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4-arylcoumarin analogs (33) 33
biological evaluation (26) 26
chemistry, organic (22) 22
derivatives (13) 13
chemistry, medicinal (11) 11
coumarins (11) 11
index medicus (11) 11
antineoplastic agents (10) 10
chemistry, multidisciplinary (10) 10
humans (10) 10
antineoplastic agents - pharmacology (9) 9
cross-coupling reactions (9) 9
structure-activity relationship (8) 8
tubulin (8) 8
colchicine (7) 7
combretastatin a-4 analogs (7) 7
4-arylcoumarin (6) 6
4-phenylcoumarins (6) 6
anticancer agents (6) 6
antineoplastic agents - chemical synthesis (6) 6
arylboronic acids (6) 6
coumarin (6) 6
cross-coupling (6) 6
synthesis (6) 6
analysis (5) 5
antineoplastic agents - chemistry (5) 5
binding (5) 5
cancer (5) 5
catalysis (5) 5
combretastatins (5) 5
drug screening assays, antitumor (5) 5
inhibitors (5) 5
natural-products (5) 5
organic chemistry (5) 5
pharmacy (5) 5
tubulins (5) 5
4-substituted coumarins (4) 4
animals (4) 4
apoptosis (4) 4
apoptosis - drug effects (4) 4
biochemistry & molecular biology (4) 4
cell line, tumor (4) 4
cell proliferation - drug effects (4) 4
cells (4) 4
colchicine site (4) 4
coumarins - chemical synthesis (4) 4
coumarins - chemistry (4) 4
coumarins - pharmacology (4) 4
cytotoxicity (4) 4
intramolecular nicholas reactions (4) 4
antiinflammatory activity (3) 3
antimitotic agents (3) 3
antitumor agents (3) 3
arylation (3) 3
chemistry (3) 3
colchicine - pharmacology (3) 3
common pharmacophore (3) 3
diels-alder reactions (3) 3
efficient (3) 3
efficient synthesis (3) 3
in-vitro (3) 3
in-vivo (3) 3
letter (3) 3
models, molecular (3) 3
molecular structure (3) 3
palladium (3) 3
polymerization (3) 3
suzuki-miyaura (3) 3
tubulin - metabolism (3) 3
2h-1-benzopyran-2-one (2) 2
2h-chromen-2-one (2) 2
[ sdv ] life sciences [q-bio] (2) 2
[sdv]life sciences [q-bio] (2) 2
acetates (2) 2
acylation (2) 2
allocolchicinoids (2) 2
anti-cancer (2) 2
anticancer (2) 2
antiproliferative activity (2) 2
antitumor activity (2) 2
antitumor-activity (2) 2
aryl bond formation (2) 2
binding sites (2) 2
bond formation (2) 2
chemotherapy (2) 2
click chemistry (2) 2
colchicine - analogs & derivatives (2) 2
colchicine - chemical synthesis (2) 2
colchicine - chemistry (2) 2
colon-cancer cells (2) 2
dose-response relationship, drug (2) 2
drug design (2) 2
drug resistance (2) 2
embryos (2) 2
furans - chemical synthesis (2) 2
furans - chemistry (2) 2
furans - pharmacology (2) 2
heterocycles (2) 2
heterocyclic compounds (2) 2
indoles - chemical synthesis (2) 2
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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 20, pp. 5290 - 5302
Journal Article
Synlett, ISSN 0936-5214, 05/2012, Volume 2012, Issue 8, pp. 1205 - 1208
Abstract A series of novel combretastatin A-4 analogues was synthesized in 36–64% yields by Negishi cross-coupling reaction under mild conditions. The prepared... 
letter | cross-coupling | magnesium-zinc exchange | organometallic reagents | cytotoxicity | antitumor agents | ANTICANCER AGENTS | NATURAL-PRODUCTS | VASCULAR-DISRUPTING AGENTS | ANTINEOPLASTIC AGENTS | ANTIMITOTIC AGENT | CHEMISTRY, ORGANIC | COMBRETUM-CAFFRUM | RAMBERG-BACKLUND REACTION | 4-ARYLCOUMARIN ANALOGS | TUBULIN | BINDING
Journal Article
Journal Article
Chemical Communications, ISSN 1359-7345, 03/2012, Volume 48, Issue 24, pp. 2985 - 2987
A straightforward and atom-economical base-free palladium-catalyzed regioselective direct arylation of coumarins and chromenones is devised. This protocol is... 
COMBRETASTATINS | 4-PHENYLCOUMARINS | DIRECT ARYLATION | REAGENTS | BASE-FREE | BIOLOGICAL EVALUATION | 4-ARYLCOUMARIN ANALOGS | ALKENYL | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | ARYLBORONIC ACIDS | Coumarins - chemistry | Catalysis | Flavones - chemistry | Oxidation-Reduction | Palladium - chemistry
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2016, Volume 57, Issue 41, pp. 4629 - 4632
A convenient and efficient approach for the synthesis of 4-indolyl coumarins and 4-indolyl quinolinones was developed via palladium-catalyzed coupling... 
4-Indolyl coumarins | 4-Indolyl quinolinones | Antiproliferative activity | Coupling reaction | COMBRETASTATINS | 4-PHENYLCOUMARINS | CHEMISTRY, ORGANIC | ALKYNOATES | IN-VITRO | NEOFLAVONOIDS | BIOLOGICAL EVALUATION | 4-HYDROXYCOUMARIN | 4-ARYLCOUMARIN ANALOGS | DERIVATIVES | CYCLIZATION | Coumarins | Palladium
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 126, pp. 432 - 443
Journal Article
Synlett, ISSN 0936-5214, 09/2013, Volume 24, Issue 14, pp. 1772 - 1776
Abstract A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19–84% yields. Five of the... 
letter | isocombretastatins | turbo Grignard reagent | antitubulin agents | Negishi cross-coupling | cytotoxicity | HALIDES | MICROTUBULE | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | SUZUKI-MIYAURA | COMBRETASTATIN A-4 ANALOGS | BIOLOGICAL EVALUATION | CHEMISTRY | 4-ARYLCOUMARIN ANALOGS | TUBULIN | 1,1-DIARYLETHYLENES
Journal Article
Synlett, ISSN 0936-5214, 11/2017, Volume 28, Issue 18, pp. 2499 - 2504
Abstract A novel ammonium iodide-induced sulfenylation of 4-hydroxycoumarins or 4-hydroxyquinolinones by using an aryl- or alkylsulfonyl chloride as the sulfur... 
letter | sulfanylhydroxyquinolinones | sulfenylation | sulfonyl chlorides | ammonium iodide | C-S bond formation | sulfanylhydroxycoumarins | CHEMISTRY, ORGANIC | BOND FORMATION | SELECTIVE FLUORESCENT CHEMOSENSOR | ARYLSULFONYL CHLORIDES | IN-VIVO | 4-ARYLCOUMARIN ANALOGS | METAL | HIV-1 REVERSE-TRANSCRIPTASE | INHIBITORS | DERIVATIVES | WATER
Journal Article
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