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index medicus (179) 179
humans (120) 120
biochemistry & molecular biology (117) 117
pre-messenger-rna (95) 95
base sequence (76) 76
rna splicing (76) 76
molecular sequence data (74) 74
animals (69) 69
alternative splicing (56) 56
cell biology (55) 55
5'-splice sites (52) 52
5'-splice-site recognition (52) 52
hela cells (51) 51
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rna precursors - metabolism (48) 48
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proteins (39) 39
genetics & heredity (37) 37
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5' splice-site (35) 35
u1 snrnp (35) 35
research (34) 34
ribonucleoprotein, u1 small nuclear - metabolism (33) 33
small nuclear ribonucleoprotein (33) 33
rna precursors - genetics (32) 32
rna splice sites (32) 32
premessenger rna (30) 30
serine-arginine splicing factors (30) 30
rna-binding proteins (28) 28
rna-binding proteins - metabolism (28) 28
amino acid sequence (26) 26
gene expression (26) 26
site selection (26) 26
binding sites (25) 25
rna, messenger - metabolism (24) 24
rna, small nuclear - metabolism (24) 24
rna-binding proteins - genetics (24) 24
nuclear proteins - metabolism (23) 23
rna splicing - genetics (23) 23
u1 snrna (23) 23
u6 snrna (23) 23
in-vivo (21) 21
nucleic acid conformation (21) 21
pre-mrna splicing (21) 21
selection (21) 21
cell line (20) 20
rna, small nuclear - genetics (20) 20
spliceosome (20) 20
spliceosomes - metabolism (20) 20
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genes (19) 19
in-vitro (19) 19
messenger rna (19) 19
ribonucleoprotein, u1 small nuclear - genetics (19) 19
5' splice site (18) 18
developmental biology (18) 18
identification (18) 18
nuclear proteins - genetics (18) 18
protein binding (18) 18
saccharomyces-cerevisiae (18) 18
5'-splice-site selection (17) 17
exon (17) 17
rna splice sites - genetics (16) 16
active-site (15) 15
expression (15) 15
gene expression regulation (15) 15
protein (15) 15
recognition (15) 15
ribonucleic acid--rna (15) 15
rna, messenger - genetics (15) 15
rna, small nuclear - chemistry (15) 15
5'-splice-site (14) 14
5′ splice site (14) 14
analysis (14) 14
base-pairing interaction (14) 14
biology (14) 14
genetic aspects (14) 14
introns - genetics (14) 14
multidisciplinary sciences (14) 14
phosphorylation (14) 14
ribonucleoproteins (14) 14
small nuclear rnas (14) 14
article (13) 13
conserved sequence (13) 13
physiological aspects (13) 13
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ribonucleoproteins - metabolism (13) 13
yeast (13) 13
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drosophila (12) 12
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hnrnp a1 (12) 12
mice (12) 12
molecular biology (12) 12
ribonucleoprotein, u1 small nuclear - chemistry (12) 12
t-cell intracellular antigen-1 (12) 12
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Journal Article
NATURE, ISSN 0028-0836, 03/1994, Volume 368, Issue 6467, pp. 119 - 124
Exactly how specific splice sites are recognized during the processing of complex precursor messenger RNAs is not clear. Small nuclear ribonucleoprotein... 
U1 SNRNA | 5' SPLICE SITE | COMPLEX | INVITRO | MULTIDISCIPLINARY SCIENCES | ASSEMBLY PATHWAY | BINDING PROTEINS | PURIFICATION | SMALL NUCLEAR RIBONUCLEOPROTEIN | FACTOR SC35 | PRE-MESSENGER-RNA
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 04/1999, Volume 13, Issue 7, pp. 851 - 863
We have investigated the formation of prespliceosomal complex A in HeLa nuclear extracts on a splicing substrate containing an AT-AC (U12-type) intron from the... 
U12 snRNP | BRANCH SITE | U11 snRNP | DEVELOPMENTAL BIOLOGY | PRE-MESSENGER-RNA | AT-AC INTRON | CELL BIOLOGY | U1 SNRNP | IN-VIVO | ASSEMBLY PATHWAY | SR PROTEINS | GENETICS & HEREDITY | SMALL NUCLEAR RIBONUCLEOPROTEIN | U2 SNRNP | 5'-SPLICE-SITE RECOGNITION | spliceosome assembly | pre-mRNA splicing | A complex formation
Journal Article
SCIENCE, ISSN 0036-8075, 02/1995, Volume 267, Issue 5198, pp. 675 - 679
The guanine uracil (G.U) base pair that helps to define the 5'-splice site of group I introns is phylogenetically highly conserved. In such a wobble base pair,... 
CATALYTIC INTRONS | THERMOPHILA RIBOZYME | TERTIARY INTERACTIONS | ACTIVE-SITE | MULTIDISCIPLINARY SCIENCES | 2'-HYDROXYL GROUPS | RNA SUBSTRATE | KINETIC DESCRIPTION | 5' SPLICE-SITE | CHEMICAL SYNTHESIS | GROUP-I INTRON
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2018, Volume 71, Issue 6, pp. 1012 - 1026.e3
Pre-mRNA splicing is an essential step in the expression of most human genes. Mutations at the 5′ splice site (5′ss) frequently cause defective splicing and... 
U1 SNRNA | FAMILIAL DYSAUTONOMIA | EXON | SPINAL MUSCULAR-ATROPHY | GENE | RECOGNITION | COMPARATIVE GENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONSEQUENCES | MUTATIONS | 5'-SPLICE SITES | CELL BIOLOGY | RNA | Multiprocessing | Genes | Genomics | Cells | Index Medicus
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 05/1993, Volume 13, Issue 5, pp. 2677 - 2687
Very small vertebrate exons are problematic for RNA splicing because of the proximity of their 3' and 5' splice sites. In this study, we investigated the... 
SKELETAL-MUSCLE | 5' SPLICE SITE | NUCLEAR RIBONUCLEOPROTEIN PARTICLE | COLLAGEN GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPENSATORY BASE CHANGE | DOWNSTREAM EXON | TROPONIN-I GENE | NUCLEOTIDE-SEQUENCE | PRE-MESSENGER-RNA | SYNDROME TYPE-VII | CELL BIOLOGY
Journal Article