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British Journal of Pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1252 - 1262
Background and Purpose The 5‐HT3 receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy... 
cancer therapy | irreversible antagonism | down‐regulation | receptor trafficking | emesis | endocytosis | 5‐HT3 receptor | palonosetron | allosterism | receptor | down-regulation | 5-HT | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | PROTEIN-KINASE-C | CHEMOTHERAPY-INDUCED NAUSEA | HUMAN PLASMA | PHASE-III | ONDANSETRON | IN-VITRO | MODERATELY EMETOGENIC CHEMOTHERAPY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | EXPRESSION | 5-HT3 receptor | Receptors, Serotonin, 5-HT3 - chemistry | Allosteric Regulation | Humans | Serotonin 5-HT3 Receptor Antagonists - metabolism | Cercopithecus aethiops | Protein Transport - drug effects | Isoquinolines - pharmacology | Nystatin - pharmacology | Cell Membrane - metabolism | Radioligand Assay | Granisetron - pharmacology | Cell Membrane - drug effects | Isoquinolines - metabolism | Recombinant Proteins - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Endocytosis - drug effects | Quinuclidines - pharmacology | Recombinant Proteins - chemistry | Down-Regulation - drug effects | Hydrazones - pharmacology | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Granisetron - metabolism | Kinetics | Serotonin 5-HT3 Receptor Antagonists - pharmacology | COS Cells | Quinuclidines - metabolism | Antiemetics - pharmacology | Health aspects | Nausea | Enzyme-linked immunosorbent assay | Binding sites | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 736 - 747
The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit results in heteromeric 5‐HT3AB receptors that are functionally distinct... 
5‐HT3A | 5‐HT3B | allosteric | 5‐HT3 | 5‐HT3AB | ion channel | Cys‐loop | ligand gated | antagonist | ligand | 5-HT3AB | 5-HT | 5-HT3A | Cys-loop | 5-HT3B | GATED ION-CHANNEL | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | SEROTONIN 5-HT3 | CYS-LOOP RECEPTORS | MOLECULAR DETERMINANTS | NEUROBLASTOMA-CELLS | STRUCTURAL DETERMINANTS | 5-HT3 | 5-HTAB RECEPTORS | GABA(A) RECEPTOR | PHARMACOLOGY & PHARMACY | LIGAND-BINDING SITE | Receptors, Serotonin, 5-HT3 - chemistry | Humans | Molecular Conformation | Protein Multimerization | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Antiemetics - therapeutic use | Antiemetics - chemistry | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites - drug effects | Protein Subunits - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Models, Molecular | Recombinant Proteins - chemistry | Binding, Competitive - drug effects | Serotonin 5-HT3 Receptor Antagonists - therapeutic use | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Ligands | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Agonists - therapeutic use | Antiemetics - pharmacology | Competition | Reviews
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1228 - 1238
Background and Purpose The 5‐HT3 receptor is a ligand‐gated ion channel that is modulated allosterically by various compounds including colchicine, alcohols... 
ligand‐gated ion channel | 5‐HT3 receptor | allosteric modulation | receptor | 5-HT | ligand-gated ion channel | SINGLE-CHANNEL CONDUCTANCE | IDENTIFICATION | SEROTONIN-RECEPTOR | ARRIVE GUIDELINES | N1E-115 NEUROBLASTOMA-CELLS | IN-VIVO | PHARMACOLOGY & PHARMACY | 5-HYDROXYINDOLE | EXPRESSION | 5-HT3 receptor | SUBUNIT | AGONIST | Receptors, Serotonin, 5-HT3 - chemistry | Allosteric Regulation | Humans | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Male | Receptors, Serotonin - genetics | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Indoles - metabolism | HEK293 Cells | Indoles - pharmacology | Serotonin 5-HT3 Receptor Antagonists - chemistry | Protein Subunits - genetics | Recombinant Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Nerve Tissue Proteins - agonists | Protein Subunits - agonists | Recombinant Proteins - chemistry | Receptors, Serotonin - chemistry | Nerve Tissue Proteins - genetics | Receptors, Serotonin - metabolism | Evoked Potentials - drug effects | Nerve Tissue Proteins - metabolism | Animals | Calcium Signaling - drug effects | Muscle Contraction - drug effects | Receptors, Serotonin, 5-HT3 - metabolism | Urinary Bladder - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Analysis | Colchicine | Research Papers
Journal Article
Journal Article
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 05/2008, Volume 20, Issue 5, pp. 557 - 565
In this study, we examined the effects of serotonin (5‐HT)3 receptor antagonists (5‐HT3RAs) including ramosetron, alosetron, and cilansetron on colonic... 
colonic nociceptive threshold | 5‐HT3 receptor antagonist | diarrhoea | colonic hyperalgesia | irritable bowel syndrome | restraint stress | Colonic hyperalgesia | Restraint stress | Colonic nociceptive threshold | Irritable bowel syndrome | Diarrhoea | 5-HT | receptor antagonist | RAMOSETRON | ALOSETRON | NEUROSCIENCES | CLINICAL NEUROLOGY | THERAPEUTIC AGENT | RESPONSES | VISCERAL HYPERSENSITIVITY | CORTICOTROPIN-RELEASING FACTOR | PHARMACOLOGICAL PROFILE | GASTROENTEROLOGY & HEPATOLOGY | 5-HT3 receptor antagonist | COLORECTAL DISTENSION | INDUCED DEFECATION | IRRITABLE-BOWEL-SYNDROME | Receptors, Opioid - agonists | Rats, Wistar | Colon - drug effects | Analgesics, Opioid - pharmacology | Male | Muscarinic Antagonists - therapeutic use | Dose-Response Relationship, Drug | Polymers - therapeutic use | Receptors, Opioid - physiology | Muscarinic Antagonists - pharmacology | Stress, Psychological - metabolism | Hyperalgesia - metabolism | Stress, Psychological - drug therapy | Rats | Serotonin Antagonists - therapeutic use | Analgesics, Opioid - therapeutic use | Serotonin 5-HT3 Receptor Antagonists | Serotonin Antagonists - pharmacology | Colon - metabolism | Animals | Hyperalgesia - drug therapy | Receptors, Serotonin, 5-HT3 - metabolism | Polymers - pharmacology | Hyperalgesia - etiology | Diarrhea - metabolism | Diarrhea - drug therapy | Stress, Psychological - complications
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1388 - 1400
Background and Purpose Chemotherapeutic agents, including 5‐fluorouracil (5‐FU), frequently cause intestinal mucositis resulting in severe diarrhoea and... 
5‐HT3 receptors | ondansetron | caspase‐8 | TNF‐α | intestinal mucositis | ramosetron | apoptosis | 5‐fluorouracil | caspase‐3 | RECOMMENDED GUIDELINES | caspase-8 | INVOLVEMENT | INDUCTION | TNF | CHEMOTHERAPY | 5-fluorouracil | PATHOGENESIS | INHIBITION | EXPERIMENTAL COLITIS | AVAILABILITY | 5-HT3 receptors | PHARMACOLOGY & PHARMACY | SEROTONIN | EXPRESSION | caspase-3 | Mucositis - metabolism | Intestinal Mucosa - metabolism | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Immunosuppressive Agents - therapeutic use | Gastrointestinal Agents - administration & dosage | Diarrhea - prevention & control | Male | Fluorouracil - antagonists & inhibitors | Mucositis - prevention & control | Intestinal Mucosa - drug effects | Serotonin 5-HT3 Receptor Antagonists - administration & dosage | Dose-Response Relationship, Drug | Fluorouracil - therapeutic use | Mucositis - pathology | Drug Interactions | Benzimidazoles - administration & dosage | Fluorouracil - adverse effects | Intestinal Mucosa - immunology | Apoptosis Regulatory Proteins - genetics | Benzimidazoles - adverse effects | Cytokines - genetics | Benzimidazoles - therapeutic use | Cytokines - metabolism | Mice, Inbred C57BL | Immunosuppressive Agents - antagonists & inhibitors | Mucositis - chemically induced | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Serotonin 5-HT3 Receptor Antagonists - therapeutic use | Antimetabolites, Antineoplastic - therapeutic use | Animals | Ondansetron - therapeutic use | Serotonin 5-HT3 Receptor Antagonists - adverse effects | Antimetabolites, Antineoplastic - adverse effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Gastrointestinal Agents - therapeutic use | Diarrhea - etiology | Immunosuppressive Agents - adverse effects | Mice | Ondansetron - adverse effects | Serotonin 5-HT3 Receptor Agonists - therapeutic use | Intestinal Mucosa - pathology | Serotonin 5-HT3 Receptor Agonists - adverse effects | Chemotherapy | Nausea | Cancer | Fluorouracil | Apoptosis | Research Papers | TNF-α
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 12/2009, Volume 21, Issue 12, pp. 1235 - 1238
Since metoclopramide was first described (in 1964) there have been several attempts to develop compounds which retained gastrointestinal prokinetic activity... 
constipation | prucalopride | 5‐HT4 | 5‐HT2B | 5‐HT3 | tegaserod | Prucalopride | 5-HT | Constipation | Tegaserod | 5-HT4 | PROFILE | 5-HT2B | GASTROENTEROLOGY & HEPATOLOGY | AGONISTS | NEUROSCIENCES | CLINICAL NEUROLOGY | 5-HT3
Journal Article