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Bioorganic Chemistry, ISSN 0045-2068, 04/2018, Volume 77, pp. 600 - 607
Indoleamine 2,3-dioxygenase is a heme-containing enzyme implicated in the down regulation of the anti-tumor immune response, and considered a promising... 
Anti-tumor | Tryptophan | Kynurenine | Indoleamine 2,3-dioxygenase | Inhibitor | In vivo target inhibition | 4-Bromophenylhydrazinyl benzenesulfonylphenylurea | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | benzenesulfonylphenylurea | PROLIFERATION | 4-Bromophenylhydrazinyl | T-CELL | SUPPRESSION | DRAINING LYMPH-NODES | TRYPTOPHAN CATABOLISM | PLASMACYTOID DENDRITIC CELLS | LUNG-CANCER | IDO | EXPRESSION | DERIVATIVES | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Sulfones - pharmacology | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | CD3 Complex - isolation & purification | Sulfones - chemistry | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Sulfones - chemical synthesis | Biomarkers, Tumor - analysis | Enzyme Inhibitors - pharmacology | Rats | Antineoplastic Agents - chemistry | Biomarkers, Tumor - isolation & purification | Rats, Sprague-Dawley | CD3 Complex - analysis | Animals | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Neoplasms, Experimental - drug therapy | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Drug Screening Assays, Antitumor | T cells | Pharmaceutical industry | Tumors
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