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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Prostate cancer resistance to castration occurs because tumours acquire the metabolic capability of converting precursor steroids to 5... 
ANDROGEN RECEPTOR | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | CYP17A1 INHIBITION | MECHANISM | TESTOSTERONE | RATIONALE | MULTIDISCIPLINARY SCIENCES | INCREASED SURVIVAL | CHEMOTHERAPY | EXPOSURE | ENZALUTAMIDE | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2011, Volume 39, Issue 5, pp. 847 - 857
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 1992, Volume 183, Issue 3, pp. 1254 - 1259
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 02/2012, Volume 212, Issue 2, pp. 111 - 127
5α-Reduced glucocorticoids (GCs) are formed when one of the two isozymes of 5α-reductase reduces the Δ(4-5) double bond in the A-ring of GCs. These steroids... 
5-alpha Reductase Inhibitors - chemistry | Glucocorticoids - therapeutic use | Receptors, Glucocorticoid - antagonists & inhibitors | Corticosterone - pharmacology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - chemistry | Humans | Hydrocortisone - metabolism | Hydrocortisone - therapeutic use | Isoenzymes - chemistry | Receptors, Glucocorticoid - metabolism | Anti-Inflammatory Agents - metabolism | Hydrocortisone - analogs & derivatives | Receptors, Glucocorticoid - agonists | Inflammation - metabolism | Liver - immunology | Liver - drug effects | Glucocorticoids - metabolism | Inflammation - drug therapy | Isoenzymes - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Corticosterone - analogs & derivatives | Anti-Inflammatory Agents - therapeutic use | Biomarkers - metabolism | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Isoenzymes - genetics | Liver - metabolism | Selection, Genetic | 5-alpha Reductase Inhibitors - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 5-alpha Reductase Inhibitors - pharmacology | Glucocorticoids - chemistry | Glucocorticoids - pharmacology | Corticosterone - metabolism | Hydrocortisone - pharmacology | 5-alpha Reductase Inhibitors - metabolism | Corticosterone - therapeutic use | Index Medicus
Journal Article
Journal Article
Reproduction, ISSN 1470-1626, 2018, Volume 155, Issue 3, pp. 251 - 258
In the latter half of gestation in the mare, progesterone concentrations decline to near undetectable levels while other 5 alpha-reduced pregnanes are... 
REPRODUCTIVE BIOLOGY | PROGESTERONE | BLOOD-PLASMA | COWS | DEVELOPMENTAL BIOLOGY | FETAL | PARTURITION | EQUINE | RETAINED PLACENTA | MASS-SPECTROMETRY | 5-ALPHA-DIHYDROPROGESTERONE | DUTASTERIDE | Index Medicus
Journal Article
DIABETES, ISSN 0012-1797, 02/2015, Volume 64, Issue 2, pp. 447 - 458
5 alpha-Reductase type 1 (5 alpha R1) catalyses A-ring reduction of androgens and glucocorticoids in liver, potentially influencing hepatic manifestations of... 
POLYCYSTIC-OVARY-SYNDROME | ANDROGEN RECEPTOR | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | OBESE ZUCKER RATS | TISSUE DISTRIBUTION | ENDOCRINOLOGY & METABOLISM | MALE-MICE | BODY-FAT DISTRIBUTION | STEROID 5-ALPHA-REDUCTASE | CORTISOL METABOLISM | ADIPOSE-TISSUE
Journal Article