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3-phosphoinositide-dependent protein kinases (677) 677
animals (579) 579
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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 03/2003, Volume 370, Issue 2, pp. 361 - 371
Journal Article
Current Biology, ISSN 0960-9822, 04/2000, Volume 10, Issue 8, pp. 439 - 448
Background: Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are activated by phosphorylation of two... 
INSULIN | MECHANISM | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | P70(S6K) | RIBOSOMAL S6 KINASE | C-ZETA | PHOSPHOINOSITIDE 3-KINASE | HOMOLOGY | PDK1 | Insulin-Like Growth Factor I - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Ribosomal Protein S6 Kinases - metabolism | Multienzyme Complexes - metabolism | Glycogen Synthase Kinase 3 | Immunoblotting | Proto-Oncogene Proteins - chemistry | AMP-Activated Protein Kinases | Stem Cells - enzymology | Gene Deletion | Calcium-Calmodulin-Dependent Protein Kinases - pharmacology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Proto-Oncogene Proteins c-akt | Calcium-Calmodulin-Dependent Protein Kinases - chemistry | Animals | Mice | Protein-Serine-Threonine Kinases - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa | 3-phosphoinositide-dependent protein kinase 1 | ribosomal S6 kinase | Protein kinase B | MSK1 protein | AMP-activated protein kinase | AGC kinase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 52, pp. 18590 - 18595
There is great interest in developing selective protein kinase inhibitors by targeting allosteric sites, but these sites often involve protein-protein or... 
Proteins | Molecules | Phosphorylation | Prodrugs | Sulfonamides | Allosteric site | Competitive binding | Ligands | Chemicals | Crystal structure | Peptide mimicry | Allostery | Drug discovery | Protein-protein interaction | SITE | ACTIVATION | FLUORESCENCE POLARIZATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PIF-POCKET | CATALYTIC DOMAIN | MECHANISMS | IDENTIFICATION | DISCOVERY | drug discovery | PRODRUGS | peptide mimicry | protein-protein interaction | allostery | 3-Phosphoinositide-Dependent Protein Kinases - chemistry | Humans | Crystallography, X-Ray | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Allosteric Regulation - drug effects | Peptides - chemistry | Protein Structure, Secondary | 3-Phosphoinositide-Dependent Protein Kinases - genetics | Neoplasms - enzymology | Neoplasm Proteins - chemistry | 3-Phosphoinositide-Dependent Protein Kinases - antagonists & inhibitors | 3-Phosphoinositide-Dependent Protein Kinases - metabolism | Antineoplastic Agents - chemistry | Amino Acid Motifs | Neoplasms - drug therapy | Peptides - pharmacology | Allosteric Site | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Physiological aspects | Protein research | Research | Peptides | Protein kinases | Protein-protein interactions | protein–protein interaction | Biological Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 1, pp. 1 - 6
The identification of all the substrates of every protein kinase is one of the major challenges of post-genomic research. Here we review a powerful method for... 
Mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | Protein kinase B (PKB) | Glycogen synthase kinase 3 (GSK3) | Serum- and glucocorticoid-induced protein kinase (SGK) | Kinase substrate tracking and elucidation (KESTREL) | CELLS | glycogen synthase kinase 3 (GSK3) | DOMAIN | SPECIFICITY | PHOSPHORYLATION | PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM | IDENTIFICATION | IN-VITRO | protein kinase B (PKB) | kinase substrate tracking and elucidation (KESTREL) | mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | TRANSFER-RNA | STRESS | serum- and glucocorticoid-induced protein kinase (SGK) | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Reproducibility of Results | Animals | Peptide Mapping | Biochemistry - methods | Substrate Specificity | Protein Kinases - deficiency | CRMP, collapsin-response mediator protein | PI3K, phosphoinositide 3-kinase | SAKS1, SAPK-substrate 1 | TNF, tumour necrosis factor | hnRNP, heterogeneous nuclear ribonucleoprotein | PNGase, peptide N-glycanase | PDK1, 3-phosphoinositide-dependent kinase 1 | HEK, human embryonic kidney | Review | JNK, c-Jun N-terminal kinase | EF2, elongation factor 2 | UBA, ubiquitin-associated | KSHV, Kaposi sarcoma-associated herpesvirus | UBX, ubiquitin-like | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | SAPK, stress-activated protein kinase | MKK1, MAPK kinase-1 | EF2K, EF2 kinase | HSP27, heat-shock protein of 27 kDa | METTL1, methyltransferase-like protein 1 | FLNc, filamin C | NDRG, N-myc downstream-regulated gene product | VCP, valosin-containing protein | GSK3, glycogen synthase kinase 3 | SGK, serum- and glucocorticoid-induced protein kinase | IGF-1, insulin-like growth factor 1 | KESTREL, kinasesubstrate tracking and elucidation | MAPKAP-K2, MAPK-activated protein kinase-2 | CDK, cyclin-dependent protein kinase | CRHSP24, calcium-regulated heatshock protein of 24 kDa | PIC, pro-inflammatory cytokine | LPS, lipopolysaccharide | ARE, AU-rich element | CapZIP, CapZ-interacting protein | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 02/2011, Volume 34, Issue 2, pp. 224 - 236
In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt... 
SURVIVAL | EFFECTOR | L-SELECTIN | ACTIVATION | MEMORY | GLUCOSE | GENE-EXPRESSION | GENERATION | DIFFERENTIATION | IMMUNOLOGY | INTERLEUKIN-7 RECEPTOR | Pore Forming Cytotoxic Proteins - genetics | Pore Forming Cytotoxic Proteins - biosynthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Interleukin-2 - physiology | Cell Division | Receptors, Antigen, T-Cell - immunology | Transcription, Genetic | Interferon-gamma - genetics | Receptors, Cytokine - genetics | 3-Phosphoinositide-Dependent Protein Kinases | T-Lymphocytes, Cytotoxic - immunology | Adenine - analogs & derivatives | Phenylalanine - metabolism | Protein-Serine-Threonine Kinases - physiology | Receptors, Cytokine - biosynthesis | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Adenine - pharmacology | Proto-Oncogene Proteins c-akt - physiology | Animals | Class I Phosphatidylinositol 3-Kinases | T-Lymphocytes, Cytotoxic - metabolism | Glucose - metabolism | Interleukin-2 - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Mice | Quinazolines - pharmacology | Interferon-gamma - biosynthesis | Cell Movement | Cytotoxicity, Immunologic | Biotechnology | Antigens | Phosphorylation | Transcription factors | Cell division | Cytotoxicity | Kinases | Metabolism | Gene expression | Experiments | Proteins | Cell growth | Lymphocytes | Deoxyribonucleic acid--DNA
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article