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Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2013, Volume 23, Issue 19, pp. 5283 - 5289
A series of novel I--aminophosphonate derivatives containing DHA structure were designed and synthesized as antitumor agents. In vitro antitumor activities of... 
5-Fluorouracil
Journal Article
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 12/2013, Volume 40, Issue 12, pp. 1853 - 1860
Purpose: The aim of the study was to investigate the feasibility of shortening the recommended 4-h renoprotective amino acid infusion in patients receiving... 
5-Fluorouracil
Journal Article
European journal of pharmacology, ISSN 0014-2999, 12/2012, Volume 696, Issue 1a3, pp. 172 - 178
Increased risk of anticancer chemotherapy in seriously obese patients is known. Obesity may be among factors that predict treatment-related toxicity during... 
5-Fluorouracil
Journal Article
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 12/2013, Volume 72, Issue 6, pp. 1273 - 1282
Purpose: Up to 30 % of patients undergoing 5-fluorouracil (5FU)-based chemotherapy experience severe toxicity. Dihydropyrimidine dehydrogenase (DPD) deficiency... 
5-Fluorouracil
Journal Article
NMR in biomedicine, ISSN 0952-3480, 02/2013, Volume 26, Issue 2, pp. 204 - 212
Hepatic steatosis is a hallmark of chemotherapy-induced liver injury. We made serial super(1)H MRS measurements of hepatic lipids in patients over the time... 
5-Fluorouracil
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 07/2011, Volume 410, Issue 3, pp. 563 - 567
Renal cell carcinoma (RCC) is chemoresistant cancer. Although several clinical trials were conducted to explore effective medications, the chemoresistance of... 
5-Fluorouracil
Journal Article
by Du, L and Jin, Y and Yang, J and Wang, S and Wang, X
Anti-cancer drugs, ISSN 0959-4973, 02/2013, Volume 24, Issue 2, pp. 172 - 180
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell... 
5-Fluorouracil
Journal Article
Clinical pharmacology and therapeutics, ISSN 0009-9236, 02/2018, Volume 103, Issue 2, pp. 210 - 216
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Analysis | Clinical pharmacology | Genotype | Research | Oxidoreductases | Chromosomes | Testing | Index Medicus | Abridged Index Medicus | 5-fluorouracil | capecitabine | dihydropyrimidine dehydrogenase | DPYD | fluoropyrimidines | CPIC | DPD | tegafur | pharmacogenetics
Journal Article
5-Fluorouracil, Epirubicin and Cisplatin in the Treatment of Metastatic Gastric Carcinoma: A Retrospective Analysis of 68 Patients, 12/2005
BACKGROUND: Gastric cancer is one of the most common types of cancer and one of the most frequent causes of cancer-related death. The majority of gastric... 
Metastatic gastric cancer, 5-Fluorouracil, Epirubicin, Cisplatin
Journal
ORIGINAL ARTICLE - TOXIC EFFECTS OF 5-FLUOROURACIL ON SPERM COUNT IN WISTAR RATS, 01/2003
The antimetabolite, 5-fluorouracil is widely used in the treatment of cancers. Although its toxic effects on testis causing germinal epithelial sloughing,... 
Health | 5-fluorouracil, sperm count, epididymis mj03006
Journal
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 10, pp. 8887 - 8897
Resistance to 5-Fluorouracil (5-FU) based chemotherapy is the major reason for failure of treating patients with advanced colorectal cancer. In this study, we... 
5-fluorouracil | MiR-129 | Cancer stem cells | Chemoresistance | Colorectal cancer
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 26, pp. 18239 - 18253
5-FU chemotherapy is a current strategy to treat pancreatic cancer (PC), but unfortunately chemoresistance is eventually developed in most patients. Obesity is... 
Cytotoxicity | 5-Fluorouracil | Leptin | Pancreatic cancer | Notch
Journal Article
Journal of the Medical Society of Toho University, ISSN 0040-8670, 09/2016, Volume 63, Issue 3, pp. 180 - 181
Journal Article
Neoplasia (New York, N.Y.), ISSN 1476-5586, 03/2018, Volume 20, Issue 3, pp. 263 - 279
Target-specific treatment modalities are currently not available for triple-negative breast cancer (TNBC), and acquired chemotherapy resistance is a primary... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell survival | Bcl-2 protein | Transcription | 5-Fluorouracil | Hsp70 protein | Breast cancer | Drug resistance | Autophagy | Cancer therapies | Doxorubicin | Mcl-1 protein | Cell adhesion & migration | Chemotherapy | Bcl-x protein | Cell death | Cell adhesion | Phagocytosis | Apoptosis | Tumors | Index Medicus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2008, Volume 13, Issue 8, pp. 1551 - 1569
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main... 
Resistance | 5-Fluorouracil | Microarray | Mechanism | Therapeutic strategies | Fluorouracil - therapeutic use | Drug Resistance, Neoplasm - genetics | Antineoplastic Agents - pharmacology | Fluorouracil - pharmacology | Gene Expression Profiling | Humans | Index Medicus | microarray | mechanism | resistance | therapeutic strategies
Journal Article