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Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6289 - 6300
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2013, Volume 169, Issue 6, pp. 1252 - 1262
Background and Purpose The 5‐HT3 receptor antagonist palonosetron is an important treatment for emesis and nausea during cancer therapy. Its clinical efficacy... 
cancer therapy | irreversible antagonism | down‐regulation | receptor trafficking | emesis | endocytosis | 5‐HT3 receptor | palonosetron | allosterism | receptor | down-regulation | 5-HT | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | PROTEIN-KINASE-C | CHEMOTHERAPY-INDUCED NAUSEA | HUMAN PLASMA | PHASE-III | ONDANSETRON | IN-VITRO | MODERATELY EMETOGENIC CHEMOTHERAPY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | EXPRESSION | 5-HT3 receptor | Receptors, Serotonin, 5-HT3 - chemistry | Allosteric Regulation | Humans | Serotonin 5-HT3 Receptor Antagonists - metabolism | Cercopithecus aethiops | Protein Transport - drug effects | Isoquinolines - pharmacology | Nystatin - pharmacology | Cell Membrane - metabolism | Radioligand Assay | Granisetron - pharmacology | Cell Membrane - drug effects | Isoquinolines - metabolism | Recombinant Proteins - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Endocytosis - drug effects | Quinuclidines - pharmacology | Recombinant Proteins - chemistry | Down-Regulation - drug effects | Hydrazones - pharmacology | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Granisetron - metabolism | Kinetics | Serotonin 5-HT3 Receptor Antagonists - pharmacology | COS Cells | Quinuclidines - metabolism | Antiemetics - pharmacology | Health aspects | Nausea | Enzyme-linked immunosorbent assay | Binding sites | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 736 - 747
The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit results in heteromeric 5‐HT3AB receptors that are functionally distinct... 
5‐HT3A | 5‐HT3B | allosteric | 5‐HT3 | 5‐HT3AB | ion channel | Cys‐loop | ligand gated | antagonist | ligand | 5-HT3AB | 5-HT | 5-HT3A | Cys-loop | 5-HT3B | GATED ION-CHANNEL | 5-HYDROXYTRYPTAMINE TYPE-3 RECEPTORS | SEROTONIN 5-HT3 | CYS-LOOP RECEPTORS | MOLECULAR DETERMINANTS | NEUROBLASTOMA-CELLS | STRUCTURAL DETERMINANTS | 5-HT3 | 5-HTAB RECEPTORS | GABA(A) RECEPTOR | PHARMACOLOGY & PHARMACY | LIGAND-BINDING SITE | Receptors, Serotonin, 5-HT3 - chemistry | Humans | Molecular Conformation | Protein Multimerization | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Serotonin 5-HT3 Receptor Antagonists - metabolism | Serotonin 5-HT3 Receptor Agonists - metabolism | Protein Subunits - metabolism | Antiemetics - therapeutic use | Antiemetics - chemistry | Serotonin 5-HT3 Receptor Antagonists - chemistry | Binding Sites - drug effects | Protein Subunits - genetics | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Drug Partial Agonism | Receptors, Serotonin, 5-HT3 - genetics | Models, Molecular | Recombinant Proteins - chemistry | Binding, Competitive - drug effects | Serotonin 5-HT3 Receptor Antagonists - therapeutic use | Animals | Antiemetics - metabolism | Receptors, Serotonin, 5-HT3 - metabolism | Ligands | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Serotonin 5-HT3 Receptor Antagonists - pharmacology | Serotonin 5-HT3 Receptor Agonists - therapeutic use | Antiemetics - pharmacology | Competition | Reviews
Journal Article
Pharmacological Research, ISSN 1043-6618, 11/2015, Volume 101, pp. 65 - 73
Ligand-gated ion channels (LGICs) are cell surface integral proteins that mediate the fast neurotransmission in the nervous system. LGICs require auxiliary... 
Auxiliary subunits | Pharmacological modulation | LGICs | AMPA RECEPTOR | ACETYLCHOLINE-RECEPTOR | KAINATE RECEPTORS | GLYCINE RECEPTORS | ACID TYPE-A | P2X RECEPTOR | ION-CHANNEL | PHARMACOLOGY & PHARMACY | GABA(A) RECEPTORS | NEURONAL NICOTINIC RECEPTORS | BETA-SUBUNIT | Receptors, Glutamate - metabolism | Protein Subunits | Receptors, Serotonin, 5-HT3 - chemistry | Receptors, Kainic Acid - chemistry | Receptors, Purinergic P2X - chemistry | Humans | Receptors, AMPA - chemistry | Receptors, N-Methyl-D-Aspartate - metabolism | Receptors, GABA-A - chemistry | Receptors, Purinergic P2X - drug effects | Receptors, Glutamate - drug effects | Receptors, Glycine - drug effects | Receptors, Nicotinic - chemistry | Receptors, N-Methyl-D-Aspartate - chemistry | Receptors, GABA-A - drug effects | Receptors, Purinergic P2X - metabolism | Receptors, Glycine - chemistry | Receptors, Glycine - metabolism | Ligand-Gated Ion Channels - metabolism | Receptors, Kainic Acid - drug effects | Receptors, Serotonin, 5-HT3 - drug effects | Receptors, AMPA - metabolism | Receptors, N-Methyl-D-Aspartate - drug effects | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Ligand-Gated Ion Channels - chemistry | Models, Molecular | Receptors, Glutamate - chemistry | Receptors, Kainic Acid - metabolism | Animals | Receptors, Serotonin, 5-HT3 - metabolism | Receptors, GABA-A - metabolism | Ligand-Gated Ion Channels - drug effects | Receptors, AMPA - drug effects | Ion Channel Gating - drug effects
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
Journal Article
Anesthesiology, ISSN 0003-3022, 2000, Volume 93, Issue 4, pp. 1095 - 1101
Background: Ligand-gated ion channels are considered to be potential general anesthetic targets. Although most general anesthetics potentiate the function of... 
Serotonin | Electrophysiology | Excitatory amino acids | POTENCIES | excitatory amino acids | CURRENTS | NICOTINIC ACETYLCHOLINE-RECEPTORS | FLUORINATED ALKANOLS | serotonin | electrophysiology | CLONING | FUNCTIONAL EXPRESSION | GLUTAMATE | VOLATILE ANESTHETICS | ANESTHESIOLOGY | GABA(A) RECEPTORS | SUBUNIT | Receptors, Serotonin - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Xenon - pharmacology | Isoflurane - pharmacology | Humans | Receptors, Serotonin - drug effects | Ion Channels - genetics | Ion Channels - physiology | Receptors, Kainic Acid - antagonists & inhibitors | Receptors, Kainic Acid - genetics | Receptors, Neurotransmitter - genetics | Receptors, Neurotransmitter - physiology | Receptors, Serotonin - genetics | Receptors, Glycine - antagonists & inhibitors | Receptors, N-Methyl-D-Aspartate - genetics | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Receptors, GABA-A - drug effects | Female | Receptors, AMPA - genetics | Anesthetics, Inhalation - pharmacology | Receptors, Nicotinic - drug effects | GABA-A Receptor Antagonists | Receptors, AMPA - physiology | Receptors, Glycine - physiology | Receptors, Neurotransmitter - antagonists & inhibitors | Xenopus laevis | Nitrous Oxide - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Ion Channels - antagonists & inhibitors | Ethanol - pharmacology | Receptors, Serotonin, 5-HT3 | Animals | Receptors, Nicotinic - physiology | Receptors, GABA-A - physiology | Receptors, Kainic Acid - physiology | Receptors, Glycine - genetics | Receptors, Nicotinic - genetics | Ion Channel Gating - drug effects | Receptors, AMPA - antagonists & inhibitors
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2008, Volume 28, Issue 31, pp. 7808 - 7819
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 9/2011, Volume 333, Issue 6047, pp. 1292 - 1296
Ionic flux mediates essential physiological and behavioral functions in defined cell populations. Cell type—specific activators of diverse ionic conductances... 
Brain | Receptors | Neurons | Drug interactions | REPORTS | Ligands | Ion channels | Pharmacology | Benzamides | Cholinergic receptors | Behavioral neuroscience | ACETYLCHOLINE-RECEPTORS | DESIGN | DOMAIN | PROTEIN | NEURONAL NICOTINIC RECEPTOR | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LOOP | MUTATIONS | IDENTIFICATION | Stereoisomerism | Humans | Benzamides - metabolism | Brain - physiology | Recombinant Fusion Proteins - metabolism | Bridged Bicyclo Compounds - chemistry | Receptors, Nicotinic - chemistry | HEK293 Cells | Neurons - physiology | Protein Engineering | Female | Benzamides - pharmacology | Receptors, Glycine - metabolism | Ligand-Gated Ion Channels - metabolism | Benzamides - chemistry | Protein Structure, Tertiary | Brain - cytology | Receptors, Nicotinic - metabolism | Receptors, Serotonin, 5-HT3 - genetics | Bridged Bicyclo Compounds - pharmacology | Ligand-Gated Ion Channels - chemistry | Mice, Inbred C57BL | Quinuclidines - pharmacology | Feeding Behavior | Recombinant Fusion Proteins - chemistry | Patch-Clamp Techniques | Animals | Membrane Potentials | Mutagenesis | Small Molecule Libraries | Bridged Bicyclo Compounds - metabolism | Ligand-Gated Ion Channels - genetics | Receptors, Serotonin, 5-HT3 - metabolism | Protein Binding | Mice | Quinuclidines - chemistry | Ion Channel Gating | Quinuclidines - metabolism | Receptors, Glycine - genetics | Receptors, Nicotinic - genetics | alpha7 Nicotinic Acetylcholine Receptor | Physiological aspects | Usage | Genetic engineering | Research | Animal behavior | Ligands (Biochemistry) | Ions | Cellular biology | Chemical engineering
Journal Article