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3-phosphoinositide-dependent protein kinases (509) 509
animals (446) 446
protein-serine-threonine kinases - metabolism (442) 442
humans (418) 418
phosphorylation (374) 374
index medicus (312) 312
biochemistry & molecular biology (248) 248
mice (240) 240
signal transduction (206) 206
cell biology (201) 201
activation (179) 179
protein-serine-threonine kinases - genetics (177) 177
phosphatidylinositol 3-kinases - metabolism (154) 154
pdk1 (150) 150
proto-oncogene proteins c-akt - metabolism (142) 142
proto-oncogene proteins c-akt (126) 126
enzyme activation (114) 114
male (112) 112
3-phosphoinositide-dependent protein kinase-1 (108) 108
akt (108) 108
proto-oncogene proteins - metabolism (108) 108
apoptosis (103) 103
cell line (103) 103
proteins (96) 96
phosphatidylinositol 3-kinase (95) 95
protein-serine-threonine kinases - antagonists & inhibitors (93) 93
cell line, tumor (92) 92
3-phosphoinositide-dependent protein kinases - metabolism (91) 91
cells, cultured (90) 90
signal transduction - drug effects (90) 90
in-vivo (89) 89
animal structures (87) 87
cancer (87) 87
female (85) 85
rats (85) 85
amino acid sequence (84) 84
molecular sequence data (84) 84
oncology (83) 83
pathway (79) 79
protein kinases (79) 79
article (77) 77
phosphorylation - drug effects (74) 74
kinases (73) 73
mutation (73) 73
expression (67) 67
phosphoinositide 3-kinase (64) 64
protein-serine-threonine kinases - physiology (64) 64
research (63) 63
protein kinase c - metabolism (60) 60
protein-serine-threonine kinases - chemistry (60) 60
signal transduction - physiology (60) 60
enzyme inhibitors - pharmacology (59) 59
insulin (58) 58
protein-kinase (58) 58
research article (58) 58
transfection (58) 58
binding sites (56) 56
growth (55) 55
cells (53) 53
protein kinase inhibitors - pharmacology (52) 52
signal-transduction (51) 51
cell proliferation (50) 50
mice, knockout (50) 50
enzyme activation - drug effects (49) 49
physiological aspects (48) 48
3-phosphoinositide-dependent protein kinases - genetics (47) 47
phosphatidylinositol 3-kinases - antagonists & inhibitors (47) 47
gene expression (46) 46
insulin - pharmacology (46) 46
protein binding (46) 46
protein kinases - metabolism (45) 45
identification (44) 44
protein structure, tertiary (44) 44
biophysics (43) 43
multidisciplinary sciences (43) 43
physiology (43) 43
apoptosis - drug effects (41) 41
time factors (41) 41
signaling pathway (40) 40
mice, inbred c57bl (39) 39
blotting, western (38) 38
inhibition (38) 38
survival (38) 38
isoenzymes - metabolism (37) 37
protein-kinase-b (37) 37
ribosomal protein s6 kinases - metabolism (37) 37
analysis (36) 36
models, biological (36) 36
insulin - metabolism (35) 35
binding (34) 34
cell survival (34) 34
gene-expression (34) 34
endocrinology & metabolism (33) 33
cell proliferation - drug effects (32) 32
domain (32) 32
immunology (32) 32
proto-oncogene proteins c-akt - genetics (32) 32
tor serine-threonine kinases (32) 32
tyrosine phosphorylation (32) 32
biochemistry (31) 31
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Journal Article
Cancer Research, ISSN 0008-5472, 08/2009, Volume 69, Issue 15, pp. 6299 - 6306
Journal Article
Neoplasia, ISSN 1476-5586, 2012, Volume 14, Issue 8, pp. 719 - IN19
Journal Article
Journal Article
CURRENT BIOLOGY, ISSN 0960-9822, 04/2000, Volume 10, Issue 8, pp. 439 - 448
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal Article
Current Biology, ISSN 0960-9822, 04/2000, Volume 10, Issue 8, pp. 439 - 448
Background: Protein kinase B (PKB), and the p70 and p90 ribosomal S6 kinases (p70 S6 kinase and p90 Rsk, respectively), are activated by phosphorylation of two... 
3-phosphoinositide-dependent protein kinase 1 | ribosomal S6 kinase | Protein kinase B | MSK1 protein | AMP-activated protein kinase | AGC kinase
Journal Article
European Journal of Immunology, ISSN 0014-2980, 05/2015, Volume 45, Issue 5, pp. 1548 - 1559
Journal Article