
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Prostate cancer resistance to castration occurs because tumours acquire the metabolic capability of converting precursor steroids to 5... 
ANDROGEN RECEPTOR | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | CYP17A1 INHIBITION | MECHANISM | TESTOSTERONE | RATIONALE | MULTIDISCIPLINARY SCIENCES | INCREASED SURVIVAL | CHEMOTHERAPY | EXPOSURE | ENZALUTAMIDE | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 12/2013, Volume 154, Issue 12, pp. 4536 - 4547
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 547 - 551
Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral... 
ACTIVATION | CYP17A1 INHIBITION | RAT | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | BIOLOGY | MEN | RESISTANCE | STEROID 5-ALPHA-REDUCTASE | DIHYDROTESTOSTERONE | DEHYDROGENASE | Prostatic Neoplasms - metabolism | Dutasteride - therapeutic use | Humans | Receptors, Androgen - metabolism | Androgens - biosynthesis | Male | Androstenes - pharmacology | Abiraterone Acetate - administration & dosage | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Oxidation-Reduction - drug effects | Prostatic Neoplasms - blood | Androstenes - blood | Prostatic Neoplasms - drug therapy | Administration, Oral | Prostatic Neoplasms, Castration-Resistant - blood | Androgen Antagonists - pharmacology | 5-alpha Reductase Inhibitors - therapeutic use | Abiraterone Acetate - therapeutic use | Dutasteride - pharmacology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Androstenes - administration & dosage | Prostatic Neoplasms, Castration-Resistant - metabolism | Disease Progression | Xenograft Model Antitumor Assays | Animals | Abiraterone Acetate - blood | Abiraterone Acetate - metabolism | 5-alpha Reductase Inhibitors - pharmacology | Androgen Antagonists - therapeutic use | Androstenes - metabolism | Cell Line, Tumor | Mice | Physiological aspects | Prostate cancer | Care and treatment | Enzymes | Androgens | Metabolites | Oxidation | Metabolism | Gene expression | Steroids | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2006, Volume 103, Issue 39, pp. 14602 - 14607
Allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC) are potent positive allosteric modulators of GABA action at receptors. ALLO and THDOC are... 
Brain | Enzymes | Receptors | Messenger RNA | Neurons | Purkinje cells | Pyramidal cells | Neuroglia | Antibodies | Hippocampus | Glutamatergic neurons | 5α-reductase (type I) | GABAergic neurons | 3α-hydroxysteroid dehydrogenase | GABA(A) RECEPTOR FUNCTION | ALLOPREGNANOLONE SYNTHESIS | SOCIAL-ISOLATION | REELIN MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | STEROID 5-ALPHA-REDUCTASE | glutamatergic neurons | 3 alpha-hydroxysteroid dehydrogenase | NEUROACTIVE STEROIDS | 5 alpha-reductase (type I) | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | 3-ALPHA-HYDROXYSTEROID DIHYDRODIOL DEHYDROGENASE | Brain - enzymology | Male | Neurons - cytology | Cerebellum - enzymology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Corpus Striatum - cytology | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - genetics | Amygdala - enzymology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Hippocampus - enzymology | Corpus Striatum - enzymology | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Cerebral Cortex - enzymology | RNA, Messenger - genetics | Thalamus - enzymology | Rats | Amygdala - cytology | Hippocampus - cytology | Desoxycorticosterone - analogs & derivatives | Desoxycorticosterone - biosynthesis | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Pregnanolone - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - metabolism | Neurons - enzymology | Cerebellum - cytology | Thalamus - cytology | Mice | GABA | Research | Progesterone | Oxidoreductases | Structure | Steroids | Proteins | Rodents | Cells | Index Medicus | Biological Sciences
Journal Article