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1. Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells
by Lei, L and Tzekov, R and Tang, S and Kaushal, S
Molecular Vision, ISSN 1090-0535, 01/2012, Volume 18, pp. 103 - 113
Purpose: To explore the ability of macrophages and microglial cells to phagocytize rod outer segments (ROSs) in a cell culture and characterize the resulting... 
4-Hydroxynonenal
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2. The Connection of Monocytes and Reactive Oxygen Species in Pain. e63564
by Hackel, Dagmar and Pfluecke, Diana and Neumann, Annick and Viebahn, Johannes and Mousa, Shaaban and Wischmeyer, Erhard and Roewer, Norbert and Brack, Alexander and Rittner, Heike Lydia
PLoS ONE, 05/2013, Volume 8, Issue 5
The interplay of specific leukocyte subpopulations, resident cells and proalgesic mediators results in pain in inflammation. Proalgesic mediators like reactive... 
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3. 4-Hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis
by Bruckner, SR and Perry, G and Estus, S
Journal of Neurochemistry, ISSN 0022-3042, 05/2003, Volume 85, Issue 4, pp. 999 - 1005
Reactive oxygen species are a necessary triggering event for apoptosis of sympathetic neurons after nerve growth factor (NGF) withdrawal. Reactive oxygen... 
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4. Lipid peroxidation in the postnatal rat brain: Formation of 4-hydroxynonenal in the supraventricular corpus callosum of postnatal rats
by Cao, Q and Ong, WY and Halliwell, B
Experimental Brain Research, ISSN 0014-4819, 03/2001, Volume 137, Issue 2, pp. 205 - 213
Lipid peroxidation is known to be associated with many neurodegenerative diseases and with traumatic brain injury, but its occurrence in the normal developing... 
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5. 4-Hydroxynonenal-modified amyloid- beta peptide inhibits the proteasome: possible importance in Alzheimer's disease
by Shringarpure, R and Grune, T and Sitte, N and Davies, KJA
Cellular and Molecular Life Sciences, ISSN 1420-682X, 11/2000, Volume 57, Issue 12, pp. 1802 - 1809
The amyloid beta -peptide (A beta ) is a 4-kDa species derived from the amyloid precursor protein, which accumulates in the brains of patients with Alzheimer's... 
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6. 4-Hydroxynonenal, a Lipid Peroxidation Byproduct of Spinal Cord Injury, Is Cytotoxic for Oligodendrocyte Progenitors and Inhibits Their Responsiveness to PDGF
by Gard, AL and Solodushko, VG and Waeg, G and Majic, T
Microscopy Research and Technique, ISSN 1059-910X, 03/2001, Volume 52, Issue 6, pp. 709 - 718
Oligodendroglial reactions to compression injury of spinal cord include apoptosis, secondary demyelination, and remyelination failure. Within hours after... 
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7. Origin of 4-hydroxynonenal incubation-induced inhibition of dopamine transporter and Na super(+)/K super(+) adenosine triphosphate in rat striatal synaptosomes
by Fleuranceau-Morel, P and Barrier, L and Fauconneau, B and Piriou, A and Huguet, F
Neuroscience Letters, ISSN 0304-3940, 12/1999, Volume 277, Issue 2, pp. 91 - 94
Previous experiments reported that an incubation of striatal synaptosomes with 4-hydroxynonenal (4-HNE) resulted in an inhibition of dopamine (DA) uptake and... 
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8. Full Text Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors
by Negre‐Salvayre, A and Coatrieux, C and Ingueneau, C and Salvayre, R
British Journal of Pharmacology, ISSN 0007-1188, 01/2008, Volume 153, Issue 1, pp. 6 - 20
Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar glycoxidation, namely Advanced lipid peroxidation end products (ALEs) and... 
atherosclerosis | neurodegenerative diseases | inflammation | carbonyl scavenger | ALE | cancer | carbonyl stress | diabetes | lipid peroxidation | 4‐hydroxynonenal | Carbonyl scavenger | Neurodegenerative diseases | Atherosclerosis | Carbonyl stress | Lipid peroxidation | Inflammation | Diabetes | 4-hydroxynonenal | Cancer | KAPPA-B ACTIVATION | LINKED-IMMUNOSORBENT-ASSAY | LENS EPITHELIAL-CELLS | N-TERMINAL KINASE | LOW-DENSITY-LIPOPROTEIN | IN-VITRO FORMATION | lipid | 4-HYDROXYNONENAL MODIFIED PROTEINS | VASCULAR SMOOTH-MUSCLE | peroxidation | ADVANCED GLYCATION ENDPRODUCTS | AMYLOID-BETA-PEPTIDE | PHARMACOLOGY & PHARMACY | Cardiovascular Diseases - etiology | Aldehydes - toxicity | Neoplasms - etiology | Oxidation-Reduction | Signal Transduction | Neurodegenerative Diseases - etiology | Humans | NF-kappa B - metabolism | Antioxidants - pharmacology | Inflammation - etiology | Animals | Proteins - metabolism | Lipoproteins, LDL - metabolism | Cell Cycle - drug effects | Lipid Peroxidation | Aging - metabolism | Neurodegenerative Diseases | Cardiovascular Diseases | Biochemistry, Molecular Biology | Aldehydes | Neoplasms | Proteins | Antioxidants | Life Sciences | NF-kappa B | Cell Cycle | Aging | Lipoproteins, LDL | Reviews
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9. Full Text Diff erential oxidative modifi cation of proteins in MRL +/+ and MRL/lpr mice: Increased formation of lipid peroxidation-derived aldehyde-protein adducts may contribute to accelerated onset of autoimmune response
by Wang, Gangduo and Li, Hui and Firoze Khan, M
Free Radical Research, ISSN 1071-5762, 12/2012, Volume 46, Issue 12, pp. 1472 - 1481
protein adducts | malondialdehyde | autoantibodies | lipid peroxidation | 4-hydroxynonenal
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10. Full Text Phospholipase A 2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
by Muralikrishna Adibhatla, Rao and Hatcher, J.F
Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 40, Issue 3, pp. 376 - 387
Ischemic stroke is caused by obstruction of blood flow to the brain, resulting in energy failure that initiates a complex series of metabolic events,... 
Oxidative stress | Stroke | Free radicals | CNS injury | Phosphatidylcholine | Cytidine-5′-diphosphocholine | Arachidonic acid | 4-hydroxynonenal
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11. Full Text PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress
by Salabei, Joshua K and Cummins, Timothy D and Singh, Mahavir and Jones, Steven P and Bhatnagar, Aruni and Hill, Bradford G
Biochemical Journal, ISSN 0264-6021, 05/2013, Volume 451, Issue 3, pp. 375 - 388
Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth muscle cells) to increased concentrations of growth factors. The... 
Restenosis | 4-hydroxy-nonenal (4-HNE) | Spautin | Autophagy | Atherosclerosis | Growth factor | atherosclerosis | ALPHA-ACTIN | 4-hydroxynonenal (4-HNE) | restenosis | autophagy | ATHEROSCLEROTIC PLAQUES | LIPID-PEROXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOLATED RAT HEPATOCYTES | growth factor | spautin | GROWTH-FACTOR RECEPTOR | INTIMAL HYPERPLASIA | PROTECTIVE ROLE | SERUM RESPONSE FACTOR | OXIDIZED PHOSPHOLIPIDS | DIFFERENTIATION MARKERS | Osteopontin - genetics | Microtubule-Associated Proteins - genetics | Muscle, Smooth, Vascular - metabolism | Oxidative Stress | Microtubule-Associated Proteins - metabolism | Vimentin - metabolism | Actins - metabolism | Male | Osteopontin - metabolism | Aorta - metabolism | Autophagy - drug effects | Actins - genetics | Vimentin - genetics | Aldehydes - pharmacology | Macrolides - pharmacology | Microfilament Proteins - metabolism | Autophagy - genetics | Myocytes, Smooth Muscle - drug effects | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | Adenine - analogs & derivatives | Aorta - drug effects | Rats | Adenine - pharmacology | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Phenotype | Animals | Signal Transduction - drug effects | Aorta - cytology | Primary Cell Culture | Calcium-Binding Proteins - genetics | 4-hydroxynonenal
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12. Full Text Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function1
by Mark A. Baker and Anita Weinberg and Louise Hetherington and Ana-Izabel Villaverde and Tony Velkov and Jonathan Baell and Christopher P. Gordon
Biology of Reproduction, ISSN 0006-3363, 2015, Volume 92, Issue 4
ABSTRACT Lipid peroxidation products such as the naturally occurring aldehyde 4-hydroxynonenal (4-HNE) are known to be cytotoxic toward different cell types,... 
methyltransferase | proteomics | epigenetics | protein kinase | 4-hydroxynonenal
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13. Full Text Relation between TLR4/NF‐κB signaling pathway activation by 27‐hydroxycholesterol and 4‐hydroxynonenal, and atherosclerotic plaque instability
by Gargiulo, Simona and Gamba, Paola and Testa, Gabriella and Rossin, Daniela and Biasi, Fiorella and Poli, Giuseppe and Leonarduzzi, Gabriella
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 569 - 581
Summary It is now thought that atherosclerosis, although due to increased plasma lipids, is mainly the consequence of a complicated inflammatory process, with... 
atherosclerosis | cytokines | 27‐hydroxycholesterol | MMP‐9 | TLR4 | 4‐hydroxynonenal | 27-Hydroxycholesterol | 4-Hydroxynonenal | Cytokines | MMP-9 | Atherosclerosis | Tumor Necrosis Factor-alpha - metabolism | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Plaque, Atherosclerotic - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Monocytes - metabolism | NF-kappa B - metabolism | Interleukin-1beta - genetics | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Aldehydes - pharmacology | Monocytes - pathology | Interleukin-8 - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Plaque, Atherosclerotic - pathology | Cell Line | Plaque, Atherosclerotic - metabolism | Signal Transduction | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | Hydroxycholesterols - pharmacology | Toll-Like Receptor 4 - metabolism | Monocytes - drug effects | NF-kappa B - genetics | Models, Biological | RNA, Small Interfering - metabolism | 27-hydroxycholesterol | Original | 4-hydroxynonenal
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14. Full Text TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress
by Trevisan, Gabriela and Benemei, Silvia and Materazzi, Serena and De Logu, Francesco and De Siena, Gaetano and Fusi, Camilla and Fortes Rossato, Mateus and Coppi, Elisabetta and Marone, Ilaria Maddalena and Ferreira, Juliano and Geppetti, Pierangelo and Nassini, Romina
Brain, ISSN 0006-8950, 05/2016, Volume 139, Issue 5, pp. 1361 - 1377
The mechanisms underlying trigeminal neuropathic pain (TNP) are unknown. Using the infraorbital nerve constriction mouse model, Trevisan et al. show that nerve... 
CCL2 | CION | NADPH oxidase | hydrogen peroxide | 4-hydroxynonenal | COLD HYPERALGESIA | DIFFERENTIAL-DIAGNOSIS | NEUROGENIC INFLAMMATION | WALLERIAN DEGENERATION | DIRECT ACTIVATION | NEUROSCIENCES | CLINICAL NEUROLOGY | SCIATIC-NERVE | CHRONIC CONSTRICTION INJURY | QUANTITATIVE ASSESSMENT | ION-CHANNEL | NERVE LIGATION | Transient Receptor Potential Channels - antagonists & inhibitors | Clodronic Acid - pharmacology | Neuralgia - metabolism | Male | Monocytes - metabolism | Acetophenones - pharmacology | Purines - antagonists & inhibitors | Transient Receptor Potential Channels - physiology | Neuralgia - physiopathology | Oximes - antagonists & inhibitors | Acetanilides - pharmacology | Hyperalgesia - metabolism | Purines - pharmacology | Thioctic Acid - pharmacology | Hyperalgesia - physiopathology | Mice, Knockout | Monocytes - drug effects | Macrophages - metabolism | Animals | Acetanilides - antagonists & inhibitors | Transient Receptor Potential Channels - genetics | TRPA1 Cation Channel | Oximes - pharmacology | Macrophages - drug effects | Mice | Oxidative Stress - drug effects | Chemokine CCL2 - antagonists & inhibitors
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15. Full Text A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis
by Cao, Shengchuan and Bian, Yuan and Zhou, Xin and Yuan, Qiuhuan and Wei, Shujian and Xue, Li and Yang, Feihong and Qianqian Dong and Wenjun Wang and Zheng, Boyuan and Zhang, Jian and Wang, Zheng and Han, Ziqi and Yang, Kehui and Rui, Haiying and Zhang, Ying and Xu, Feng and Chen, Yuguo
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019
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16. Full Text Redox proteomics identification of 4-hydroxynonenalmodified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis
by Perluigi, Marzia and Sultana, Rukhsana and Cenini, Giovanna and Di Domenico, Fabio and Memo, Maurizio and Pierce, William M and Coccia, Raffaella and Butterfield, D. Allan
Proteomics - Clinical Applications, ISSN 1862-8346, 2009, Volume 3, Issue 6, pp. 682 - 693
Lipid peroxidation | Redox proteomics | Protein oxidation | 4-Hydroxynonenal | Alzheimer's disease
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17. Full Text Lipid peroxidation is involved in calcium dependent upregulation of mitochondrial metabolism in skeletal muscle
by Al-Menhali, Afnan Saleh and Banu, Sameem and Angelova, Plamena R and Barcaru, Andrei and Horvatovich, Peter and Abramov, Andrey Y and Jaganjac, Morana
BBA - General Subjects, ISSN 0304-4165, 03/2020, Volume 1864, Issue 3, p. 129487
Background: Skeletal muscle cells continuously generate reactive oxygen species (ROS). Excessive ROS can affect lipids resulting in lipid peroxidation (LPO).... 
Lipid peroxidation | Mitochondrial metabolism | Reactive oxygen species | Calcium oscillations | NADH | 4-hydroxynonenal
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