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MITOCHONDRION, ISSN 1567-7249, 03/2015, Volume 21, pp. 113 - 121
Extra-neurological functions of melatonin include control of the immune system and modulation of apoptosis. We previously showed that melatonin inhibits the... 
Bcl-2 | CANCER-CELLS | MESSENGER ROLE | Melatonin | OXIDATIVE STRESS | ACTIVATION | GSH EXTRUSION | BONE-MARROW | HL-60 CELLS | 5-HETE | ARACHIDONIC-ACID | CA-2&-DEPENDENT PROTEIN-KINASE | IP3 | CELL BIOLOGY | SIGNAL-TRANSDUCTION | GENETICS & HEREDITY | Bax | Apoptosis
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2013, Volume 138, Issue 3, pp. 485 - 502
The large variety of biological functions governed by prostaglandin (PG) E is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The... 
Vascular disease | Osteoporosis | Prostaglandins | Inflammation | Renal function | Cancerogenesis | HUMAN DENDRITIC CELLS | DIETARY SALT INTAKE | DUODENAL BICARBONATE SECRETION | MICROVASCULAR ENDOTHELIAL-CELLS | PROSTAGLANDIN-E-RECEPTOR | AGONIST-INDUCED INTERNALIZATION | BREAST-CANCER CELLS | INFLAMMATORY-BOWEL-DISEASE | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Neoplasms - metabolism | Receptors, Prostaglandin E, EP4 Subtype - agonists | Lung Diseases - metabolism | Cardiovascular Diseases - metabolism | Humans | Bone Diseases - metabolism | Dinoprostone - metabolism | Animals | Gastrointestinal Diseases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors | Immunologic Factors - metabolism | Kidney Diseases - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | CREB, cAMP-response element-binding protein | Associate editor | TX, thromboxane receptor | EPRAP, EP4 receptor-associated protein | PK, protein kinase | COX, cyclooxygenase | AMPK, AMP-activated protein kinase | ICAM-1, intercellular adhesion molecule-1 | PI3K, phosphatidyl insositol 3-kinase | CFTR, cystic fibrosis transmembrane conductance regulator | IP, I-type prostanoid receptor | Epac, exchange protein activated by cAMP | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | NSAID, non-steroidal anti-inflammatory drug | IFN, interferon | MEK, MAP kinase kinase | PG, prostaglandin | DSS, dextran sodium sulfate | eNOS, endothelial nitric oxide synthase | Ig, immunoglobulin | P. Holzer | ICER, inducible cAMP early repressor | EGFR, epidermal growth factor receptor | FEM1a, feminization 1 homolog a | ERK, extracellular signal-regulated kinase | MCP, monocyte chemoattractant protein | 5-HETE, 5-hydroxyeicosatetraenoic acid | IL, interleukin | GRK, G protein-coupled receptor kinase | MAP, mitogen-activated protein kinase | LPS, lipopolysaccharide | ClC, chloride channel | DP, D-type prostanoid receptor | FP, F-type prostanoid receptor | TP, T-type prostanoid receptor | cAMP, cyclic adenylyl monophosphate | EP, E-type prostanoid receptor
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 01/2006, Volume 393, Issue Pt 1, pp. 211 - 218
FLAP (5-lipoxygenase-activating protein) is a nuclear transmembrane protein involved in the biosynthesis of LTs (leukotrienes) and other 5-LO (5-lipoxygenase)... 
TRANSLOCATION | POLYMORPHONUCLEAR LEUKOCYTES | ACTIVATING PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | arachidonic acid (AA) | 5-hpoxygenase (5-LO) | ARACHIDONIC-ACID | prostaglandin B2 (PGB2) | IDENTIFICATION | 5-lipoxygenase-activating protein (FLAP) | NUCLEAR-MEMBRANE | polymorphonuclear cells (PMN) | INHIBITION | leukotriene (LT) | METABOLISM | BINDING | MEMBRANE ASSOCIATION | Cell Line | Arachidonic Acid - metabolism | Humans | Carrier Proteins - antagonists & inhibitors | Leukotrienes - biosynthesis | Animals | Carrier Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | 5-Lipoxygenase-Activating Proteins | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Dimerization | Neutrophils - metabolism | 5-HpETE, 5-hydroperoxyETE | PGB2, prostaglandin B2 | FLAP, 5-lipoxygenase-activating protein | NP40, Nonidet P40 | MAPEG, membrane-associated protein in eicosanoid and glutathione metabolism | LT, leukotriene | sulpho-HSAB, N-hydroxysulphosuccinimidyl-4-azidobenzoate | PMN, polymorphonuclear cells | sulpho-SADP, N-sulphosuccinimidyl-(4-azidophenyl)-1,3′-dithiopropionate | AA, arachidonic acid | 5-LO, 5-lipoxygenase | 5-HETE, 5-hydroxyeicosatetraenoic acid | FBS, foetal bovine serum | 5-lipoxygenase (5-LO) | NHS-ASA, N-hydroxysuccinimidyl-4-azidosalicylic acid | HBSS, Hanks' balanced salt solution | DFDNB, 1,5-difluoro-2,4-dinitrobenzene | PAF, platelet activating factor
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2005, Volume 389, Issue 2, pp. 279 - 287
Antioxidant enzymes play key roles in the protection of cells from oxidative damage. Little is known, however, about the expression of antioxidants and/or... 
Growth-regulated oncogene | Inflammation | Gene expression | Polymorphonuclear leucocyte | Phospholipid hydroperoxide glutathione peroxidase | Peroxide tone | Inflammation - chemically induced | Gene Expression Regulation, Enzymologic - drug effects | Glutathione Peroxidase - metabolism | Neutrophils - cytology | Neutrophils - enzymology | Down-Regulation | Neutrophils - drug effects | RNA, Messenger - genetics | Rats | Male | Macrophages - cytology | Oncogenes - physiology | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Glutathione Peroxidase - genetics | Hydrogen Peroxide - metabolism | Macrophages - enzymology | Up-Regulation - drug effects | Animals | Carrageenan - pharmacology | Macrophages - drug effects | Caseins - pharmacology | AMV, avian myeloblastosis virus | PHGPx, phospholipid hydroperoxide GPx | LOX, lipoxygenase | CHX, cycloheximide | phospholipid hydroperoxide glutathione peroxidase | PT, pertussis toxin | growth-regulated oncogene | HBSS, Hanks balanced salt solution | inflammation | PCOOH, phosphatidylcholine hydroperoxide | DHR 123, dihydrorhodamine 123 | GPx, glutathione peroxidase | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PG, prostaglandin | peroxide tone | GST, glutathione S-transferase | H2DCFDA, 5,6-carboxy-2,7-dichlorodihydrofluorescein diacetate | DCFDA, 5,6-carboxy-2,7-dichlorofluorescein diacetate | RBL-2H3, rat basophilic leukaemia 2H3 | LT, leukotriene | SOD, superoxide dismutase | cGPx, cytosolic GPx, GRO, growth-regulated oncogene | polymorphonuclear leucocyte | IL-1ra, IL-1 receptor antagonist | 5-HETE, 5-hydroxyeicosatetraenoic acid | IL, interleukin | FBS, foetal bovine serum | PMN, polymorphonuclear leucocyte | gene expression | MAPK, mitogen-activated protein kinase
Journal Article
JOURNAL OF PHARMACOBIO-DYNAMICS, ISSN 0386-846X, 06/1991, Volume 14, Issue 6, pp. 327 - 334
The effects of thirty-one synthetic dyes (tar dyes in Japan), which are permitted in cosmetics, on three different enzymes were evaluated as an initial step in... 
PGE2 | PG-SYNTHETASE | PROSTAGLANDIN (PG) | UNSATURATED FATTY-ACIDS | SYNTHETIC DYE | 5-HYDROXYEICOSATETRAENOIC ACID (5-HETE) | LIPOXYGENASE | INHIBITION | AZO DYE | COSMETIC | BIOSYNTHESIS | PHARMACOLOGY & PHARMACY | K TU PHARMACOLOGY & PHARMACY | SKIN | TAR DYE | XANTHENE DYE
Journal Article
Prostaglandins, ISSN 0090-6980, 1989, Volume 37, Issue 5, pp. 539 - 551
Journal Article
Prostaglandins, ISSN 0090-6980, 1989, Volume 37, Issue 5, pp. 539 - 551
Journal Article
Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, ISSN 0005-2760, 1982, Volume 712, Issue 1, pp. 42 - 47
Since mouse mast tumor P-815 cells produce the slow reacting substance of anaphylaxis, their 5-lipoxygenase activity was examined by determining the conversion... 
5-HETE | Lipoxygenase | 12-HETE | Mastocytoma cell
Journal Article
Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, 11/2017, Volume 126, pp. 1 - 8
Journal Article