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Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2018, Volume 17, Issue 9, pp. 1833 - 1845
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 beta-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis,... 
ANDROGEN RECEPTOR | ACTIVATION | METABOLISM | ONCOLOGY | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | TESTOSTERONE | RESISTANCE | PHASE-II | F SYNTHASE | CANCER | ADRENAL ANDROGENS | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 936 - 946
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2014, Volume 278, Issue 3, pp. 238 - 248
Pharmacokinetic drug resistance is a serious obstacle that emerges during cancer chemotherapy. In this study, we investigated the possible role of aldo-keto... 
Anthracyclines | Aldo-keto reductase 1C3 | Drug resistance | Metabolism | Enzyme induction | DOXORUBICIN | TUMOR-CELLS | INDUCTION | STEROID-HORMONE | DAUNORUBICIN | ENDOMETRIAL CANCER | BREAST-CANCER | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MCF-7 CELLS | Antibiotics, Antineoplastic - pharmacology | Humans | Daunorubicin - agonists | Daunorubicin - pharmacology | Idarubicin - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Anthracyclines - agonists | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Anthracyclines - pharmacology | Biotransformation | Anthracyclines - metabolism | Enzyme Induction - drug effects | 3-Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Neoplasm Proteins - genetics | Antibiotics, Antineoplastic - agonists | Carcinoma - drug therapy | Idarubicin - metabolism | Recombinant Proteins - metabolism | Cell Survival - drug effects | Oxidation-Reduction | Flavanones - pharmacology | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Drug Synergism | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Antibiotics, Antineoplastic - metabolism | Idarubicin - agonists | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Physiological aspects | Chemotherapy | Cancer cells | Cancer | Index Medicus | CARBONYLS | METABOLISM | NEOPLASMS | ENZYMES | DRUGS | TOXICITY | INCUBATION | 60 APPLIED LIFE SCIENCES | ENZYME INDUCTION | CHEMOTHERAPY
Journal Article
Journal Article