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1. Full Text New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sites
by Lee, Inhan and Ajay, Subramanian S and Jong, In Yook and Hyun, Sil Kim and Su, Hyung Hong and Nam, Hee Kim and Dhanasekaran, Saravana M and Chinnaiyan, Arul M and Athey, Brian D
Genome Research, ISSN 1088-9051, 07/2009, Volume 19, Issue 7, pp. 1175 - 1183
MicroRNAs (miRNAs) are known to post-transcriptionally regulate target mRNAs through the 3'-UTR, which interacts mainly with the 5'-end of miRNA in animals.... 
POSTTRANSCRIPTIONAL REGULATION | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | LET-7 | TRANSLATION | MESSENGER-RNA DEGRADATION | IMPACT | REPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | MIRNAS | MAMMALS | Wnt1 Protein - genetics | Kidney - embryology | Cytoskeletal Proteins - genetics | Humans | RNA, Messenger - genetics | 3' Untranslated Regions - genetics | Molecular Sequence Data | 3' Untranslated Regions - metabolism | Wnt1 Protein - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Blotting, Western | Transfection | Base Sequence | RNA, Messenger - antagonists & inhibitors | Axin Protein | Cytoskeletal Proteins - metabolism | MicroRNAs - genetics | Cell Culture Techniques | 5' Untranslated Regions - physiology | Messenger RNA | Research | Genetic transcription | Human genome | Analysis | Letter
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2. Full Text Target mRNAs Are Repressed as Efficiently by microRNA-Binding Sites in the 5' UTR as in the 3' UTR
by J. Robin Lytle and Therese A. Yario and Joan A. Steitz
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 23, pp. 9667 - 9672
In animals, microRNAs (miRNAs) bind to the 3' UTRs of their target mRNAs and interfere with translation, although the exact mechanism of inhibition of protein... 
Untranslated regions | Messenger RNA | Transfection | MicroRNA | RNA | Plasmids | DNA | Ribosomes | HeLa cells | Repression | Translation efficiency | Internal ribosome entry sites | Method of transfection | Let-7 miRNP | ENTRY SITE | INITIATION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | translation efficiency | PROTEIN-SYNTHESIS | MAMMALIAN-CELLS | MEDIATED TRANSLATIONAL REPRESSION | internal ribosome entry sites | let-7 miRNP | REGULATORY RNA | CAENORHABDITIS-ELEGANS | repression | method of transfection | HEPATITIS-C | MOLECULAR-MECHANISMS | Luciferases - metabolism | Humans | Gene Expression Regulation | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | MicroRNAs - metabolism | 5' Untranslated Regions - metabolism | Ribonucleoproteins - metabolism | Transcription Factors - genetics | Luciferases - genetics | Transcription Factors - metabolism | Animals | Base Sequence | Argonaute Proteins | Eukaryotic Initiation Factor-2 - metabolism | Protein Biosynthesis - genetics | HeLa Cells | Caenorhabditis elegans Proteins - genetics | Repression (Psychology) | Research | Genetic translation | Biological Sciences
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3. Full Text Contributions of 5′-UTR and 3′-UTR cis elements to Cyt1Aa synthesis in Bacillus thuringiensis subsp. israelensis
by Sakano, Yuko and Park, Hyun-Woo and Bideshi, Dennis K and Ge, Baoxue and Federici, Brian A
Journal of Invertebrate Pathology, ISSN 0022-2011, 10/2017, Volume 149, pp. 66 - 75
The biopesticide used most effectively to control mosquito and blackfly vectors of human diseases worldwide is subsp. . The high efficacy of this bacterium is... 
3′-UTR | 5′-UTR | Transcriptional terminator | cyt1Aa | Promoters | Bacillus thuringiensis subsp. israelensis | CRYSTAL PROTEIN GENE | ESCHERICHIA-COLI | RECOMBINANT BACTERIA | 20-KILODALTON PROTEIN | MOSQUITOCIDAL ACTIVITY | Bacillus thuringiensis subsp israelensis | MESSENGER-RNA SEQUENCE | ZOOLOGY | 5'-UTR | DELTA-ENDOTOXIN GENE | 3'-UTR | MOLECULAR-CLONING | TRANSCRIPTIONAL REGULATION | NUCLEOTIDE-SEQUENCE | Promoter Regions, Genetic | 5' Untranslated Regions | Bacillus thuringiensis - genetics | Endotoxins - genetics | Hemolysin Proteins - genetics | Bacterial Proteins - genetics | 3' Untranslated Regions | Proteins | Analysis | transcriptional terminator | 3’-UTR | promoters | 5’-UTR
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4. Full Text 5′-UTR RNA G-quadruplexes: Translation regulation and targeting
by Bugaut, Anthony and Balasubramanian, Shankar
Nucleic Acids Research, ISSN 0305-1048, 06/2012, Volume 40, Issue 11, pp. 4727 - 4741
RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional regulation of gene expression. Much of the knowledge in this area... 
STABLE G-QUADRUPLEX | HUMAN TELOMERIC RNA | REPEAT-CONTAINING RNA | SMALL-MOLECULE | G-QUARTET | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRAGILE-X-SYNDROME | GENE-EXPRESSION | SECONDARY STRUCTURE | EXPANDED SEQUENCE D(CGG)(N) | PREMUTATION MESSENGER-RNA | Protein Biosynthesis | G-Quadruplexes - drug effects | 5' Untranslated Regions | RNA-Binding Proteins - metabolism | Gene Expression Regulation | Post-transcription | Translation | Reviews | DNA | Computer applications | Double-stranded RNA | nucleic acids | Gene expression | Survey and Summary
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5. Full Text A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis
by Miyamoto, Yoshinari and Mabuchi, Akihiko and Shi, Dongquan and Kubo, Toshikazu and Takatori, Yoshio and Saito, Susumu and Fujioka, Mikihiro and Sudo, Akihiro and Uchida, Atsumasa and Yamamoto, Seizo and Ozaki, Koichi and Takigawa, Masaharu and Tanaka, Toshihiro and Nakamura, Yusuke and Jiang, Qing and Ikegawa, Shiro
Nature Genetics, ISSN 1061-4036, 04/2007, Volume 39, Issue 4, pp. 529 - 533
Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging... 
SEQUENCE POLYMORPHISMS | GENE | HIP OSTEOARTHRITIS | MUTATION | GENETICS & HEREDITY | CHONDROSARCOMA CELL-LINE | ACID REPEAT POLYMORPHISM | MORPHOGENETIC PROTEINS | KNEE-OSTEOARTHRITIS | CHONDROGENESIS | CHONDRODYSPLASIA | Genetic Predisposition to Disease | Bone Morphogenetic Proteins - physiology | Gene Frequency | Humans | Asian Continental Ancestry Group - genetics | Cells, Cultured | Gene Expression Regulation | Polymorphism, Single Nucleotide - physiology | Case-Control Studies | Osteoarthritis - genetics | Linkage Disequilibrium | Growth Differentiation Factor 5 | Transfection | 5' Untranslated Regions | Bone Morphogenetic Proteins - genetics | Research | Diagnosis | Health aspects | Osteoarthritis | Genetic polymorphisms | Risk factors | Arthritis | Gene expression | Orthopedics | Genes | Polymorphism | Asians
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6. Full Text 5 ' UTR m(6)A Promotes Cap-Independent Translation
by Meyer, KD and Patil, DP and Zhou, J and Zinoviev, A and Skabkin, MA and Elemento, O and Pestova, TV and Qian, SB and Jaffrey, SR
CELL, ISSN 0092-8674, 11/2015, Volume 163, Issue 4, pp. 999 - 1010
Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some... 
EIF3 | INTERNAL RIBOSOME ENTRY | ACTIVATION | MESSENGER-RNA METHYLATION | MECHANISM | INITIATION-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITES | REGULATORS | NUCLEOTIDE-RESOLUTION | STRESS | CELL BIOLOGY | Protein Biosynthesis | Humans | Eukaryotic Initiation Factor-4E - metabolism | Ribosomes - metabolism | Eukaryotic Initiation Factor-3 - metabolism | HSP72 Heat-Shock Proteins - metabolism | Peptide Chain Initiation, Translational | Embryo, Mammalian - metabolism | Animals | 5' Untranslated Regions | Adenosine - analogs & derivatives | Adenosine - metabolism | Mice | HeLa Cells | Fibroblasts - metabolism
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7. Full Text RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation
by Xue, Shifeng and Xue, Shifeng and Tian, Siqi and Fujii, Kotaro and Kladwang, Wipapat and Das, Rhiju and Barna, Maria
Nature, ISSN 0028-0836, 01/2015, Volume 517, Issue 7532, pp. 33 - 38
Emerging evidence suggests that the ribosome has a regulatory function in directing how the genome is translated in time and space. However, how this... 
MESSENGER-RNAS | AXIAL SKELETON | ROBUST ANALYSIS | ENTRY SITE | CAP-DEPENDENT TRANSLATION | SPECIALIZED RIBOSOMES | MULTIDISCIPLINARY SCIENCES | LINKED DYSKERATOSIS-CONGENITA | CAPILLARY-ELECTROPHORESIS | MEDIATED TRANSLATION | SECONDARY STRUCTURE | Cell Line | Gene Expression Regulation - genetics | Ribosomes - chemistry | Molecular Sequence Data | Ribosomes - metabolism | Substrate Specificity | 5' Untranslated Regions - genetics | Genes, Homeobox - genetics | RNA Caps - metabolism | Zebrafish - genetics | Ribosomal Proteins - metabolism | Animals | Bone and Bones - metabolism | Conserved Sequence | Mice | Protein Biosynthesis - genetics | Bone and Bones - embryology | Regulatory Sequences, Ribonucleic Acid - genetics | Evolution, Molecular | RNA sequencing | Physiological aspects | Usage | Genetic regulation | Identification and classification | Ribosomes | Proteins | Genomes | Mammals | Gene expression | Ribonucleic acid--RNA
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8. An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
by Kumari, Sunita and Bugaut, Anthony and Huppert, Julian L and Balasubramanian, Shankar
Nature Chemical Biology, ISSN 1552-4450, 2007, Volume 3, Issue 4, pp. 218 - 221
Guanine-rich nucleic acid sequences can adopt noncanonical four-stranded secondary structures called guanine (G)- quadruplexes(1). Bioinformatics analysis... 
GENE | RAS | HAIRPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Gene Expression | Protein Biosynthesis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Molecular Sequence Data | 5' Untranslated Regions - genetics | Proto-Oncogene Proteins p21(ras) - biosynthesis | DNA - genetics | Guanine - metabolism | Animals | Plasmids | Base Sequence | G-Quadruplexes | Guanine - chemistry | Hypotheses | Ribonucleic acid | Genetics | Biochemistry | Gene expression | Ribonucleic acid--RNA | Bioinformatics | Cancer
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9. Full Text Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
by Lai, Eric C
Nature Genetics, ISSN 1061-4036, 04/2002, Volume 30, Issue 4, pp. 363 - 364
Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is... 
ENCODES | POSTTRANSCRIPTIONAL REGULATION | CAENORHABDITIS-ELEGANS | PROTEIN | LIN-14 | GENETICS & HEREDITY | ENHANCER | C-ELEGANS | BOX | Nucleic Acid Hybridization | Caenorhabditis elegans - genetics | Molecular Sequence Data | RNA, Untranslated - genetics | Amino Acid Motifs | Sequence Homology, Amino Acid | Animals | 5' Untranslated Regions | Base Sequence | MicroRNAs | RNA, Antisense - chemistry | RNA, Untranslated - chemistry | 3' Untranslated Regions | Drosophila - genetics | RNA, Antisense - genetics | Physiological aspects | Research | Genetic transcription | RNA | Genetic regulation
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10. Full Text NanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
by Gandin, Valentina and Masvidal, Laia and Hulea, Laura and Gravel, Simon-Pierre and Cargnello, Marie and McLaughlan, Shannon and Cai, Yutian and Balanathan, Preetika and Morita, Masahiro and Rajakumar, Arjuna and Furic, Luc and Pollak, Michael and Porco, John A and St-Pierre, Julie and Pelletier, Jerry and Larsson, Ola and Topisirovic, Ivan
Genome Research, ISSN 1088-9051, 05/2016, Volume 26, Issue 5, pp. 636 - 648
The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation... 
MAMMALIAN TRANSLATION | EIF4A | MITOCHONDRIAL ACTIVITY | NONCODING REGION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS | 4E-BP1 PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MCF-7 Cells | TOR Serine-Threonine Kinases - metabolism | Humans | Protein Biosynthesis - physiology | Eukaryotic Initiation Factor-4E - metabolism | Female | Apoptosis - physiology | 5' Untranslated Regions - physiology | Toll-like receptors | Messenger RNA | Research | Genetic translation
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11. Full Text Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
by Leppek, Kathrin and Das, Rhiju and Barna, Maria
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 03/2018, Volume 19, Issue 3, pp. 158 - 174
RNA molecules can fold into intricate shapes that can provide an additional layer of control of gene expression beyond that of their sequence. In this Review,... 
C-MYC-IRES | INTERNAL RIBOSOME ENTRY | OPEN READING FRAME | TRANS-ACTING FACTORS | GENOME-WIDE ANALYSIS | IRES-MEDIATED TRANSLATION | SECONDARY STRUCTURE | G-QUADRUPLEX | TRACT-BINDING-PROTEIN | CAP-INDEPENDENT TRANSLATION | CELL BIOLOGY | Eukaryotes | Messenger RNA | Genetic aspects | Research | Genetic transcription | Properties | Genetic translation | DNA helicase | Post-transcription | Translation | Ribonucleic acids | Mutagenesis | 5' Untranslated Regions | Translation initiation | Gene expression | RNA helicase
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