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5-aminolevulinate synthetase - genetics (445) 445
humans (351) 351
animals (349) 349
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biochemistry & molecular biology (173) 173
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heme - biosynthesis (148) 148
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heme (113) 113
5-aminolevulinate synthase (111) 111
5-aminolevulinate synthetase - biosynthesis (102) 102
anemia, sideroblastic - genetics (102) 102
delta-aminolevulinate synthase (101) 101
liver - enzymology (95) 95
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amino acid sequence (82) 82
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aminolevulinic acid - metabolism (56) 56
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liver (39) 39
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genetic diseases, x-linked - genetics (38) 38
genetics & heredity (38) 38
iron (38) 38
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biophysics (37) 37
escherichia coli - genetics (37) 37
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porphyrins - biosynthesis (36) 36
erythroid 5-aminolevulinate synthase (35) 35
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saccharomyces cerevisiae - genetics (35) 35
genetic aspects (34) 34
porphyrias - metabolism (34) 34
promoter regions, genetic (34) 34
sideroblastic anemia (34) 34
porphyrins - metabolism (33) 33
5-aminolevulinate synthetase - blood (32) 32
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porphobilinogen synthase - metabolism (30) 30
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hemin - pharmacology (28) 28
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x chromosome (28) 28
aged (27) 27
alas2 (27) 27
ferrochelatase - metabolism (27) 27
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iron-responsive element (25) 25
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Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2013, Volume 22, Issue 7, pp. 1280 - 1288
Journal Article
Blood, ISSN 0006-4971, 08/2011, Volume 118, Issue 6, pp. 1443 - 1451
Journal Article
Structure, ISSN 0969-2126, 04/2018, Volume 26, Issue 4, pp. 580 - 589.e4
5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from . In this... 
ClpX | AAA+ unfoldase | porphyria | XLSA | XLPP | α-oxoamine family | sideroblastic anemia | BIOCHEMISTRY & MOLECULAR BIOLOGY | LINKED SIDEROBLASTIC ANEMIA | 5-AMINOLEVULINATE SYNTHASE | GLYCINE LOOP | FEATURES | CELL BIOLOGY | PHOSPHATE COFACTOR-BINDING | BIOPHYSICS | METABOLISM | SUCCINYL-COA SYNTHETASE | PURIFICATION | MUTATIONS | DOMINANT PROTOPORPHYRIA | Pyridoxal Phosphate - chemistry | Mitochondria - enzymology | Aminolevulinic Acid - chemistry | Saccharomyces cerevisiae - genetics | Protein Multimerization | Substrate Specificity | Crystallography, X-Ray | Protein Subunits - metabolism | Pyridoxal Phosphate - metabolism | Coenzymes - metabolism | Heme - chemistry | Mitochondria - genetics | Aminolevulinic Acid - metabolism | Heme - biosynthesis | Cloning, Molecular | Escherichia coli - metabolism | 5-Aminolevulinate Synthetase - metabolism | Protein Interaction Domains and Motifs | Coenzymes - chemistry | Mitochondria - chemistry | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | 5-Aminolevulinate Synthetase - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - chemistry | Amino Acid Motifs | Protein Conformation, beta-Strand | Escherichia coli - genetics | 5-Aminolevulinate Synthetase - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein Subunits - chemistry | Kinetics | Mutation | Amino Acid Substitution | Saccharomyces cerevisiae Proteins - chemistry | Phosphates | Enzymes | Anemia | Analysis | Heme | Crystals | Hemoglobin synthesis | Structure | AAA+ | unfoldase | Sideroblastic anemia
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 09/2015, Volume 54, Issue 36, pp. 5617 - 5631
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2019, Volume 380, Issue 6, pp. 549 - 558
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1665 - 1669
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4386 - 15
Journal Article