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Biochemical Journal, ISSN 0264-6021, 03/2015, Volume 466, Issue 2, pp. 359 - 367
NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4K gamma) inhibitor, was explored as a tool for investigating this... 
Phosphatidylinositol 5-phosphate (pi5p) | Phosphatidylinositol 5-phosphate 4-kinase (pi5p4k) | Phosphatidylinositol 5-phosphate 4-kinase γ (pi5p4kγ) | PHOSPHATE KINASE | CELLS | phosphatidylinositol 5-phosphate (PI5P) | ACTIVATION | P110-ALPHA | phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM | phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4K gamma) | KINASE II-GAMMA | BETA | NUCLEAR-LOCALIZATION | VASOPRESSIN | EXPRESSION | Kidney Cortex - drug effects | Phosphatidylinositol Phosphates - metabolism | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Kidney Cortex - metabolism | Phosphatidylinositol Phosphates - antagonists & inhibitors | Protein Transport - drug effects | Deuterium Exchange Measurement | RNA Interference | Isoenzymes - metabolism | Cell Membrane - metabolism | Cell Polarity - drug effects | Binding Sites | Mutant Proteins - antagonists & inhibitors | Cell Membrane - drug effects | Recombinant Proteins - metabolism | Cell Line | Kidney Cortex - cytology | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Mutant Proteins - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Cell Differentiation - drug effects | Mutant Proteins - chemistry | Protein Conformation | Mice | Quinazolines - pharmacology | Kidney Cortex - enzymology | Isoenzymes - antagonists & inhibitors | Amino Acid Substitution | Index Medicus | WT, wild-type | TCEP, tris carboxyl ethyl phosphine | HDX, hydrogen–deuterium exchange | TBP, TATA-box-binding protein | phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) | HDX-MS, hydrogen-deuterium exchange mass spectrometry | mpkCCD, mouse principal kidney cortical collecting duct | PI5P, phosphatidylinositol 5-phosphate | UPLC, ultra performance liquid chromatography | QT-PCR, quantitative PCR
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 279 - 285
Trypanosoma cruzi, the human parasite that causes Chagas disease, contains a functional pentose phosphate pathway, probably essential for protection against... 
Chagas disease | Pentose phosphate pathway | Reaction mechanism | Type B ribose 5-phosphate isomerase (RpiB) | Ribose 5-phosphate isomerase (Rpi) | Trypanosoma cruzi | CATABOLISM | PENTOSE-PHOSPHATE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALDOSE-KETOSE ISOMERIZATION | ribose 5-phosphate isomerase (Rpi) | pentose phosphate pathway | type B ribose 5-phosphate isomerase (RpiB) | ANGSTROM RESOLUTION | TUBERCULOSIS RIBOSE-5-PHOSPHATE ISOMERASE | XYLOSE ISOMERASE | reaction mechanism | ENZYMES | ESCHERICHIA-COLI K-12 | PURIFICATION | EXPRESSION | Recombinant Proteins - metabolism | Amino Acid Sequence | Mutagenesis, Site-Directed | Molecular Sequence Data | Trypanosoma cruzi - enzymology | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Protozoan Proteins - metabolism | Cloning, Molecular | Conserved Sequence | Aldose-Ketose Isomerases - genetics | Kinetics | Aldose-Ketose Isomerases - metabolism | Index Medicus | TBS, tris-buffered saline | MtRpiB, Mycobacterium tuberculosis ribose 5-phosphate isomerase B | TcRpiB, Trypanosoma cruzi ribose 5-phosphate isomerase B | 4PEH, 4-phospho-D-erythronohydroxamic acid | R5P, ribose 5-phosphate | Rpi, ribose 5-phosphate isomerase | 4PEA, 4-phospho-D-erythronate | 4PEHz, 4-phospho-D-erythronhydrazide | MESNA, sodium 2-mercapto-ethanesulfonate | Ru5P, ribulose 5-phosphate | PPP, pentose phosphate pathway | EcRpiB, Escherichia coli ribose 5-phosphate isomerase B | 5PRH, 5-phospho-D-ribonohydroxamic acid | 4PEAm, 4-phospho-D-erythronamide
Journal Article
ACS Catalysis, ISSN 2155-5435, 03/2016, Volume 6, Issue 3, pp. 1649 - 1654
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2005, Volume 386, Issue 1, pp. 127 - 135
Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasniodium falciparum.... 
Malaria | Antibacterial drug | 2-C-methyl-D-erythritol 4-phosphate | Isoprenoid biosynthesis | 1-deoxy-D-xylulose 5-phosphate | 1-deoxy-D-xylulose 5-phosphate reducto-isomerase | isoprenoid biosynthesis | VIVO ANTIMALARIAL ACTIVITY | 1-deoxy-D-Xylulose 5-phosphate reducto-isomerase | ESTER PRODRUGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ESCHERICHIA-COLI | TERPENOID BIOSYNTHESIS | malaria | antibacterial drug | REACTION-INTERMEDIATE ANALOGS | HIGHER-PLANTS | HISTONE DEACETYLASE | NONMEVALONATE PATHWAY | Oxidoreductases - antagonists & inhibitors | Butyrates - pharmacology | Escherichia coli - drug effects | Enzyme Inhibitors - chemical synthesis | Microbial Sensitivity Tests | Organophosphonates - chemical synthesis | Terpenes - metabolism | Drug Resistance, Multiple, Bacterial | Drug Design | Escherichia coli Proteins - antagonists & inhibitors | NADP - metabolism | Hydroxamic Acids - pharmacology | Antimalarials - chemical synthesis | Fosfomycin - analogs & derivatives | Escherichia coli - enzymology | Fosfomycin - pharmacology | Enzyme Inhibitors - pharmacology | Multienzyme Complexes - antagonists & inhibitors | Antimalarials - pharmacology | Butyrates - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Organophosphonates - pharmacology | Anti-Bacterial Agents - pharmacology | Aldose-Ketose Isomerases - antagonists & inhibitors | Hydroxamic Acids - chemical synthesis | Index Medicus | H-DXR, His6-tagged DXR | THF, tetrahydrofuran | MEP, 2-C-methyl-D-erythritol 4-phosphate | HRMS, high-resolution MS | LB, Luria–Bertani | FAB, fast atom bombardment | DTT, dithiothreitol | DXR, 1-deoxy-D-xylulose 5-phosphate reducto-isomerase | DXP, 1-deoxy-D-xylulose 5-phosphate
Journal Article
FEBS Letters, ISSN 0014-5793, 2000, Volume 481, Issue 3, pp. 221 - 226
The present work aimed to proof the functionality of the non‐mevalonate pathway in cyanobacteria. It was intended to isolate the 1‐deoxy‐ D ‐xylulose... 
1-Deoxy- D-xylulose 5-phosphate | 1-Deoxy- D-xylulose 5-phosphate synthase gene | 1-Deoxy- D-xylulose 5-phosphate reductoisomerase gene | Isoprenoid biosynthesis | dxs | dxr | xylulose 5-phosphate synthase gene | 1-Deoxy | xylulose 5-phosphate | xylulose 5-phosphate reductoisomerase gene | 1-Deoxy-D-xylulose 5-phosphate synthase gene | 1-Deoxy-D-xylulose 5-phosphate reductoisomerase gene | 1-Deoxy-D-xylulose 5- phosphate | isoprenoid biosynthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TERPENOID BIOSYNTHESIS | CELL BIOLOGY | 1-deoxy-D-xylulose 5-phosphate synthase gene | SYNTHASE | BIOPHYSICS | PYRIDOXOL | CLONING | 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene | ISOPENTENYL DIPHOSPHATE | HETEROLOGOUS EXPRESSION | MEVALONATE-INDEPENDENT PATHWAY | 1-deoxy-D-xylulose 5-phosphate | NONMEVALONATE PATHWAY | Cyanobacteria - genetics | Aldose-Ketose Isomerases - isolation & purification | Erythritol - analogs & derivatives | Bacterial Proteins - chemistry | Organophosphorus Compounds - metabolism | Oxidoreductases - chemistry | Transferases - genetics | Oxidoreductases - isolation & purification | Transferases - metabolism | Erythritol - metabolism | Hydro-Lyases - genetics | Hydro-Lyases - biosynthesis | Oxidoreductases - biosynthesis | Recombinant Fusion Proteins - biosynthesis | Genes, Bacterial | Aldose-Ketose Isomerases - chemistry | Gene Library | Oxidoreductases - genetics | Bacterial Proteins - genetics | Recombinant Fusion Proteins - chemical synthesis | Transferases - isolation & purification | Cyanobacteria - enzymology | Multienzyme Complexes - genetics | Genetic Markers | Recombinant Fusion Proteins - chemistry | Open Reading Frames - genetics | Operon - genetics | Cosmids - isolation & purification | Polyisoprenyl Phosphates - metabolism | Sequence Analysis, DNA | Oligonucleotide Probes - metabolism | Multienzyme Complexes - chemistry | Sequence Homology, Amino Acid | Gene Amplification | Sugar Phosphates - metabolism | Hemiterpenes | Multienzyme Complexes - biosynthesis | Aldose-Ketose Isomerases - genetics | Hydro-Lyases - chemistry | Multienzyme Complexes - isolation & purification | Aldose-Ketose Isomerases - biosynthesis | Index Medicus
Journal Article
ISSN 0027-8424, 2016
Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are enigmatic lipid kinases whose physiological functions are incompletely understood, not least because... 
mTOR | Phosphatidylinositol 5-phosphate 4-kinase | Akt | Phosphatidylinositol 5-phosphate | Phosphatidylinositol (4,5) bisphosphate | protein kinase B
Journal Article
FEBS Journal, ISSN 1742-464X, 11/2013, Volume 280, Issue 22, pp. 5896 - 5905
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 17, pp. 2806 - 2817
The methylerythritol phosphate (MEP) pathway of ( ) has become an attractive target for anti-malarial drug discovery. This study describes a kinetic model of... 
Drug target | Kinetic model | Malaria | Metabolic control analysis | Methylerythritol phosphate (MEP) | xylulose 5-phosphate synthase | flux control coefficient | HMBPP | IPP | SBML | erythritol synthase | MECPPS | BLAST | Isopentenyl pyrophosphate | FCC | butenyl 4-diphosphate synthase | basic local alignment search tool | erythritol kinase | MECPP | CDPME | GAP | erythritol 2,4-cyclodiphosphate synthase | MEP | DMAPP | xylulose 5-phosphate | DXP | DXS | methylerythritol phosphate | DXR | glyceraldehyde 3-phosphate | 4-(cytidine 5′-diphospho)-2 | PDB | concentration control coefficient | xylulose 5-phosphate reductoisomerase | protein data bank | methyl | 2-phospho-4-(cytidine 5′-diphospho)-2 | BLAST-P | dimethylallyl diphosphate | CCC | butenyl 4-diphosphate reductase | PYR | PSI-BLAST | HMBPPR | pyruvate | HMBPPS | system biology markup language | CDPMEP | protein BLAST | CDPMES | butenyl 4-diphosphate | erythritol 2,4-cyclodiphosphate | position-specific iterated BLAST | CDPMEK | 1-hydroxy-2-methyl-2- | erythritol | 1-deoxy | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE | CELL BIOLOGY | STEADY-STATE TREATMENT | SUBSTRATE-BINDING | BIOPHYSICS | BIOSYNTHESIS | PLANTS | SYSTEMS BIOLOGY | Enzymes - chemistry | Oxidoreductases - antagonists & inhibitors | Plasmodium falciparum - enzymology | Erythritol - analogs & derivatives | Models, Chemical | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Oxidoreductases - chemistry | Terpenes - metabolism | Computer Simulation | Enzyme Inhibitors - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Erythritol - metabolism | Phosphorus-Oxygen Lyases - chemistry | Transferases - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Aldose-Ketose Isomerases - chemistry | Escherichia coli - enzymology | Transferases - chemistry | Biosynthetic Pathways | Multienzyme Complexes - antagonists & inhibitors | Multienzyme Complexes - chemistry | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Algorithms | Models, Biological | Kinetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Escherichia coli Proteins - chemistry | Phosphorus-Oxygen Lyases - antagonists & inhibitors | Phosphates | Plasmodium falciparum | Enzymes | Metabolites | Analysis | Phytochemistry | Physiological aspects | Models | Sugars | Monosaccharides | Index Medicus
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 05/2019, Volume 17, Issue 17, pp. 4350 - 4358
Pyridoxal 5'-phosphate (PLP) is a versatile cofactor involved in a large variety of enzymatic processes. Most of PLP-catalysed reactions, such as those of... 
MOLECULAR-DYNAMICS | INHIBITION | INTEGRATION | AMINOTRANSFERASE | ENZYMES | CHEMISTRY, ORGANIC | PYRIDOXAL 5-PHOSPHATE
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 09/2016, Volume 113, Issue 38, pp. 10571 - 10576
Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are enigmatic lipid kinases with physiological functions that are incompletely understood, not the least... 
MEMBRANE | MULTIDISCIPLINARY SCIENCES | ALPHA-GRANULE SECRETION | DEPLETION | ISOFORM | Akt | II-ALPHA | BETA | phosphatidylinositol 5-phosphate 4-kinase | NUCLEAR-LOCALIZATION | phosphatidylinositol (4,5)-bisphosphate | GROWTH | mTOR | phosphatidylinositol 5-phosphate | REVEALS | KINASES
Journal Article
Journal Article