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Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2016, Volume 28, Issue 5, pp. 412 - 424
Iron is an indispensable micronutrient that regulates many aspects of cell function, including growth and proliferation. These processes are critically... 
Rheb | TSC2 | 4E-BP1 | PP2A | Akt | S6K1 | Deferoxamine | ACTIVATION | ACID | HYPOXIA | PROTEIN-SYNTHESIS | DEFICIENCY | CELL BIOLOGY | MTORC1 | DEPENDENT REGULATION | MESSENGER-RNA | GROWTH | EXPRESSION | Caco-2 Cells | Deferoxamine - pharmacology | Intestinal Mucosa - metabolism | Protein Biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | TOR Serine-Threonine Kinases - metabolism | Down-Regulation | Humans | Transcription Factors - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - metabolism | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Iron Chelating Agents - pharmacology | Signal Transduction - drug effects | Intestinal Mucosa - enzymology | Iron - deficiency | Protein Phosphatase 2 - metabolism | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proteins | Protein biosynthesis | Phosphatases | Protein binding | Index Medicus | Reduction | Phosphorylation | Depletion | Protein synthesis | Mathematical models | Iron | Signalling | S6K1, ribosomal protein S6 kinase 1 | PP2A, protein phosphatase 2A | 4E-BP1, eIF4E-binding protein 1 | DMT-1, divalent metal transporter-1 | TfR, transferrin receptor | HIF, hypoxia-inducible factor | S6, ribosomal protein S6 | DFO, deferoxamine | PI3K, phosphatidylinositol 3-kinase | mTOR, mammalian target of rapamycin | REDD1, regulated in DNA damage and development 1 | IRS, insulin receptor substrate
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 18, pp. 2924 - 2929
Target of rapamycin complex 1 (TORC1) has a key role in cellular regulations in response to environmental conditions. In yeast, Tip41 downregulates TORC1... 
mTOR | PP2A | Amino acid | mTORC1 | TIPRL | eIF4E-binding protein 1 | hemagglutinin | small interfering RNA | TORC | Tap42 | Tap42-interacting protein of 41 kDa | p70 ribosomal protein S6 kinase 1 | protein phosphatase 2A | tumor necrosis factor-related apoptosis-inducing ligand | hepatocellular carcinoma | TRAIL | mechanistic TOR | target of rapamycin signaling pathway regulator-like | HCC | Tip41 | siRNA | TOR complex | PP2A catalytic subunit | S6K1 | type 2A phosphatase-associated protein of 42 kDa | TOR | PP2Ac | 4E-BP1 | target of rapamycin | PHOSPHATASE 2A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | IDENTIFICATION | P70 S6 KINASE | EIF-4E BP1 | CELL BIOLOGY | YEAST | BIOPHYSICS | TOR SIGNALING PATHWAY | 2A CATALYTIC SUBUNIT | TAP42 | Cell Line | RNA, Small Interfering - genetics | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Gene Expression Regulation | Protein Phosphatase 2 - genetics | Rats | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Point Mutation | Animals | TOR Serine-Threonine Kinases - genetics | Transfection | Protein Phosphatase 2 - metabolism | Mice | Intracellular Signaling Peptides and Proteins - genetics | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 06/2014, Volume 588, Issue 14, pp. 2246 - 2254
The balance between the rates of protein synthesis and degradation in muscle is regulated by PI3K/Akt signaling. Here we addressed the effect of ERK activation... 
Mechanistic target of rapamycin | Sodium tungstate | LC3 | Extracellular signal-regulated kinases 1 and 2 | Forkhead box O Family of Transcription Factors | Skeletal muscle | ubiquitin C | sodium tungstate | eIF4E-binding protein 1 | IGF-I | tuberous sclerosis factor 2 | mechanistic target of rapamycin | Insulin Growth Factor I | eukaryotic initiation factor E | PI3K | protein kinase B | dexamethasone | FoxO | eIF4E | PKB/Akt | extracellular signal-regulated kinases 1 and 2 | TSC2 | MTOR | S6K1 | MEK | DEX | UbC | 4E-BP1 | mitogen-activated protein kinase kinase | phosphatidyl-inositol-3-kinase | ribosomal S6 kinase 1 | ERK | PATHWAYS | SKELETAL-MUSCLE ATROPHY | GLYCOGEN-SYNTHESIS | MECHANISM | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Factors | AUTOPHAGY | FOXO TRANSCRIPTION FACTORS | Forkhead box O Family of Transcription | CELL BIOLOGY | INSULIN | BIOPHYSICS | GENE-EXPRESSION | TUBEROUS SCLEROSIS | Transcription, Genetic - drug effects | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Ubiquitin - metabolism | Tungsten Compounds - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | MAP Kinase Signaling System | Heat-Shock Proteins - genetics | Proteolysis - drug effects | Dexamethasone - pharmacology | Forkhead Transcription Factors - metabolism | Muscular Atrophy - prevention & control | Drug Evaluation, Preclinical | Heat-Shock Proteins - metabolism | Rats | Ubiquitin - genetics | Animals | Glucocorticoids - pharmacology | Protein Biosynthesis - drug effects | Enzyme Activation | Proteasome Endopeptidase Complex - metabolism | Forkhead Box Protein O3 | Muscles | Protein biosynthesis | Dexamethasone | Proteolysis | Tungsten compounds | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2005, Volume 388, Issue 3, pp. 973 - 984
The hypertrophic G(q)-protein-coupled receptor agonist PE (phenylephrine) activates protein synthesis. We showed previously that activation of protein... 
mTOR | Mnk | Protein synthesis | Extracellular-signal-regulated kinase (ERK) | Hypertrophy | Myocyte | MESSENGER-RNA TRANSLATION | ADULT-RAT CARDIOMYOCYTES | hypertrophy | myocyte | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY | protein synthesis | INITIATION-FACTOR 4E | EPIDIDYMAL FAT-CELLS | P70 S6 KINASE | extracellular-signal-regulated kinase (ERK) | CARDIAC-HYPERTROPHY | DUAL-SPECIFICITY PHOSPHATASES | DISTINCT SIGNALING PATHWAYS | Cell Line | Insulin - pharmacology | Tumor Suppressor Proteins - metabolism | Aniline Compounds - pharmacology | Signal Transduction | Purines - pharmacology | Humans | Rats | Male | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Sirolimus - pharmacology | Gene Expression Regulation - drug effects | Myocytes, Cardiac - enzymology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Myocytes, Cardiac - drug effects | Phenylephrine - pharmacology | Myocytes, Cardiac - metabolism | Protein Biosynthesis - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | MEK, MAPK | p90RSK, 90 kDa ribosomal protein S6 kinase | PI3K, phosphoinositide 3-kinase | TSC, tuberous sclerosis complex | MKP3, MAPK phosphatase 3 | JNK, c-Jun N-terminal kinase | ERK kinase | ERK, extracellular-signal-regulated kinase | Mnk, MAPK-interacting kinase | PKB, protein kinase B | GSK, glycogen synthase kinase | PE, phenylephrine | mTOR, mammalian target of rapamycin | eIF, eukaryotic initiation factor | S6K, ribosomal protein S6 kinase | GFP, green fluorescent protein | HEK-293 cells, human embryonic kidney 293 cells | ARVC, adult rat ventricular cardiomyocytes | 4E-BP1, eIF4E-binding protein 1 | IEF, isoelectric focusing | MOI, multiplicity of infection | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2006, Volume 397, Issue 1, pp. 187 - 194
In response to different cellular stresses, a family of protein kinases phosphorylates eIF2alpha (alpha subunit of eukaryotic initiation factor-2),... 
Pilocarpine | Temporal lobe epilepsy model | α subunit of eukaryotic initiation factor-2 (eIF2α) | Double-stranded-RNA-dependent protein kinase (PKR) | Status epilepticus | Translation initiation | Phosphorylation | Protein Biosynthesis | eIF-2 Kinase - metabolism | Mice, Inbred C57BL | Cerebral Cortex - pathology | Miotics | Epilepsy, Temporal Lobe - physiopathology | Hippocampus - pathology | Cerebral Cortex - metabolism | Brain - metabolism | Hippocampus - metabolism | Animals | Cell Death | Mice | Status Epilepticus - metabolism | Index Medicus | ATF4, activating transcription factor 4 | dsRNA, double-stranded RNA | eIF2α, α subunit of eukaryotic initiation factor-2 | HRI, haem-regulated eIF2α kinase | translation initiation | TLE, temporal lobe epilepsy | temporal lobe epilepsy model | eIF2α(P), phosphorylated eIF2α | PERK, pancreatic eIF2α kinase | HRP, horseradish peroxidase | PP1, protein phosphatase 1 | double-stranded-RNA-dependent protein kinase (PKR) | RPL32, ribosomal protein L32 | RNA-dependent-protein-kinase-like ER kinase | 4E-BP1, eIF4E-binding protein 1 | SE, status epilepticus | pilocarpine | status epilepticus | PKR, dsRNA-dependent protein kinase | PACT, PKR-activating protein | PEK | GADD34, growth-arrest and DNA-damage-inducible protein 34 | ER, endoplasmic reticulum | IRES, internal ribosomal entry site | ISR, integrated stress response
Journal Article