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Journal Article
Journal Article
Journal Article
Cell, ISSN 0092-8674, 09/2019, Volume 178, Issue 6, pp. 1437 - 1451.e14
CCCTC-binding factor (CTCF) and cohesin are key players in three-dimensional chromatin organization. The topologically associating domains (TADs) demarcated by... 
cohesin | SINE B2 transposable element | ChAHP | chromatin looping | Hi-C | CHD4 | ADNP | CTCF | 3D chromatin architecture | Helsmoortel-van-der-Aa syndrome | Medicine, Experimental | Medical research | Chromatin | Transposons | Wildlife conservation | Genomics | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 09/2018, Volume 175, Issue 1, pp. 224 - 238.e15
More than 25 inherited human disorders are caused by the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). A fundamental... 
trinucleotide repeat expansion disorders | subTADs | genome instability | short tandem repeats | fragile X syndrome | 3D genome folding | TADs | topologically associating domains | higher-order chromatin architecture | LINEAGE COMMITMENT | CTG REPEAT | HUMAN GENOME | DNA METHYLATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRAGILE-X-SYNDROME | CTCF | HUNTINGTONS-DISEASE | TRINUCLEOTIDE REPEATS | MYOTONIC-DYSTROPHY | CELL BIOLOGY | Humans | CCCTC-Binding Factor - genetics | Trinucleotide Repeat Expansion - physiology | Chromatin Assembly and Disassembly - genetics | Fragile X Mental Retardation Protein - physiology | Male | Fragile X Mental Retardation Protein - metabolism | CCCTC-Binding Factor - physiology | Disease - etiology | Chromatin - physiology | Adult | Female | Fragile X Syndrome - genetics | Cell Line | Brain - cytology | Disease - genetics | Fragile X Syndrome - metabolism | Microsatellite Repeats - physiology | CpG Islands - physiology | Genome, Human - genetics | Microsatellite Repeats - genetics | DNA - genetics | Brain - pathology | CpG Islands - genetics | Trinucleotide Repeat Expansion - genetics | Fragile X Mental Retardation Protein - genetics | Chromatin - genetics | Chromatin Assembly and Disassembly - physiology | Epigenetic inheritance | Medical colleges | Anopheles | Chromatin | Genomics | Plants | Nucleotide sequencing | DNA sequencing | Index Medicus
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 1 - 14
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly... 
TRANSCRIPTION FACTORS | ORGANIZATION | ORCHESTRATE | 3D GENOME | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | COHESIN | DOMAINS | MAMMALIAN GENOMES | CHROMATIN ARCHITECTURE | REVEALS | Regulators | Chromatin | Transcription | Gene regulation | Embryo cells | Genomes | Topology | Gene expression | Domains | Enhancers | Landscapes | Stem cells | Occupancy | Cohesin | Configurations | Binding sites | Pluripotency | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 09/2018, Volume 174, Issue 6, pp. 1522 - 1536.e22
How transcription affects genome 3D organization is not well understood. We found that during influenza A (IAV) infection, rampant transcription rapidly... 
transcription elongation | cohesin | transcription | transcription termination | genome 3D structure | CTCF | readthrough transcription | chromatin compaction | NS1 | influenza A virus | PHASE-SEPARATION | NS1 PROTEIN | INFLUENZA-A VIRUS | CIS-REGULATORY ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | LOOP EXTRUSION | PRE-MESSENGER-RNAS | POLYMERASE-II | CHROMATIN ARCHITECTURE | MAMMALIAN GENOMES | CELL BIOLOGY | Chromatin - metabolism | Transcription, Genetic - drug effects | Humans | CCCTC-Binding Factor - metabolism | CCCTC-Binding Factor - chemistry | RNA Polymerase II - metabolism | Macrophages - virology | Piperidines - pharmacology | RNA Interference | Flavonoids - pharmacology | Influenza A Virus, H5N1 Subtype - metabolism | Nuclear Proteins - genetics | Binding Sites | Chromatin - chemistry | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Viral Nonstructural Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Macrophages - cytology | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Interferon-beta - pharmacology | Nuclear Proteins - antagonists & inhibitors | Protein Binding | RNA Polymerase II - genetics | Viral Nonstructural Proteins - metabolism | Genome, Human | RNA, Small Interfering - metabolism | Medical colleges | Chromatin | RNA | Microbiology | Genes | Genomics | Communicable diseases | Genomes | Genetic transcription | Anopheles | Influenza | Genetic aspects | Health aspects | Index Medicus | read-through transcription
Journal Article
IMMUNITY, ISSN 1074-7613, 08/2013, Volume 39, Issue 2, pp. 229 - 244
The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates V-H-DJ(H) recombination by juxtaposing distal... 
IMMUNOGLOBULIN LOCI | GENOMIC INTERACTIONS | 3D STRUCTURE | V(D)J RECOMBINATION | HEAVY-CHAIN LOCUS | PRO-B CELLS | IMMUNOLOGY | INTRONIC ENHANCER | REGULATORY ELEMENTS | CHROMATIN ARCHITECTURE | SWITCH RECOMBINATION
Journal Article