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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 02/2013, Volume 152, Issue 5, pp. 1146 - 1159
Journal Article
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 606 - 612
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2166 - 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
DNA METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | RETINOIC ACID RECEPTORS | ACUTE MYELOID-LEUKEMIA | MUTATIONS | 5-CARBOXYLCYTOSINE | DISCOVERY | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7403, pp. 415 - 419
Journal Article
Cancer Research, ISSN 0008-5472, 12/2011, Volume 71, Issue 24, pp. 7360 - 7365
Journal Article
DNA Repair, ISSN 1568-7864, 07/2016, Volume 43, pp. 78 - 88
The family of Ten-Eleven Translocation (TET) proteins is implicated in the process of active DNA demethylation and thus in epigenetic regulation. TET 1, 2 and... 
TET2 | Genetic instability | 5-hmC | TDG | Cell cycle | 5-METHYLCYTOSINE | CONVERSION | ACUTE MYELOID-LEUKEMIA | TET PROTEINS | MLL | THYMINE DNA GLYCOSYLASE | DEMETHYLATION | GENETICS & HEREDITY | TOXICOLOGY | 5-FORMYLCYTOSINE | 5-CARBOXYLCYTOSINE | Cytosine - analogs & derivatives | Genomic Instability | 5-Methylcytosine - analogs & derivatives | Epigenesis, Genetic | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Cytosine - metabolism | Base Sequence | S Phase | Thymine DNA Glycosylase - genetics | B-Lymphocytes - metabolism | Megakaryocyte Progenitor Cells - cytology | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | B-Lymphocytes - cytology | Hydroxylation | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Megakaryocyte Progenitor Cells - metabolism | Animals | 5-Methylcytosine - metabolism | Mutagenesis | DNA Repair | Thymine DNA Glycosylase - deficiency | Fibroblasts - cytology | Mice | Index Medicus | Megakaryocyte Progenitor Cells/metabolism | Thymine DNA Glycosylase/genetics | Proto-Oncogene Proteins/genetics | Cytosine/metabolism | B-Lymphocytes/metabolism | Genomics | Cytosine/analogs & derivatives | Tumor Suppressor Protein p53/metabolism | DNA-Binding Proteins/metabolism | B-Lymphocytes/cytology | Life Sciences | Thymine DNA Glycosylase/deficiency | Fibroblasts/metabolism | Fibroblasts/cytology | Biochemistry, Molecular Biology | 5-Methylcytosine/metabolism | Proto-Oncogene Proteins/metabolism | Tumor Suppressor Protein p53/genetics | Megakaryocyte Progenitor Cells/cytology | 5-Methylcytosine/analogs & derivatives | DNA-Binding Proteins/genetics
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7715, pp. 637 - 641
Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood glucose levels and frequently associated with life-threatening... 
METFORMIN | DNA METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | HYDROXYLATION | TRANSCRIPTION | 5-HYDROXYMETHYLCYTOSINE | COMPLICATIONS | Glycated Hemoglobin A - analysis | Neoplasms - metabolism | Phosphorylation | Metformin - therapeutic use | Diabetes Mellitus - genetics | 5-Methylcytosine - analogs & derivatives | Epigenesis, Genetic | Humans | Substrate Specificity | Proto-Oncogene Proteins - chemistry | DNA-Binding Proteins - metabolism | DNA Methylation | Neoplasms - genetics | Adenylate Kinase - metabolism | Proto-Oncogene Proteins - metabolism | Metformin - pharmacology | Enzyme Stability | Diabetes Mellitus - metabolism | DNA - metabolism | Phosphoserine - metabolism | DNA-Binding Proteins - chemistry | Neoplasms - drug therapy | Hyperglycemia - metabolism | Xenograft Model Antitumor Assays | DNA - chemistry | Animals | 5-Methylcytosine - metabolism | Mice, Nude | Glucose - metabolism | Mice | Epigenetic inheritance | Analysis | Diabetes | Methylation | Health aspects | Risk factors | Cancer | Ontology | Serine | Genomes | Glucose | Kinases | Metabolic syndrome | Epidemiology | Proteins | Metabolites | Cell cycle | DNA methylation | Deoxyribonucleic acid--DNA | Phenotypes | Stability | Diabetes mellitus | Health risks | Gene expression | Substrates | Stem cells | Epigenetics | Metformin | Destabilization | Metabolic disorders | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7569, pp. 389 - 393
Journal Article