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cytosine - analogs & derivatives (1305) 1305
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azacitidine - pharmacology (66) 66
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1. Full Text DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
by Rampal, Raajit and Alkalin, Altuna and Madzo, Jozef and Vasanthakumar, Aparna and Pronier, Elodie and Patel, Jay and Li, Yushan and Ahn, Jihae and Abdel-Wahab, Omar and Shih, Alan and Lu, Chao and Ward, Patrick S and Tsai, Jennifer J and Hricik, Todd and Tosello, Valeria and Tallman, Jacob E and Zhao, Xinyang and Daniels, Danette and Dai, Qing and Ciminio, Luisa and Aifantis, Iannis and He, Chuan and Fuks, Francois and Tallman, Martin S and Ferrando, Adolfo and Nimer, Stephen and Paietta, Elisabeth and Thompson, Craig B and Licht, Jonathan D and Mason, Christopher E and Godley, Lucy A and Melnick, Ari and Figueroa, Maria E and Levine, Ross L
Cell reports (Cambridge), ISSN 2211-1247, 12/2014, Volume 9, Issue 5, pp. 1841 - 1855
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cytosine - analogs & derivatives | Promoter Regions, Genetic | DNA-Binding Proteins - physiology | 5-Methylcytosine - analogs & derivatives | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Sequence Analysis, DNA | Mice, Knockout | Animals | Enhancer Elements, Genetic | Hematopoiesis | Proto-Oncogene Proteins - physiology | Protein Binding | Cell Differentiation | Mutation | WT1 Proteins - genetics | Cytosine - physiology | Leukemia, Myeloid, Acute - genetics | Index Medicus | AML | Epigenetics | TET2 | WT1 | hydroxymethylation
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2. Full Text TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis
by Mahfoudhi, Emna and Talhaoui, Ibtissam and Cabagnols, Xenia and Della Valle, Véronique and Secardin, Lise and Rameau, Philippe and Bernard, Olivier A and Ishchenko, Alexander A and Abbes, Salem and Vainchenker, William and Saparbaev, Murat and Plo, Isabelle
DNA repair, ISSN 1568-7864, 07/2016, Volume 43, pp. 78 - 88
TET2 | Genetic instability | 5-hmC | TDG | Cell cycle | Toxicology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cytosine - analogs & derivatives | Genomic Instability | 5-Methylcytosine - analogs & derivatives | Epigenesis, Genetic | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Cytosine - metabolism | Base Sequence | S Phase | Thymine DNA Glycosylase - genetics | B-Lymphocytes - metabolism | Megakaryocyte Progenitor Cells - cytology | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | B-Lymphocytes - cytology | Hydroxylation | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Megakaryocyte Progenitor Cells - metabolism | Animals | 5-Methylcytosine - metabolism | Mutagenesis | DNA Repair | Thymine DNA Glycosylase - deficiency | Fibroblasts - cytology | Mice | Index Medicus | Megakaryocyte Progenitor Cells/metabolism | Thymine DNA Glycosylase/genetics | Proto-Oncogene Proteins/genetics | Cytosine/metabolism | B-Lymphocytes/metabolism | Genomics | Cytosine/analogs & derivatives | Tumor Suppressor Protein p53/metabolism | DNA-Binding Proteins/metabolism | B-Lymphocytes/cytology | Life Sciences | Thymine DNA Glycosylase/deficiency | Fibroblasts/metabolism | Fibroblasts/cytology | Biochemistry, Molecular Biology | 5-Methylcytosine/metabolism | Proto-Oncogene Proteins/metabolism | Tumor Suppressor Protein p53/genetics | Megakaryocyte Progenitor Cells/cytology | 5-Methylcytosine/analogs & derivatives | DNA-Binding Proteins/genetics
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3. Full Text Simultaneous quantitative determination of 5-aza-2′-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors
by Anders, Nicole M and Liu, Jianyong and Wanjiku, Teresia and Giovinazzo, Hugh and Zhou, Jianya and Vaghasia, Ajay and Nelson, William G and Yegnasubramanian, Srinivasan and Rudek, Michelle A
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ISSN 1570-0232, 06/2016, Volume 1022, pp. 38 - 45
DNA methyltransferase inhibitor | LC/MS/MS | Global DNA demethylation | 5-Methylcytosine | Genomic DNA | 5-Aza-2′-deoxycytidine | Decitabine | 5-Methyl-2′-deoxycytidine | 5-Aza-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Limit of Detection | Reproducibility of Results | Humans | Azacitidine - chemistry | Azacitidine - analogs & derivatives | Linear Models | DNA - metabolism | 5-Methylcytosine - chemistry | Azacitidine - analysis | DNA - chemistry | Animals | Methyltransferases - antagonists & inhibitors | 5-Methylcytosine - metabolism | DNA - analysis | Mice, Nude | Cell Line, Tumor | Mice | Azacitidine - metabolism | Chromatography, Liquid - methods | DNA Methylation - physiology | Tandem Mass Spectrometry - methods | Measurement | Medical colleges | Transferases | DNA | Nucleosides | Genetic research | Respiratory tract diseases | Liquid chromatography | Mass spectrometry | Methyltransferases | Analysis | Formic acid | Physiological aspects | Methylation | Index Medicus | Enzymes | Inhibitors | Deoxyribonucleic acid | In vivo methods and tests | Exposure | Assaying | Chromatography | genomic DNA | global DNA demethylation | MS | LC | 5-methylcytosine | decitabine | 5-methyl-2′-deoxycytidine | 5-aza-2′-deoxycytidine
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4. Full Text Nucleic Acid Modifications in Regulation of Gene Expression
by Chen, Kai and Zhao, Boxuan Simen and He, Chuan
Cell chemical biology, ISSN 2451-9456, 01/2016, Volume 23, Issue 1, pp. 74 - 85
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Cytidine - analogs & derivatives | Adenine - chemistry | Pseudouridine - metabolism | Adenosine - genetics | RNA - genetics | Pseudouridine - genetics | DNA Methylation | Cytidine - genetics | Adenosine - chemistry | RNA - metabolism | Pseudouridine - chemistry | Adenine - analogs & derivatives | Cytidine - chemistry | Gene Expression Regulation | DNA - metabolism | RNA - chemistry | 5-Methylcytosine - chemistry | DNA - genetics | DNA - chemistry | Animals | 5-Methylcytosine - metabolism | Adenosine - analogs & derivatives | Adenosine - metabolism | Cytidine - metabolism | Adenine - metabolism | Cell research | Genetic aspects | Nucleic acids | Research | Genetic regulation | Gene expression
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5. Full Text Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
by Hashimoto, Hideharu and Liu, Yiwei and Upadhyay, Anup K and Chang, Yanqi and Howerton, Shelley B and Vertino, Paula M and Zhang, Xing and Cheng, Xiaodong
Nucleic acids research, ISSN 0305-1048, 06/2012, Volume 40, Issue 11, pp. 4841 - 4849
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Cytosine - analogs & derivatives | Cytosine - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Pentoxyl - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | Humans | DNA Replication | Pentoxyl - metabolism | Thymine DNA Glycosylase - metabolism | Index Medicus | DNA biosynthesis | Translocation | Thymine DNA glycosylase | Deamination | DNMT1 protein | DNA methyltransferase | Replication | Cytosine | DNA glycosylase | CpG islands | Gene Regulation, Chromatin and Epigenetics
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6. Full Text The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
by Skirmantas Kriaucionis and Nathaniel Heintz
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2009, Volume 324, Issue 5929, pp. 929 - 930
Brain | Neurons | Purkinje cells | DNA | Cell nucleus | Cell lines | Epigenetics | Nucleosides | Reports | Nucleotides | Nucleic acids | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Biological and medical sciences | Cell Line | Cytosine - analogs & derivatives | Deoxycytidine - analysis | 5-Methylcytosine - analogs & derivatives | Humans | Chromatography, High Pressure Liquid | Chromatography, Thin Layer | Purkinje Cells - chemistry | DNA - chemistry | Animals | Mass Spectrometry | Cerebellum - cytology | Brain Chemistry | Cerebellum - chemistry | Mice | DNA Damage | Cytosine - analysis | Deoxycytidine - analogs & derivatives | Chromatin | Genetic aspects | Research | Cellular biology | Deoxyribonucleic acid--DNA | Index Medicus
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7. Full Text CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
by Zauri, Melania and Berridge, Georgina and Thézénas, Marie-Laëtitia and Pugh, Kathryn M and Goldin, Robert and Kessler, Benedikt M and Kriaucionis, Skirmantas
Nature (London), ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 114 - 118
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Phosphotransferases - metabolism | Cytosine - analogs & derivatives | Up-Regulation | Epigenesis, Genetic | Humans | Uridine - analogs & derivatives | Gene Expression Regulation, Neoplastic | Cytidine - pharmacology | Substrate Specificity | Deoxycytidine - pharmacology | Cytidine - analogs & derivatives | Nucleotides - chemistry | Deoxycytidine - metabolism | Neoplasms - genetics | Cytosine - metabolism | Nucleotides - pharmacology | DNA - biosynthesis | Cytosine - pharmacology | Cell Death - drug effects | Uridine - chemistry | DNA Damage - drug effects | Cytidine - chemistry | Oxidation-Reduction | Cytidine Deaminase - genetics | Cytosine - chemistry | Nucleotides - metabolism | Neoplasms - drug therapy | Gene Expression Regulation, Enzymologic | DNA - chemistry | Animals | 5-Methylcytosine - metabolism | 5-Methylcytosine - pharmacology | Cytidine Deaminase - metabolism | Cell Line, Tumor | Cytidine - metabolism | Uridine - metabolism | Mice | DNA-Directed DNA Polymerase - metabolism | Deoxycytidine - analogs & derivatives | Enzymes | Epigenetic inheritance | Care and treatment | Nucleosides | Genetic aspects | Metabolism | Health aspects | Methods | Cancer | DNA polymerase | Epigenetics | Cytotoxicity | Kinases | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus
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