Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (4725) 4725
Publication (306) 306
Conference Proceeding (80) 80
Book Review (35) 35
Dissertation (33) 33
Book Chapter (31) 31
Magazine Article (3) 3
Web Resource (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
5-aminolevulinic acid (4295) 4295
humans (2243) 2243
photodynamic therapy (1961) 1961
index medicus (1849) 1849
cancer (1077) 1077
female (1060) 1060
photochemotherapy (1022) 1022
fluorescence (1010) 1010
male (996) 996
animals (923) 923
surgery (832) 832
oncology (720) 720
photochemotherapy - methods (666) 666
middle aged (654) 654
dermatology (640) 640
aminolevulinic acid (591) 591
aged (571) 571
biochemistry & molecular biology (563) 563
photosensitizing agents - therapeutic use (558) 558
adult (529) 529
protoporphyrin ix (506) 506
aminolevulinic acid - therapeutic use (464) 464
treatment outcome (445) 445
mice (425) 425
tumors (422) 422
light (414) 414
delta-aminolevulinic-acid (411) 411
aminolevulinic acid - administration & dosage (398) 398
aminolevulinic acid - pharmacology (395) 395
care and treatment (385) 385
photosensitizing agents - administration & dosage (385) 385
in-vitro (377) 377
protoporphyrin-ix (364) 364
skin (355) 355
biophysics (348) 348
in-vivo (318) 318
clinical neurology (312) 312
photosensitizing agents - pharmacology (312) 312
diagnosis (300) 300
cell line, tumor (285) 285
aged, 80 and over (279) 279
porphyrins (273) 273
pharmacology & pharmacy (267) 267
aminolevulinic acid - analogs & derivatives (262) 262
rats (249) 249
analysis (247) 247
resection (234) 234
skin neoplasms - drug therapy (234) 234
protoporphyrins - metabolism (233) 233
glioblastoma-multiforme (231) 231
malignant glioma (226) 226
ala (220) 220
carcinoma (218) 218
apoptosis (217) 217
research (215) 215
brain neoplasms - surgery (213) 213
photodynamic diagnosis (211) 211
medicine & public health (210) 210
therapy (210) 210
cells (208) 208
topical 5-aminolevulinic acid (206) 206
basal-cell carcinoma (202) 202
glioma (201) 201
bladder cancer (199) 199
health aspects (195) 195
induced protoporphyrin-ix (193) 193
photochemotherapy - adverse effects (193) 193
aminolevulinic acid - metabolism (185) 185
protoporphyrin (185) 185
internal medicine (184) 184
hematology, oncology and palliative medicine (183) 183
plant sciences (183) 183
administration, topical (179) 179
urology & nephrology (177) 177
glioblastoma (176) 176
aminolevulinic-acid (172) 172
sensitivity and specificity (172) 172
biosynthesis (171) 171
photosensitizing agents (167) 167
article (166) 166
gliomas (166) 166
lasers (166) 166
photosensitization (166) 166
pdt (163) 163
time factors (160) 160
chemistry, multidisciplinary (159) 159
survival (157) 157
usage (155) 155
expression (154) 154
actinic keratosis (153) 153
oxidative stress (153) 153
photosensitizer (152) 152
skin cancer (152) 152
enzymes (151) 151
brain neoplasms - pathology (148) 148
dose-response relationship, drug (148) 148
endogenous protoporphyrin (148) 148
radiology, nuclear medicine & medical imaging (148) 148
neurosurgery (147) 147
gastroenterology & hepatology (146) 146
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (4559) 4559
German (82) 82
Japanese (40) 40
Korean (30) 30
Chinese (24) 24
French (24) 24
Russian (18) 18
Spanish (18) 18
Portuguese (15) 15
Polish (11) 11
Czech (10) 10
Lithuanian (3) 3
Dutch (2) 2
Slovak (2) 2
Turkish (2) 2
Bulgarian (1) 1
Croatian (1) 1
Hungarian (1) 1
Italian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Intraoperative tissue fluorescence using 5-aminolevolinic acid (5-ALA) is more sensitive than contrast MRI or amino acid positron emission tomography (18F-FET PET) in glioblastoma surgery
by Roessler, Karl and Becherer, Alexander and Donat, Markus and Cejna, Manfred and Zachenhofer, Iris
Neurological Research, ISSN 0161-6412, 04/2012, Volume 34, Issue 3, pp. 314 - 317
Objective: The sensitivity of 5-aminolevolinic acid (5-ALA) in detecting intraoperative glioblastoma (GBM) tissue compared to postoperative 18... 
Correlation | 5-aminolevolinic acid | Resection guidance | FET PET | Glioblastoma | SURVIVAL | GLIOMA SURGERY | RESECTION | HISTOPATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | BRAIN-TUMORS | GD-DTPA | DELINEATION | EXTENT | 5-AMINOLEVULINIC ACID
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text δ‐Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
by Frølund, S and Marquez, OC and Larsen, M and Brodin, B and Nielsen, CU
British Journal of Pharmacology, ISSN 0007-1188, 03/2010, Volume 159, Issue 6, pp. 1339 - 1353
Background and purpose:  δ‐Aminolevulinic acid (ALA) is used in cancer patients for photodynamic diagnosis or therapy. Oral administration of ALA has been used... 
δ‐aminolevulinic acid | hPEPT1 (SLC15A1) | Gly‐Sar | intestinal absorption | drug delivery | hPAT1 (SLC36A1) | Drug delivery | Intestinal absorption | δ-aminolevulinic acid | Gly-Sar | BLADDER-CANCER | DIPEPTIDE TRANSPORT | delta-aminolevulinic acid | H+/PEPTIDE SYMPORTER PEPT1 | ACTIVE-TRANSPORT | THERAPEUTIC APPLICATIONS | EPIDERMAL-GROWTH-FACTOR | 5-AMINOLEVULINIC ACID | CACO-2 CELL MONOLAYERS | PHARMACOLOGY & PHARMACY | BRUSH-BORDER MEMBRANE | OLIGOPEPTIDE TRANSPORTER | Caco-2 Cells | Membrane Potentials - drug effects | Peptide Transporter 1 | Humans | Oligopeptides - pharmacokinetics | Aminolevulinic Acid - pharmacology | Cercopithecus aethiops | Substrate Specificity | Intestines - metabolism | Amino Acid Transport Systems - metabolism | Intestinal Absorption | Symporters - metabolism | Dose-Response Relationship, Drug | Aminolevulinic Acid - pharmacokinetics | Photosensitizing Agents - pharmacology | Animals | Transfection | Biological Transport | Photosensitizing Agents - pharmacokinetics | Oligopeptides - pharmacology | COS Cells | Research Papers
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text 5-Aminolevulinic Acid-derived Tumor Fluorescence: The Diagnostic Accuracy of Visible Fluorescence Qualities as Corroborated by Spectrometry and Histology and Postoperative Imaging
by Stummer, Walter and Tonn, Jörg-Christian and Goetz, Claudia and Ullrich, Winfried and Stepp, Herbert and Bink, Andrea and Pietsch, Thorsten and Pichlmeier, Uwe
Neurosurgery, ISSN 0148-396X, 03/2014, Volume 74, Issue 3, pp. 310 - 320
BACKGROUND:5-Aminolevulinic acid is used for fluorescence-guided resections. During resection, different macroscopic fluorescence qualities (“strong,” “weak”)... 
5-Aminolevulinic acid | Malignant glioma | Sensitivity | Specificity | Spectrometry | Fluorescence-guided resection | SURGERY | SURVIVAL | PROTOPORPHYRIN-IX-FLUORESCENCE | GLIOBLASTOMA-MULTIFORME | TISSUE | CLINICAL NEUROLOGY | INTRAOPERATIVE DETECTION | MALIGNANT GLIOMAS | OPTICAL SPECTROSCOPY | GUIDED RESECTION | GROSS TOTAL RESECTION | Prospective Studies | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Middle Aged | Male | Treatment Outcome | Biometry | Young Adult | Photosensitizing Agents | Spectrum Analysis - methods | Adolescent | Brain Neoplasms - therapy | Adult | Female | Aged | Glioma - surgery | Aminolevulinic Acid | Research—Human—Clinical Trials
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Preclinical characterization of 5-amino-4-oxo-[6-11C] hexanoic acid as an imaging probe to estimate protoporphyrin IX accumulation induced by exogenous aminolevulinic acid
by Suzuki, Chie and Tsuji, Atsushi B and Kato, Koichi and Kikuchi, Tatsuya and Sudo, Hitomi and Okada, Maki and Sugyo, Aya and Zhang, Ming-Rong and Arano, Yasushi and Saga, Tsuneo
Journal of Nuclear Medicine, ISSN 0161-5505, 10/2014, Volume 55, Issue 10, pp. 1671 - 1677
Preoperative noninvasive imaging to estimate the quantity and spatial distribution of protoporphyrin IX (PpIX) accumulation in tumors induced by... 
C-MALA | Photodynamic therapy | 5-aminolevulinic acid | Sonodynamic therapy | Aminolevulinic acid dehydratase | BLADDER-CANCER | CELLS | photodynamic therapy | C-11-MALA | GLIOMA | aminolevulinic acid dehydratase | sonodynamic therapy | IN-VITRO | FLUORESCENCE | ONCOLOGY | ALA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | EXPOSURE | Neoplasm Transplantation | Aminolevulinic Acid - chemistry | Animals | Humans | Cell Line, Tumor | Mice | Aminocaproates - chemistry | Positron-Emission Tomography - methods | Protoporphyrins - chemistry | Neoplasms - diagnostic imaging | Aminocaproates - pharmacokinetics | Neoplasms - drug therapy
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Homology Modeling of Human γ-Butyric Acid Transporters and the Binding of Pro-Drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid Used in Photodynamic Therapy
by Baglo, Yan and Gabrielsen, Mari and Sylte, Ingebrigt and Gederaas, Odrun A
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65200
Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA... 
NEUROTRANSMITTER | SYSTEM | MECHANISM | PROTOPORPHYRIN-IX | CLONING | MULTIDISCIPLINARY SCIENCES | GABA TRANSPORTER | CLASSIFICATION | LEUT | IDENTIFICATION | INHIBITOR | Aminolevulinic Acid - chemistry | gamma-Aminobutyric Acid - metabolism | Humans | gamma-Aminobutyric Acid - chemistry | Models, Molecular | Prodrugs - chemistry | Static Electricity | Photochemotherapy | Prodrugs - metabolism | Aminolevulinic Acid - metabolism | Aminolevulinic Acid - analogs & derivatives | Protein Binding | Molecular Docking Simulation | Structural Homology, Protein | Binding Sites | GABA Plasma Membrane Transport Proteins - chemistry | Drugs | Health sciences | Reactive oxygen species | Amino acids | Homology | Esters | Leucine | Aminolevulinic acid | Cancer therapies | Molecular docking | Butyric acid | Skin cancer | Proteins | γ-Aminobutyric acid | Toxicology | Pain | Protoporphyrin | Crystal structure | Nerve endings | Translocation | Medical research | Photodynamic therapy | Light effects | Substrates | Medicine | Studies | Side effects | Inhibitors | Acids | Skin | Protoporphyrin IX | Transporter | Binding sites | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Counterbalancing risks and gains from extended resections in malignant glioma surgery: A supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study: Clinical article
by Stummer, Walter and Tonn, Jörg-Christian and Mehdorn, Hubertus Maximilian and Nestler, Ulf and Franz, Kea and Goetz, Claudia and Bink, Andrea and Pichlmeier, Uwe and Ala-Glioma Study Grp and ALA-Glioma Study Group
Journal of Neurosurgery, ISSN 0022-3085, 03/2011, Volume 114, Issue 3, pp. 613 - 623
Object. Accumulating data suggest more aggressive surgery in patients with malignant glioma to improve outcome. However, extended surgery may increase... 
Malignant glioma | Resection | 5-aminolevulinic acid | Surgical risk | SURVIVAL | SURGERY | surgical risk | GLIOBLASTOMA-MULTIFORME | PROGNOSIS | PHASE-II | RELIABILITY | NIH STROKE SCALE | malignant glioma | resection | CLINICAL NEUROLOGY | TEMOZOLOMIDE | TRIAL | 1ST | Postoperative Complications - etiology | Humans | Middle Aged | Fluorescence | Male | Consciousness Disorders | Brain Neoplasms - surgery | Young Adult | Nervous System Diseases - epidemiology | Karnofsky Performance Status | Endpoint Determination | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Glioma - surgery | Aminolevulinic Acid | Risk Assessment | Kaplan-Meier Estimate | Surgery, Computer-Assisted - methods | Treatment Outcome | Postoperative Complications - epidemiology | Preoperative Care | Magnetic Resonance Imaging | Dexamethasone - therapeutic use | Image Processing, Computer-Assisted | Photosensitizing Agents | Nervous System Diseases - etiology | Aged | Neurosurgical Procedures - methods
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Coregistered fluorescence-enhanced tumor resection of malignant glioma: Relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters: Clinical article
by Roberts, David W and Valdés, Pablo A and Harris, Brent T and Fontaine, Kathryn M and Hartov, Alexander and Fan, Xiaoyao and Ji, Songbai and Lollis, S. Scott and Pogue, Brian W and Leblond, Frederic and Tosteson, Tor D and Wilson, Brian C and Paulsen, Keith D
Journal of Neurosurgery, ISSN 0022-3085, 03/2011, Volume 114, Issue 3, pp. 595 - 603
Object. The aim of this study was to investigate the relationships between intraoperative fluorescence, features on MR imaging, and neuropathological... 
Malignant glioma | Protoporphyrin IX | Contrast enhancement | δ-aminolevulinic acid | Fluorescence-guided resection | SURGERY | SURVIVAL | SYSTEM | SODIUM | protoporphyrin IX | GLIOBLASTOMA-MULTIFORME | fluorescence-guided resection | delta-aminolevulinic acid | malignant glioma | CLINICAL NEUROLOGY | BRAIN-TUMORS | TECHNICAL NOTE | INTRAOPERATIVE DETECTION | 5-AMINOLEVULINIC ACID | GUIDED RESECTION | contrast enhancement | Data Interpretation, Statistical | Protoporphyrins | Humans | Middle Aged | Brain Neoplasms - pathology | Fluorescence | Male | Surgery, Computer-Assisted - methods | Brain Neoplasms - surgery | Paraffin Embedding | Magnetic Resonance Imaging | Image Processing, Computer-Assisted | Photosensitizing Agents | Biopsy | Glioma - pathology | Aged, 80 and over | Female | Aged | Neurosurgical Procedures - methods | Glioma - surgery | Aminolevulinic Acid | Microscopy, Fluorescence
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery
by Valdés, Pablo A and Valdés, Pablo A and Jacobs, Valerie and Jacobs, Valerie and Harris, Brent T and Harris, Brent T and Wilson, Brian C and Wilson, Brian C and Leblond, Frederic and Leblond, Frederic and Paulsen, Keith D and Paulsen, Keith D and Roberts, David W and Roberts, David W
Journal of neurosurgery, ISSN 0022-3085, 09/2015, Volume 123, Issue 3, pp. 771 - 780
OBJECT Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PplX) accumulates in higher concentrations in tumor tissue, and,... 
CPpIX = concentration of PpIX | protoporphyrin IX | AUC = area under the curve | ALA = 5-aminolevulinic acid | LGG = low-grade glioma | brain tumor | biomedical optics | oncology | fluorescence-guided surgery | HGG = high-grade glioma | low-grade glioma | PPV = positive predictive value | quantitative fluorescence | NPV = negative predictive value | ROC = receiver operating characteristic | optical spectroscopy | 5-aminolevulinic acid | PpIX = protoporphyrin IX | SURVIVAL | VISUALIZATION | SURGERY | GLIOBLASTOMA-MULTIFORME | PRINCIPLES | CLINICAL NEUROLOGY | BRAIN-TUMORS | MALIGNANT GLIOMA | SPECTROSCOPY | ALA | EXTENT | GUIDED RESECTION | Biomarkers - metabolism | Neuronavigation - methods | Humans | Middle Aged | Fluorescence | Male | Protoporphyrins - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Glioma - metabolism | Photosensitizing Agents | Adult | Female | Aged | Glioma - surgery | Aminolevulinic Acid
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text In vitro evaluation of 5-aminolevulinic acid (ALA) loaded PLGA nanoparticles
by Shi, Lei and Wang, Xiuli and Zhao, Feng and Luan, Hansen and Tu, Qingfeng and Huang, Zheng and Wang, Hao and Wang, Hongwei
International Journal of Nanomedicine, ISSN 1176-9114, 07/2013, Volume 8, Issue 1, pp. 2669 - 2676
Background: 5-Aminolevulinic acid (ALA) is a prodrug for topical photodynamic therapy. The effectiveness of topical ALA can be limited by its bioavailability.... 
Nanoparticles | Skin squamous cell carcinoma | 5-Aminolevulinic acid (ALA) | Poly(lactic-co-glycolic acid) (PLGA) | Photodynamic therapy (PDT) | poly(lactic-co-glycolic acid) (PLGA) | PHOTODYNAMIC THERAPY | DELTA-AMINOLEVULINIC-ACID | WORKERS | NANOSCIENCE & NANOTECHNOLOGY | CANCER | CELLULAR UPTAKE | DELIVERY | nanoparticles | skin squamous cell carcinoma | PLASMA | ESTERS | PHARMACOLOGY & PHARMACY | photodynamic therapy (PDT) | SKIN | NANOTECHNOLOGY | Aminolevulinic Acid - toxicity | Cell Survival - drug effects | Microscopy, Electron, Transmission | Aminolevulinic Acid - chemistry | Lactic Acid - chemistry | Photosensitizing Agents - chemistry | Nanoparticles - chemistry | Photochemotherapy - methods | Humans | Polyglycolic Acid - toxicity | Cell Survival - radiation effects | Nanoparticles - toxicity | Particle Size | Lactic Acid - pharmacokinetics | Aminolevulinic Acid - pharmacokinetics | Analysis of Variance | Polyglycolic Acid - pharmacokinetics | Photosensitizing Agents - toxicity | Polyglycolic Acid - chemistry | Cell Line, Tumor | Photosensitizing Agents - pharmacokinetics | Calorimetry, Differential Scanning | Lactic Acid - toxicity | Kinetics | Drugs | Drug delivery systems | Photosensitizing compounds | Research | Photochemotherapy | Health aspects | Vehicles | Cancer | Photodynamic therapy | Original Research
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Guidelines for topical photodynamic therapy: update
by Morton, C.A and McKenna, K.E and Rhodes, L.E and British Assoc Dermatologists Thera and British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group and on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group
British Journal of Dermatology, ISSN 0007-0963, 12/2008, Volume 159, Issue 6, pp. 1245 - 1266
Summary Multicentre randomized controlled studies now demonstrate high efficacy of topical photodynamic therapy (PDT) for actinic keratoses, Bowen's disease... 
5-aminolaevulinic acid | nonmelanoma skin cancer | guidelines | protoporphyrin IX | topical photodynamic therapy | methyl aminolaevulinate | 5‐aminolaevulinic acid | Methyl aminolaevulinate | Topical photodynamic therapy | Protoporphyrin IX | Nonmelanoma skin cancer | Guidelines | ALLERGIC CONTACT-DERMATITIS | RANDOMIZED-CONTROLLED-TRIAL | DELTA-AMINOLEVULINIC-ACID | VULVAL INTRAEPITHELIAL NEOPLASIA | PROTOPORPHYRIN-IX FLUORESCENCE | DERMATOLOGY | INTENSE PULSED-LIGHT | SUPERFICIAL ACTINIC POROKERATOSIS | BASAL-CELL CARCINOMA | ORGAN-TRANSPLANT RECIPIENTS | APPLIED 5-AMINOLEVULINIC ACID | Photochemotherapy - adverse effects | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Humans | Carcinoma, Basal Cell - drug therapy | Photosensitizing Agents - adverse effects | Skin Diseases - drug therapy | Administration, Topical | Practice Guidelines as Topic | Prevention | Squamous cell carcinoma | Care and treatment | Pain | Psoriasis | Oncology, Experimental | Melanoma | Research | Health aspects | Skin cancer | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications
by Nokes, Brandon, MS and Apel, Matt, MD and Jones, Carol, MD and Brown, Gabrielle, MS and Lang, Julie E., MD, FACS
Journal of Surgical Research, ISSN 0022-4804, 2013, Volume 181, Issue 2, pp. 262 - 271
Abstract Aminolevulinic acid (ALA) is a heme precursor that may have potential applications for photodynamic detection and photodynamic therapy–based treatment... 
Surgery | Fluorescence | Photodynamic | Aminolevulinic acid | ALA | Cancer | INDUCED PROTOPORPHYRIN-IX | SURGERY | HIGH-GRADE DYSPLASIA | SUPERFICIAL BLADDER-CANCER | GLIOBLASTOMA-MULTIFORME | CERVICAL INTRAEPITHELIAL NEOPLASIA | FLUORESCENCE-GUIDED RESECTION | IN-VITRO | 5-AMINOLEVULINIC ACID | PLACEBO-CONTROLLED TRIAL | DYSPLASTIC BARRETTS-ESOPHAGUS | Drug Administration Routes | Photosensitizing Agents - therapeutic use | Humans | Aminolevulinic Acid - therapeutic use | Antineoplastic Agents - therapeutic use | Drug Approval | Neoplasms - diagnosis | Photochemotherapy | Neoplasms - drug therapy | Health aspects | Universities and colleges
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights