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Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
European Urology Supplements, ISSN 1569-9056, 2003, Volume 2, Issue 1, pp. 36 - 36
Journal Article
Cancer Research, ISSN 0008-5472, 11/2002, Volume 62, Issue 22, pp. 6510 - 6518
The importance of estrogen-related receptors (ERRs) in human breast cancer was assessed by comparing their mRNA profiles with established clinicopathological... 
Journal Article
Genomics; (United States), ISSN 0888-7543, 07/1993, Volume 17:1
A role for the N-methyl-D-aspartate (NMDA) receptor in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of... 
MEMBRANE PROTEINS | BASIC BIOLOGICAL SCIENCES | ORGANIC COMPOUNDS | NEUROREGULATORS | AUTONOMIC NERVOUS SYSTEM AGENTS | CHROMOSOMES | HUMAN CHROMOSOME 8 | NERVOUS SYSTEM DISEASES | DISEASES | GENETIC MAPPING | 550400 - Genetics | HUMAN CHROMOSOME 9 | GENES | DRUGS | MAPPING | RECEPTORS | PROTEINS | HUMAN CHROMOSOMES
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 01/1993, Volume 7, Issue 1, pp. 37 - 46
We have identified two different single nucleotide missense substitutions at valine-865 in exon 7 of the human androgen receptor (AR) gene in two families with... 
Journal Article
Genomics, ISSN 0888-7543, 01/1993, Volume 17, Issue 1, pp. 237 - 239
A role for the N-methyl-D-aspartate (NMDA) receptor in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of... 
Journal Article
Cytogenetic and Genome Research, ISSN 1424-8581, 1995, Volume 71, Issue 1, pp. 77 - 80
Using fluorescence in situ hybridization, we determined the regional localization of the 3 rat genes encoding angiotensin II receptors at 17q12 (Agtr1a), 2q24... 
Animal Cytogenetics and Comparative Mapping | Animals | Humans | Hybrid Cells | Rats | X Chromosome | In Situ Hybridization, Fluorescence | Chromosome Mapping | Receptors, Angiotensin - genetics
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2004, Volume 370, Issue 2, pp. 114 - 123
In the present study we compared the affinity of various drugs for the high affinity “agonist-preferring” binding site of human recombinant 5-HT2A, 5-HT2B and... 
Agonist | Recombinant receptor | 5-HT 2A | Radioligand | LifeSciences | 5-HT 2C | 5-HT 2B | 5-HT | ANTAGONIST | RAT | agonist | 5HT(2C) RECEPTORS | radioligand | HUMAN 5-HYDROXYTRYPTAMINE(2B) RECEPTOR | IN-VITRO | MESSENGER-RNA | 5-HT2B | 5-HT2C | PHARMACOLOGY & PHARMACY | MULTIPLE SEROTONIN RECEPTORS | D-FENFLURAMINE | LSD | recombinant receptor | BRAIN | 5-HT2A
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 615, Issue 1, pp. 1 - 9
The serotonin 5-HT , 5-HT , and 5-HT G protein-coupled receptors signal primarily through G to activate phospholipase C (PLC) and formation of inositol... 
Drug addiction | Obesity | Drug discovery | Serotonin 5-HT 2 receptor | Psychiatric disorder
Journal Article
FASEB Journal, ISSN 0892-6638, 1996, Volume 10, Issue 6, p. A1291
Journal Article
CYTOGENETICS AND CELL GENETICS, ISSN 0301-0171, 1995, Volume 71, Issue 1, pp. 77 - 80
Using fluorescence in situ hybridization, we determined the regional localization of the 3 rat genes encoding angiotensin II receptors at 17q12 (Agtr1a), 2q24... 
GENETICS & HEREDITY | ASSIGNMENT | HYPERTENSIVE RATS | HYBRIDIZATION | LOCI | CELL BIOLOGY
Journal Article
Cytogenetics and Cell Genetics, ISSN 0301-0171, 01/1995, Volume 71, Issue 1, pp. 77 - 80
Using fluorescence in situ hybridization, we determined the regional localization of the 3 rat genes encoding angiotensin II receptors at 17q12 (Agtr1a), 2q24... 
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2008, Volume 594, Issue 1, pp. 32 - 38
Several examples of agonist-directed trafficking of receptor signalling at 5-HT and 5-HT receptors have been reported that involve independent downstream... 
Gq protein | Calcium release | Functional selectivity | Hallucinogen | 5-HT 2 receptor
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 2008, Volume 195, Issue 1, pp. 198 - 213
Journal Article
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