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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2013, Volume 21, Issue 6, pp. 1451 - 1464
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2018, Volume 26, Issue 16, pp. 4624 - 4634
A family of dipeptidyl enoates has been prepared and tested against the parasitic cysteine proteases rhodesain, cruzain and falcipain-2 related to sleeping... 
Cysteine proteases | Chagas disease | Inhibitors | Sleeping sickness | Malaria | CHEMISTRY, MEDICINAL | TRYPANOSOMA-BRUCEI | RHODESAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHODESIENSE | CHEMISTRY, ORGANIC | NITRILES | DRUGS | Index Medicus
Journal Article
Neurology, ISSN 0028-3878, 11/2013, Volume 81, Issue 22, pp. 1945 - 1952
OBJECTIVES:To validate the ability of candidate CSF biomarkers to distinguish between the 2 main forms of frontotemporal lobar degeneration (FTLD), FTLD with... 
Ab42 5 b-amyloid 1-42 | FTD 5 frontotemporal degeneration | FTLD 5 frontotemporal lobar degeneration | FTLD-TDP 5 frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43) inclusions | P-Tau181 5 Tau phosphorylated at threonine 181 | Penn 5 University of Pennsylvania | PN 5 peripheral neuropathy | AUC 5 area under the curve | ALS 5 amyotrophic lateral sclerosis | ROC 5 receiver operating characteristic | T-Tau 5 total Tau | FTLD-Tau 5 frontotemporal lobar degeneration with Tau inclusions | CI 5 confidence interval | AD 5 Alzheimer disease | IL 5 interleukin | PSP 5 progressive supranuclear palsy | Frontotemporal Lobar Degeneration - cerebrospinal fluid | Phosphorylation | Peptide Fragments - cerebrospinal fluid | Humans | Intercellular Signaling Peptides and Proteins - genetics | Male | tau Proteins - cerebrospinal fluid | Chi-Square Distribution | DNA-Binding Proteins - genetics | Threonine - metabolism | Proteins - genetics | DNA-Binding Proteins - cerebrospinal fluid | Interleukin-23 - cerebrospinal fluid | Frontotemporal Lobar Degeneration - diagnosis | Sensitivity and Specificity | Amyloid beta-Peptides - cerebrospinal fluid | Female | C9orf72 Protein | Biomarkers - cerebrospinal fluid | Frontotemporal Lobar Degeneration - genetics | Cohort Studies | Index Medicus | Abridged Index Medicus | 111 | 166 | 178
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2011, Volume 585, Issue 20, pp. 3259 - 3262
Journal Article
1973, Report (Chemical Control Research Institute (Canada)), Volume CC-X-39., iii, 56
5
Book
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2012, Volume 20, Issue 15, pp. 4635 - 4645
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2014, Volume 588, Issue 18, pp. 3469 - 3474
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3′,5′-cyclic monophosphate (cNMP)... 
HPLC–MS | Cyclic CMP | Cyclic nucleotides | Enzyme kinetics | Second messenger | Phosphodiesterase | cNMP | human lung carcinoma cell line | A549 | high performance liquid chromatography tandem mass spectrometry | adenosine 3′,5′-cyclic monophosphate | glutathione-S-transferase protein tag | inosine 5′-monophosphate | nucleoside 3′,5′-cyclic monophosphate | uridine 3′,5′-cyclic monophosphate | rat neuroblastoma cells | cXMP | insect cell line | cTMP | guanosine 5′-monophosphate | hyperpolarization-activated cyclic nucleotide-gated cation channel | uridine 5′-monophosphate | human embryonic kidney cell line | AMP | guanosine 3′,5′-cyclic monophosphate | U-937 | CMP | PKA | Sf9 | adenylyl cyclase toxin | Bordetella pertussis | GMP | IMP | PKG | HuT 78 | HCN | HPLC–MS/MS | CyaA | thymidine 3′,5′-cyclic monophosphate | UMP | hexahistidine tag | cIMP | cGMP | cAMP | cCMP | inosine 3′,5′-cyclic monophosphate | cytidine 5′-monophosphate | PDE | human promonocytic cell line | xanthosine 3′,5′-cyclic monophosphate | xanthosine 5′-monophosphate | human lymphoblast cell line | HEK-293 | protein kinase G | cUMP | protein kinase A | P. aeruginosa | multidrug resistance-associated protein 5 | exotoxin Y | Spodoptera frugiperda | GST | thymidine 5′-monophosphate | B103 | MRP5 | HIS | adenosine 5′-monophosphate | TMP | cytidine 3′,5′-cyclic monophosphate | XMP | phosphodiesterase | ExoY | HPLCMS | MAMMALIAN-TISSUES | CELLS | SPECIFICITY | PURINE | HPLC-MS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLASE ACTIVITY | CELL BIOLOGY | BIOPHYSICS | CYCLIC CMP PHOSPHODIESTERASE | SUBSTRATE | PYRIMIDINE | LIVER | NUCLEOTIDE PHOSPHODIESTERASES | Cyclic CMP - chemistry | Sulfonamides - chemistry | Humans | Nitro Compounds - chemistry | Substrate Specificity | Cyclic Nucleotide Phosphodiesterases, Type 7 - chemistry | Spodoptera | Hydrolysis | Sf9 Cells | Animals | Cyclic AMP - chemistry | Cell Line, Tumor | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Kinetics | Phosphodiesterase Inhibitors - chemistry | Second Messenger Systems | Index Medicus
Journal Article
Neurology, ISSN 0028-3878, 12/2017, Volume 89, Issue 24, pp. 2406 - 2412
OBJECTIVE:The purpose of this study of sickle cell disease (SCD) was to determine whether arteriopathy, measurable as intracranial vessel signal loss on... 
STROKE | OBSTRUCTIVE SLEEP-APNEA | BLOOD-FLOW-VELOCITY | RISK-FACTOR | HEMOGLOBIN OXYGEN-SATURATION | TRANSCRANIAL DOPPLER ULTRASONOGRAPHY | ANEMIA | CLINICAL NEUROLOGY | MAGNETIC-RESONANCE ANGIOGRAPHY | CEREBROVASCULAR-DISEASE | CHILDREN | Index Medicus | Abridged Index Medicus | 150 | 293
Journal Article
Journal Article