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1. Full Text Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?
by Kotandeniya, D and Seiler, C.L and Fernandez, J and Pujari, S.S and Curwick, L and Murphy, K and Wickramaratne, S and Yan, S and Murphy, D and Sham, Yuk Y and Tretyakova, N.Y
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 9, pp. 1061 - 1064
5-Methylcytosine (C-Me) is an endogenous modification of DNA that plays a crucial role in DNA-protein interactions, chromatin structure, epigenetic regulation,... 
ACID RELATED-COMPOUNDS | URACIL BASES | P53 GENE | K-RAS | NUCLEOSIDES | 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE | ADDUCTS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | CYTOSINE METHYLATION | DAMAGE | DNA - chemistry | DNA Methylation | 5-Methylcytosine - analogs & derivatives | Humans | Models, Molecular | Crystallography, X-Ray | Molecular Structure | DNA - metabolism | 5-Methylcytosine - chemistry | DNA (Cytosine-5-)-Methyltransferase 1 - metabolism | Proteins | DNA methylation | Chains | Gene expression | Methylation | Deoxyribonucleic acid--DNA | Index Medicus
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2. Full Text Simultaneous quantitative determination of 5-aza-2′-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors
by Anders, Nicole M and Liu, Jianyong and Wanjiku, Teresia and Giovinazzo, Hugh and Zhou, Jianya and Vaghasia, Ajay and Nelson, William G and Yegnasubramanian, Srinivasan and Rudek, Michelle A
Journal of Chromatography B, ISSN 1570-0232, 06/2016, Volume 1022, pp. 38 - 45
The epigenetic and anti-cancer activities of the nucleoside analog DNA methyltransferase (DNMT) inhibitors decitabine (5-aza-2′-deoxycytidine, DAC),... 
DNA methyltransferase inhibitor | LC/MS/MS | Global DNA demethylation | 5-Methylcytosine | Genomic DNA | 5-Aza-2′-deoxycytidine | Decitabine | 5-Methyl-2′-deoxycytidine | 5-Aza-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine | CHEMISTRY, ANALYTICAL | 5-Aza-2 '-deoxycytidine | 5-AZACYTIDINE | BIOCHEMICAL RESEARCH METHODS | MECHANISMS | ACUTE MYELOID-LEUKEMIA | AZACITIDINE | CANCER | BLOOD MONONUCLEAR-CELLS | PRODUCTS | 5-Methyl-2 '-deoxycytidine | TRIPHOSPHATE | DEGRADATION | Limit of Detection | Reproducibility of Results | Humans | Azacitidine - chemistry | Azacitidine - analogs & derivatives | Linear Models | DNA - metabolism | 5-Methylcytosine - chemistry | Azacitidine - analysis | DNA - chemistry | Animals | Methyltransferases - antagonists & inhibitors | 5-Methylcytosine - metabolism | DNA - analysis | Mice, Nude | Cell Line, Tumor | Mice | Azacitidine - metabolism | Chromatography, Liquid - methods | DNA Methylation - physiology | Tandem Mass Spectrometry - methods | Measurement | Medical colleges | Transferases | DNA | Nucleosides | Genetic research | Respiratory tract diseases | Liquid chromatography | Mass spectrometry | Methyltransferases | Analysis | Formic acid | Physiological aspects | Methylation | Index Medicus | Enzymes | Inhibitors | Deoxyribonucleic acid | In vivo methods and tests | Exposure | Assaying | Chromatography | genomic DNA | global DNA demethylation | 5-methylcytosine | decitabine | 5-methyl-2′-deoxycytidine | 5-aza-2′-deoxycytidine
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3. Full Text Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases
by Sudhamalla, Babu and Wang, Sinan and Snyder, Valerie and Kavoosi, Sam and Arora, Simran and Islam, Kabirul
Journal of the American Chemical Society, ISSN 0002-7863, 08/2018, Volume 140, Issue 32, pp. 10263 - 10269
Ten-eleven translocation (TET) enzymes employ O-2 earth-abundant iron, and 2-ketoglutarate (2KG) to perform iterative C-H oxidation of 5-methylcytosine in DNA... 
OXIDATION | CELLS | CHEMICAL GENETICS | MAMMALIAN DNA | 5-METHYLCYTOSINE | CRYSTAL-STRUCTURE | DEMETHYLATION | KINASE | 5-HYDROXYMETHYLCYTOSINE | CHEMISTRY, MULTIDISCIPLINARY | 5-CARBOXYLCYTOSINE
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4. Full Text Quantification of the sixth DNA base hydroxymethylcytosine in the brain
by Münzel, Martin and Globisch, Daniel and Brückl, Tobias and Wagner, Mirko and Welzmiller, Veronika and Michalakis, Stylianos and Müller, Markus and Biel, Martin and Carell, Thomas
Angewandte Chemie - International Edition, ISSN 1433-7851, 07/2010, Volume 49, Issue 31, pp. 5375 - 5377
DNA methylation | Epigenetics | Demethylation | DNA modification | Hydroxymethylcytosine | demethylation | OXIDATION | METHYLATION | 5-METHYLCYTOSINE | hydroxymethylcytosine | PRODUCTS | ANALOGS | 5-HYDROXYMETHYLCYTOSINE | CHEMISTRY, MULTIDISCIPLINARY | epigenetics | Cytosine - analogs & derivatives | DNA - isolation & purification | DNA Methylation | Animals | DNA - analysis | 5-Methylcytosine - analogs & derivatives | Brain Chemistry | Mice | Cytosine - analysis | Index Medicus
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5. Full Text The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
by Skirmantas Kriaucionis and Nathaniel Heintz
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5929, pp. 929 - 930
Despite the importance of epigenetic regulation in neurological disorders, little is known about neuronal chromatin. Cerebellar Purkinje neurons have large and... 
Brain | Neurons | Purkinje cells | DNA | Cell nucleus | Cell lines | Epigenetics | Nucleosides | Reports | Nucleotides | Nucleic acids | CNS CELL-TYPES | OXIDATIVE DAMAGE | 5-METHYLCYTOSINE | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | Cell Line | Cytosine - analogs & derivatives | Deoxycytidine - analysis | 5-Methylcytosine - analogs & derivatives | Humans | Chromatography, High Pressure Liquid | Chromatography, Thin Layer | Purkinje Cells - chemistry | DNA - chemistry | Animals | Mass Spectrometry | Cerebellum - cytology | Brain Chemistry | Cerebellum - chemistry | Mice | DNA Damage | Cytosine - analysis | Deoxycytidine - analogs & derivatives | Chromatin | Genetic aspects | Research | Cellular biology | Deoxyribonucleic acid--DNA | Index Medicus
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6. Full Text Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
by Pfaffeneder, T and Spada, F and Wagner, M and Brandmayr, C and Laube, S.K and Eisen, D and Truss, M and Steinbacher, J and Hackner, B and Kotljarova, O and Schuermann, D and Michalakis, S and Kosmatchev, O and Schiesser, S and Steigenberger, B and Raddaoui, N and Kashiwazaki, G and Muller, U and Spruijt, C.G and Vermeulen, M and Leonhardt, H and Schar, P and Muller, M and Carell, T
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 7, pp. 574 - 581
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC),... 
GLYCOSYLASE | DEAMINATION | BASE EXCISION-REPAIR | MAMMALIAN DNA | 5-METHYLCYTOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYL-GROUP | PLURIPOTENCY | 5-CARBOXYLCYTOSINE | 5-FORMYLCYTOSINE | ACTIVE-DEMETHYLATION | Cytosine - analogs & derivatives | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | 5-Methylcytosine - analogs & derivatives | Carbon Isotopes | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Spectrometry, Mass, Electrospray Ionization | Cytosine - metabolism | Pentoxyl - analogs & derivatives | Base Sequence | Chromatography, Liquid | Thymine - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | Oxidation-Reduction | Chromatin Assembly and Disassembly | Proto-Oncogene Proteins - genetics | DNA - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Pentoxyl - metabolism | Transcription Factors - metabolism | Animals | Protein Binding | Mice | Proteins | Enzymes | Chromatin | Stem cells | Epigenetics | Embryos | Deoxyribonucleic acid--DNA | Index Medicus
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7. Full Text The discovery of 5-formylcytosine in embryonic stem cell DNA
by Pfaffeneder, Toni and Hackner, Benjamin and Truß, Matthias and Münzel, Martin and Müller, Markus and Deiml, Christian A and Hagemeier, Christian and Carell, Thomas
Angewandte Chemie - International Edition, ISSN 1433-7851, 07/2011, Volume 50, Issue 31, pp. 7008 - 7012
mass spectrometry | 5-formylcytosine | active demethylation | epigenetics | 5-hydroxymethylcytosine | METHYLATION | MEMORY FORMATION | 5-METHYLCYTOSINE | QUANTIFICATION | HYDROXYMETHYLCYTOSINE | TET1 | CHEMISTRY, MULTIDISCIPLINARY | GENOME | DEMETHYLATION | BRAIN | Cytosine - analogs & derivatives | DNA - chemistry | Embryonic Stem Cells - chemistry | Animals | 5-Methylcytosine - analogs & derivatives | Mass Spectrometry | Mice | Cytosine - analysis | Index Medicus
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8. Full Text Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
by Hashimoto, Hideharu and Liu, Yiwei and Upadhyay, Anup K and Chang, Yanqi and Howerton, Shelley B and Vertino, Paula M and Zhang, Xing and Cheng, Xiaodong
Nucleic Acids Research, ISSN 0305-1048, 06/2012, Volume 40, Issue 11, pp. 4841 - 4849
Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During... 
HUMAN UHRF1 | METHYLTRANSFERASE | BASE EXCISION-REPAIR | MAMMALIAN DNA | CPG-BINDING | HUMAN DNMT3L | GERM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SRA DOMAIN | ACTIVE DNA DEMETHYLATION | DE-NOVO METHYLATION | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Cytosine - analogs & derivatives | Cytosine - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | Pentoxyl - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | Humans | DNA Replication | Pentoxyl - metabolism | Thymine DNA Glycosylase - metabolism | Index Medicus | DNA biosynthesis | Translocation | Thymine DNA glycosylase | Deamination | DNMT1 protein | DNA methyltransferase | Replication | Cytosine | DNA glycosylase | CpG islands | Gene Regulation, Chromatin and Epigenetics
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9. Full Text Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
by Condliffe, Daniel and Wong, Andrew and Troakes, Claire and Proitsi, Petroula and Patel, Yogen and Chouliaras, Leonidas and Fernandes, Cathy and Cooper, Jonathan and Lovestone, Simon and Schalkwyk, Leonard and Mill, Jonathan and Lunnon, Katie
Neurobiology of Aging, ISSN 0197-4580, 2014, Volume 35, Issue 8, pp. 1850 - 1854
Abstract Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of... 
Neurology | Internal Medicine | Brain | 5-carboxylcytosine | 5-formylcytosine | 5-mC | 5-hmC | 5-hydroxymethylcytosine | Epigenetics | DNA methylation | 5-methylcytosine | 5-fC | 5-caC | Alzheimer's disease | NEUROSCIENCES | GENOME | GERIATRICS & GERONTOLOGY | REPLICATION | ROLES | GENES | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | Humans | Male | Brain - metabolism | Cytosine - metabolism | Epigenesis, Genetic - genetics | Alzheimer Disease - metabolism | Fluorescent Antibody Technique | Aged, 80 and over | Female | Ivermectin - analogs & derivatives | Aged | Alzheimer Disease - genetics | Methylation | Index Medicus
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10. Full Text 5-Hydroxymethylcytosine is a predominantly stable DNA modification
by Bachman, Martin and Uribe-Lewis, Santiago and Yang, Xiaoping and Williams, Michael and Murrell, Adele and Balasubramanian, Shankar
Nature Chemistry, ISSN 1755-4330, 2014, Volume 6, Issue 12, pp. 1049 - 1055
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells.... 
METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | BASE-RESOLUTION | DEMETHYLATION | EMBRYONIC STEM-CELLS | SELF-RENEWAL | HUMAN CANCERS | TET PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | GENOME | Cytosine - analogs & derivatives | Cell Proliferation | 5-Methylcytosine - analogs & derivatives | HCT116 Cells | Humans | Mice, Inbred C57BL | DNA - metabolism | Cytosine - chemistry | DNA Methylation | Animals | Cell Cycle | MCF-7 Cells | Mice | Index Medicus
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11. Full Text PCR amplification of GC-rich DNA regions using the nucleotide analog N-4-methyl-2 '-deoxycytidine 5 '-triphosphate
by Flores-Juarez, CR and Gonzalez-Jasso, E and Antaramian, A and Pless, RC
BIOTECHNIQUES, ISSN 0736-6205, 10/2016, Volume 61, Issue 4, pp. 175 - 182
GC-rich DNA regions were PCR-amplified with Taq DNA polymerase using either the canonical set of deoxynucleoside triphosphates or mixtures in which the dCTP... 
THERMAL-STABILITY | SPECIFICITY | SEQUENCES | 5-METHYLCYTOSINE | N4-METHYLCYTOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | BETAINE | BASE | IMPROVES | DIMETHYL-SULFOXIDE | N-4-methylcytosine | RESTRICTION ENDONUCLEASES | GC-rich DNA | PCR | dCTP analog
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12. Full Text CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
by Zauri, Melania and Berridge, Georgina and Thézénas, Marie-Laëtitia and Pugh, Kathryn M and Goldin, Robert and Kessler, Benedikt M and Kriaucionis, Skirmantas
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 114 - 118
Cells require nucleotides to support DNA replication and repair damaged DNA. In addition to de novo synthesis, cells recycle nucleotides from the DNA of dying... 
GLYCOSYLASE | REPLICATION | 5-METHYL-2'-DEOXYCYTIDINE | 5-METHYLCYTOSINE | DNA | MULTIDISCIPLINARY SCIENCES | HUMAN-LEUKEMIC CELLS | 5-HYDROXYMETHYLCYTOSINE | MONOPHOSPHATE KINASE | EXPRESSION | 5-FORMYLCYTOSINE | Neoplasms - metabolism | Phosphotransferases - metabolism | Cytosine - analogs & derivatives | Up-Regulation | Epigenesis, Genetic | Humans | Uridine - analogs & derivatives | Gene Expression Regulation, Neoplastic | Cytidine - pharmacology | Substrate Specificity | Deoxycytidine - pharmacology | Cytidine - analogs & derivatives | Nucleotides - chemistry | Deoxycytidine - metabolism | Neoplasms - genetics | Cytosine - metabolism | Nucleotides - pharmacology | DNA - biosynthesis | Cytosine - pharmacology | Cell Death - drug effects | Uridine - chemistry | DNA Damage - drug effects | Cytidine - chemistry | Oxidation-Reduction | Cytidine Deaminase - genetics | Cytosine - chemistry | Nucleotides - metabolism | Neoplasms - drug therapy | Gene Expression Regulation, Enzymologic | DNA - chemistry | Animals | 5-Methylcytosine - metabolism | 5-Methylcytosine - pharmacology | Cytidine Deaminase - metabolism | Cell Line, Tumor | Cytidine - metabolism | Uridine - metabolism | Mice | DNA-Directed DNA Polymerase - metabolism | Deoxycytidine - analogs & derivatives | Enzymes | Epigenetic inheritance | Care and treatment | Nucleosides | Genetic aspects | Metabolism | Health aspects | Methods | Cancer | DNA polymerase | Epigenetics | Cytotoxicity | Kinases | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus
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13. Full Text MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
by Mellén, Marian and Ayata, Pinar and Dewell, Scott and Kriaucionis, Skirmantas and Heintz, Nathaniel
Cell, ISSN 0092-8674, 12/2012, Volume 151, Issue 7, pp. 1417 - 1430
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the CNS may differ from those... 
RETT-SYNDROME | DNA METHYLATION | 5-METHYLCYTOSINE | TRANSLATIONAL PROFILING APPROACH | BASE-RESOLUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | HISTONE H1 | 5-HYDROXYMETHYLCYTOSINE | CPG SEQUENCES | BRAIN | CELL BIOLOGY | Chromatin - metabolism | Cytosine - analogs & derivatives | Purkinje Cells - metabolism | 5-Methylcytosine - analogs & derivatives | Cerebellum - metabolism | Epigenesis, Genetic | Humans | Methyl-CpG-Binding Protein 2 - metabolism | Mice, Knockout | Rett Syndrome - metabolism | Animals | Cytosine - metabolism | Cerebellum - cytology | Neuroglia - metabolism | Mice | Neurons - metabolism | Chromatin | Analysis | Oncology, Experimental | Genes | Genomics | Genetic research | Research | Gene expression | Embryonic stem cells | Cancer | Index Medicus
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