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1. Full Text 5-Aminolevulinic Acid-derived Tumor Fluorescence: The Diagnostic Accuracy of Visible Fluorescence Qualities as Corroborated by Spectrometry and Histology and Postoperative Imaging
by Stummer, Walter and Tonn, Jörg-Christian and Goetz, Claudia and Ullrich, Winfried and Stepp, Herbert and Bink, Andrea and Pietsch, Thorsten and Pichlmeier, Uwe
Neurosurgery, ISSN 0148-396X, 03/2014, Volume 74, Issue 3, pp. 310 - 320
5-Aminolevulinic acid | Malignant glioma | Sensitivity | Specificity | Spectrometry | Fluorescence-guided resection | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Prospective Studies | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Middle Aged | Male | Treatment Outcome | Biometry | Young Adult | Photosensitizing Agents | Spectrum Analysis - methods | Adolescent | Brain Neoplasms - therapy | Adult | Female | Aged | Glioma - surgery | Aminolevulinic Acid | Magnetic resonance imaging | Scientific imaging | Neurosurgery | Index Medicus | Research—Human—Clinical Trials
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2. Full Text Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas: Clinical article
by Sanai, Nader and Snyder, Laura A and Honea, Norissa J and Coons, Stephen W and Eschbacher, Jennifer M and Smith, Kris A and Spetzler, Robert F
Journal of neurosurgery, ISSN 0022-3085, 10/2011, Volume 115, Issue 4, pp. 740 - 748
Tumor fluorescence | Extent of resection | Confocal microscopy | Oncology | 5-aminolevulinic acid | Low-grade glioma | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Biological and medical sciences | Medical sciences | Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases | Neurosurgery
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3. Full Text Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery
by Valdés, Pablo A and Valdés, Pablo A and Jacobs, Valerie and Jacobs, Valerie and Harris, Brent T and Harris, Brent T and Wilson, Brian C and Wilson, Brian C and Leblond, Frederic and Leblond, Frederic and Paulsen, Keith D and Paulsen, Keith D and Roberts, David W and Roberts, David W
Journal of neurosurgery, ISSN 0022-3085, 09/2015, Volume 123, Issue 3, pp. 771 - 780
CPpIX = concentration of PpIX | protoporphyrin IX | AUC = area under the curve | ALA = 5-aminolevulinic acid | LGG = low-grade glioma | brain tumor | biomedical optics | oncology | fluorescence-guided surgery | HGG = high-grade glioma | low-grade glioma | PPV = positive predictive value | quantitative fluorescence | NPV = negative predictive value | ROC = receiver operating characteristic | optical spectroscopy | 5-aminolevulinic acid | PpIX = protoporphyrin IX | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Biomarkers - metabolism | Neuronavigation - methods | Humans | Middle Aged | Fluorescence | Male | Protoporphyrins - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Glioma - metabolism | Photosensitizing Agents | Adult | Female | Aged | Glioma - surgery | Aminolevulinic Acid | Index Medicus | Abridged Index Medicus
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4. Full Text What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?
by Hadjipanayis, Costas G and Widhalm, Georg and Stummer, Walter
Neurosurgery, ISSN 0148-396X, 11/2015, Volume 77, Issue 5, pp. 663 - 673
5-Aminolevulinic acid | Glioma | Glioblastoma multiforme | Fluorescence-guided surgery | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Neuronavigation - methods | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Fluorescence | Magnetic Resonance Imaging - methods | Photosensitizing Agents - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Glioma - metabolism | Aminolevulinic Acid - metabolism | Monitoring, Intraoperative - methods | Glioma - surgery | Neurosurgery | Index Medicus
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5. Full Text Preclinical characterization of 5-amino-4-oxo-[6-11C] hexanoic acid as an imaging probe to estimate protoporphyrin IX accumulation induced by exogenous aminolevulinic acid
by Suzuki, Chie and Tsuji, Atsushi B and Kato, Koichi and Kikuchi, Tatsuya and Sudo, Hitomi and Okada, Maki and Sugyo, Aya and Zhang, Ming-Rong and Arano, Yasushi and Saga, Tsuneo
The Journal of nuclear medicine (1978), ISSN 0161-5505, 10/2014, Volume 55, Issue 10, pp. 1671 - 1677
C-MALA | Photodynamic therapy | 5-aminolevulinic acid | Sonodynamic therapy | Aminolevulinic acid dehydratase | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Neoplasm Transplantation | Aminolevulinic Acid - chemistry | Animals | Humans | Cell Line, Tumor | Mice | Aminocaproates - chemistry | Positron-Emission Tomography - methods | Protoporphyrins - chemistry | Neoplasms - diagnostic imaging | Aminocaproates - pharmacokinetics | Neoplasms - drug therapy | Nuclear medicine | Medical imaging | Rodents | Hemoglobin | Amino acids | Radiation therapy | Tumors | Index Medicus
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6. Full Text Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid–Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma
by Belykh, Evgenii and Miller, Eric J and Hu, Danying and Martirosyan, Nikolay L and Woolf, Eric C and Scheck, Adrienne C and Byvaltsev, Vadim A and Nakaji, Peter and Nelson, Leonard Y and Seibel, Eric J and Preul, Mark C
World neurosurgery, ISSN 1878-8750, 05/2018, Volume 113, pp. e51 - e69
5-Aminolevulinic acid | Glioma | Microscopy | Protoporphyrin IX | Fluorescence-guided surgery | Scanning fiber endoscope | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Neoplasm Transplantation | Neuroendoscopy - methods | Brain Neoplasms - diagnostic imaging | Brain Neoplasms - pathology | Fluorescent Dyes - analysis | Aminolevulinic Acid - administration & dosage | Microscopy, Fluorescence - instrumentation | Neoplasm Grading | Glioma - chemistry | Biotransformation | Glioma - pathology | Female | Photosensitizing Agents - analysis | Single-Cell Analysis | Genes, Reporter | Neuroendoscopes | Photobleaching | Brain Neoplasms - chemistry | Administration, Oral | Neoplasm Invasiveness | Mice, Inbred C57BL | Fiber Optic Technology - instrumentation | Protoporphyrins - biosynthesis | Surgery, Computer-Assisted - instrumentation | Surgery, Computer-Assisted - methods | Microscopy, Confocal - methods | Protoporphyrins - analysis | Aminolevulinic Acid - pharmacokinetics | Animals | Glioma - diagnostic imaging | Microscopy, Fluorescence - methods | Neuroendoscopy - instrumentation | Cell Line, Tumor | Mice | Microscopy, Confocal - instrumentation | Fluorescence | Brain | Gliomas | Brain tumors | Index Medicus
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7. Full Text Counterbalancing risks and gains from extended resections in malignant glioma surgery: A supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study: Clinical article
by Stummer, Walter and Tonn, Jörg-Christian and Mehdorn, Hubertus Maximilian and Nestler, Ulf and Franz, Kea and Goetz, Claudia and Bink, Andrea and Pichlmeier, Uwe and Ala-Glioma Study Grp and ALA-Glioma Study Group
Journal of neurosurgery, ISSN 0022-3085, 03/2011, Volume 114, Issue 3, pp. 613 - 623
Malignant glioma | Resection | 5-aminolevulinic acid | Surgical risk | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Biological and medical sciences | Medical sciences | Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases | Neurosurgery | Postoperative Complications - etiology | Humans | Middle Aged | Fluorescence | Male | Consciousness Disorders | Brain Neoplasms - surgery | Young Adult | Nervous System Diseases - epidemiology | Karnofsky Performance Status | Endpoint Determination | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Glioma - surgery | Aminolevulinic Acid | Risk Assessment | Kaplan-Meier Estimate | Surgery, Computer-Assisted - methods | Treatment Outcome | Postoperative Complications - epidemiology | Preoperative Care | Magnetic Resonance Imaging | Dexamethasone - therapeutic use | Image Processing, Computer-Assisted | Photosensitizing Agents | Nervous System Diseases - etiology | Aged | Neurosurgical Procedures - methods | Index Medicus | Abridged Index Medicus
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8. Full Text Microbial production and applications of 5-aminolevulinic acid
by Liu, Shuli and Zhang, Guangming and Li, Xiangkun and Zhang, Jie
Applied microbiology and biotechnology, ISSN 0175-7598, 9/2014, Volume 98, Issue 17, pp. 7349 - 7357
Life Sciences | Biotechnology | 5-Aminolevulinic acid | Biosynthesis pathway | Regulation strategies | Microbiology | Microbial Genetics and Genomics | Microbial production | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Biotechnology - methods | Bacteria - metabolism | Metabolic Networks and Pathways - genetics | Aminolevulinic Acid - metabolism | Aminolevulinic Acid - isolation & purification | Gene Expression Regulation, Bacterial | Bacteria - genetics | Water Purification - methods | Waste Water - microbiology | Physiological aspects | Amino acids | Microorganisms | Analysis | Studies | Bacteria | Biosynthesis | Research | Index Medicus
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9. Full Text Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: A phase II study
by Nabavi, Arya and Thurm, Holger and Zountsas, Basilios and Pietsch, Thorsten and Lanfermann, Heinrich and Pichlmeier, Uwe and Mehdorn, Maximilian and 5-ALA Recurrent Glioma and 5-ALA Recurrent Glioma Study Group
Neurosurgery, ISSN 0148-396X, 12/2009, Volume 65, Issue 6, pp. 1070 - 1076
Recurrent malignant glioma | 5-Aminolevulinic acid | Positive predictive value | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Surgery | Science & Technology | Predictive Value of Tests | Confidence Intervals | Prospective Studies | Follow-Up Studies | Outcome Assessment (Health Care) | Humans | Middle Aged | Brain Neoplasms - pathology | Fluorescence | Magnetic Resonance Imaging - methods | Male | Brain Neoplasms - surgery | Glioma - pathology | Neurosurgery - methods | Adult | Female | Aged | Retrospective Studies | Neurologic Examination - methods | Glioma - surgery | Aminolevulinic Acid | Index Medicus
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