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Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2018, Volume 18, Issue 13, pp. 1919 - 1926
The potential of steroids for development into lead pharmacological molecules lies in the regulation of a variety of biological processes by these molecules... 
5α-reductase inhibition | Benzylidines | Phenylhydrazones | Pyrazoline | Pregnenolone
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 01/2016, Volume 63, pp. 59 - 67
Neurosteroids exert diverse modulatory actions on dopamine neurotransmission and signaling. We previously documented that the enzyme 5α-reductase, which... 
Dopamine | Finasteride | Prepulse inhibition of the startle | 5α-Reductase | Neurosteroids
Journal Article
10/2011
Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms (LUTS). A better understanding of... 
treatment | α1-adrenergic antagonist | Benign prostatic hyperplasia | 5α-reductase inhibitors | prostate
Web Resource
Psychoneuroendocrinology, ISSN 0306-4530, 10/2019, Volume 108, pp. 53 - 61
The extraction of salient information from the environment is modulated by the activation of dopamine receptors. Using rodent models, we previously reported... 
Sensorimotor gating | Behavioral studies | 5α-reductase | Dopamine | D1receptors | Allopregnanolone | Index Medicus
Journal Article
NMR in biomedicine, ISSN 0952-3480, 5/2017, Volume 30, Issue 5
The study purpose was to determine whether 5α-reductase inhibitors (5-ARIs) affect the discrimination between low-grade prostate cancer (PCa) and benign... 
dutasteride | prostate cancer | 5α-reductase inhibitors | mpMRI | finasteride
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 11/2019, Volume 194, pp. 105433 - 105433
The steroid hormones not only exert various endocrine functions but also act as the autocrine or paracrine factors in different tissues of mammals. In the... 
Estrogen receptor | Epididymis | Dihydrotestosterone | Androgen receptor | Muskrat | 5α-reductase | P450arom | Index Medicus
Journal Article
Acta Medica Mediterranea, ISSN 0393-6384, 2019, Volume 35, Issue 2, pp. 739 - 744
Journal Article
Psychiatry Research, ISSN 0165-1781, 10/2019, Volume 280, pp. 112503 - 112503
Anxiety and depressive disorders are more prevalent in hypogonadal men. Low testosterone levels are associated with greater negative symptoms and impaired... 
Testosterone | Polyglutamine | Androgen receptor | CAG | Post-mortem | Sex steroid hormones | 5α-reductase | Gene expression | Index Medicus
Journal Article
General and comparative endocrinology, 08/2019, pp. 113245 - 113245
Dihydrotestosterone (DHT) and 17β-estradiol (E2) are sex hormones that regulate human hair follicle (HF) growth and are produced by peripheral reduction and... 
Index Medicus
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 05/2019, Volume 67, pp. 44 - 50
Global fructose consumption is on the rise; however, maternal high-fructose intake may have adverse effects on offspring. We previously demonstrated that... 
5α-Reductase 1 | Adrenal | Corticosterone | 11β-Hydroxysteroid dehydrogenase type 2 | Fructose
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2007, Volume 120, Issue 2, pp. 285 - 291
Previous in vitro studies demonstrated that bioactive androgen 5α‐dihydrotestosterone (DHT) exerted antiproliferative effects through an interaction with... 
breast cancer | androgen | androgen receptor | 5α‐reductase | aromatase | 5α-reductase | Breast cancer | Androgen | Aromatase | Androgen receptor
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 2019, p. jmedgenet-2018-105915
The 5α-reductase type 2 (5α-RD2) deficiency caused by mutations in the steroid 5α-reductase 2 ( ) gene results in variable degrees of undervirilisation in... 
steroid 5α-reductase 2 gene | 5α-reductase type 2 deficiency | distribution | founder effect | genotype-phenotype correlation
Journal Article
Expert Opinion on Drug Safety, ISSN 1474-0338, 10/2019, Volume 18, Issue 10, pp. 915 - 923
Introduction: Muscarinic receptor antagonists, 5α-reductase inhibitors and α 1 -adrenoceptor antagonists are frequently used drug classes for the treatment of... 
α | 1 | adrenoceptor antagonists | muscarinic receptor antagonists | 5α-reductase inhibitors | cognitive impairment | depression | Index Medicus
Journal Article
Translational Stroke Research, ISSN 1868-4483, 02/2019, Volume 10, Issue 1, pp. 67 - 77
Progesterone (P4) exerts potent neuroprotection both in young and aged animal models of stroke. The neuroprotection is likely to be mediated by... 
Stroke | Finasteride | Progesterone | 5α-reductase inhibitor | Middle cerebral artery occlusion | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2014, Volume 231, Issue 17, pp. 3609 - 3618
Preclinical studies support the hypothesis that endogenous neuroactive steroids mediate some effects of alcohol.The aim of this study was to examine the effect... 
Human subjects | Neurosciences | Biomedicine | 5α-Reductase | Neuroactive steroids | Pharmacology/Toxicology | Psychiatry
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2019, Volume 190, pp. 263 - 272
Androgens are steroid hormones essential for human male and female development. Steroid reductases 5α (SRD5As) are key enzymes in androgen biosynthesis.... 
Steroidogenesis | SRD5A2 | Bioinformatics | 5α-reductase(s) | Androgen excess | Androgen deficiency | Polycystic ovary syndrome | Phenotypes | Transcription | Single-nucleotide polymorphism | Testosterone | Androgens | Enzymatic activity | Metabolites | Post-translation | Mutation | Progesterone | Enzyme kinetics | Androstenedione | Prostate cancer | Steroid hormones | Reductase
Journal Article
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