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1. Aldosterone reprograms promoter methylation to regulate alpha ENaC transcription in the collecting cuct
by Yu, Zhiyuan and Kong, Qun and Kone, Bruce C
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 10/2013, Volume 305, Issue 7, pp. F1006 - F1006
Aldosterone increases tubular Na+ absorption largely by increasing alpha -epithelial Na+ channel ( alpha ENaC) transcription in collecting duct principal... 
5-aza-2'-deoxycytidine
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2. Hypomethylating Agents and Other Novel Strategies in Myelodysplastic Syndromes
by Garcia-Manero, Guillermo and Fenaux, Pierre
Journal of Clinical Oncology, ISSN 0732-183X, 02/2011, Volume 29, Issue 5, pp. 516 - 523
Over the last decade, treatment approaches for patients with myelodysplastic syndromes (MDS) have improved significantly. Treatment of MDS is tailored to the... 
5-aza-2'-deoxycytidine
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3. Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells
by Wang, Xiaoli and Zhang, Wei and Tripodi, Joseph and Lu, Min and Xu, Mingjiang and Najfeld, Vesna and Li, Yan and Hoffman, Ronald
Blood, ISSN 1528-0020, 12/2010, Volume 116, Issue 26, pp. 5972 - 5982
Because primary myelofibrosis (PMF) originates at the level of the pluripotent hematopoietic stem cell (HSC), we examined the effects of various therapeutic... 
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4. Full Text DECITABINE PLUS R‐CHOP IN PATIENTS WITH NEWLY DIAGNOSED DIFFUSE LARGE B‐CELL LYMPHOMA: INTERIM RESULTS OF A PHASE I/II STUDY
by Zhang, M and Xu, P and Cheng, S and Wang, L and Zhao, W
Hematological Oncology, ISSN 0278-0232, 06/2019, Volume 37, Issue S2, pp. 528 - 528
Lymphocytes B | Lymphoma | 5-aza-2'-deoxycytidine
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5. Full Text Myeloid leukemia with high EVI1 expression is sensitive to 5-aza-2′-deoxycytidine by targeting miR-9
by Li, F and He, W and Geng, R and Xie, X
Clinical and Translational Oncology, ISSN 1699-048X, 2019
High expression of ecotropic viral integration site 1 (EVI1) has been associated with a poor prognosis in leukemia patients, but the underlying mechanism... 
5-Aza-2′-deoxycytidine | EVI1 | miR-9 | Methylation | Myeloid Leukemia
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6. An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-Targeted Molecular Probes: e78752
by Fagan, Rebecca L and Wu, Meng and Chedin, Frederic and Brenner, Charles
PLoS ONE, 11/2013, Volume 8, Issue 11
DNA methyltransferase 1 (DNMT1) is the enzyme most responsible for epigenetic modification of human DNA and the intended target of approved cancer drugs such... 
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7. Epigenetic Regulation and Functional Characterization of MicroRNA-142 in Mesenchymal Cells: e79231
by Skarn, Magne and Baroey, Tale and Stratford, Eva Wessel and Myklebost, Ola
PLoS ONE, 11/2013, Volume 8, Issue 11
The transcripts encoded by the microRNA mir-142 gene are highly active in hematopoietic cells, but expressed at low levels in many other cell types. Treatment... 
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8. Epigenetic Priming of AML Blasts for All-trans Retinoic Acid-Induced Differentiation by the HDAC Class-I Selective Inhibitor Entinostat: e75258
by Blagitko-Dorfs, Nadja and Jiang, Yi and Duque-Afonso, Jesus and Hiller, Jan and Yalcin, Arzu and Greve, Gabriele and Abdelkarim, Mahmoud and Hackanson, Bjorn and Luebbert, Michael
PLoS ONE, 10/2013, Volume 8, Issue 10
All-trans retinoic acid (ATRA) has only limited single agent activity in AML without the PML-RAR alpha fusion (non-M3 AML). In search of a sensitizing strategy... 
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9. Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells: e75136
by Han, Han and Yang, Xiaojing and Pandiyan, Kurinji and Liang, Gangning
PLoS ONE, 09/2013, Volume 8, Issue 9
Epigenetic gene silencing, mediated by aberrant promoter DNA hypermethylation and repressive histone modifications, is a hallmark of cancer. Although... 
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10. Prolonged Treatment with DNMT Inhibitors Induces Distinct Effects in Promoters and Gene-Bodies. e71099
by Wong, Yan-Fung and Jakt, Lars Martin and Nishikawa, Shin-Ichi
PLoS ONE, 08/2013, Volume 8, Issue 8
Treatment with the demethylating drugs 5-azacytidine (AZA) and decitabine (DAC) is now recognised as an effective therapy for patients with Myelodysplastic... 
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11. Increased PRAME-Specific CTL Killing of Acute Myeloid Leukemia Cells by Either a Novel Histone Deacetylase Inhibitor Chidamide Alone or Combined Treatment with Decitabine. e70522
by Yao, Yushi and Zhou, Jihao and Wang, Lixin and Gao, Xiaoning and Ning, Qiaoyang and Jiang, Mengmeng and Wang, Jia and Wang, Lili and Yu, Li
PLoS ONE, 08/2013, Volume 8, Issue 8
As one of the best known cancer testis antigens, PRAME is overexpressed exclusively in germ line tissues such as the testis as well as in a variety of solid... 
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12. Full Text Targeting the cancer epigenome for therapy
by Jones, Peter A and Issa, Jean-Pierre J and Baylin, Stephen
Nature Reviews Genetics, ISSN 1471-0056, 10/2016, Volume 17, Issue 10, pp. 630 - 641
Next-generation sequencing has revealed that more than 50% of human cancers harbour mutations in enzymes that are involved in chromatin organization. Tumour... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | DNA METHYLATION | TET2 MUTATIONS | 5-AZA-2'-DEOXYCYTIDINE DECITABINE | HYPOMETHYLATING AGENT | TUMOR-SUPPRESSOR GENES | GENETICS & HEREDITY | RISK MYELODYSPLASTIC SYNDROME | ACUTE MYELOID-LEUKEMIA | HISTONE DEACETYLASE INHIBITORS | Epigenomics - methods | Neoplasms - genetics | Epigenesis, Genetic | Humans | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | High-Throughput Nucleotide Sequencing - methods | DNA Methylation - drug effects | Neoplasms - drug therapy | Epigenetic inheritance | Research | Drug discovery | Analysis | Cancer
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13. Full Text Maintenance Therapy With Low-Dose Azacitidine After Allogeneic Hematopoietic Stem Cell Transplantation for Recurrent Acute Myelogenous Leukemia or Myelodysplastic Syndrome
by de Lima, M and Giralt, S and Thall, PF and Silva, LD and Jones, RB and Komanduri, K and Braun, TM and Nguyen, HQ and Champlin, R and Garcia-Manero, G
CANCER, ISSN 0008-543X, 12/2010, Volume 116, Issue 23, pp. 5420 - 5431
BACKGROUND: Recurrence is a major cause of treatment failure after allogeneic transplantation for acute myelogenous leukemia (AML) and myelodysplastic syndrome... 
acute | leukemia | DECITABINE | hematopoietic | 5-AZA-2'-DEOXYCYTIDINE | EFFICACY | stem cell transplantation | ACUTE MYELOID-LEUKEMIA | CANCER | CHEMOTHERAPY | recurrence | myelodysplastic | ONCOLOGY | syndrome | IMMUNOTHERAPY | myelogenous | MALIGNANCIES | OUTCOMES | MARROW TRANSPLANTATION
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14. Methylation of the Claudin 1 Promoter Is Associated with Loss of Expression in Estrogen Receptor Positive Breast Cancer. e68630
by Cello, Francescopaolo Di and Cope, Leslie and Li, Huili and Jeschke, Jana and Wang, Wei and Baylin, Stephen B and Zahnow, Cynthia A
PLoS ONE, 07/2013, Volume 8, Issue 7
Downregulation of the tight junction protein claudin 1 is a frequent event in breast cancer and is associated with recurrence, metastasis, and reduced... 
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15. Overexpression of EGFR in Head and Neck Squamous Cell Carcinoma Is Associated with Inactivation of SH3GL2 and CDC25A Genes. e63440
by Maiti, Guru Prasad and Mondal, Pinaki and Mukherjee, Nupur and Ghosh, Amlan and Ghosh, Susmita and Dey, Sanjib and Chakrabarty, Jayanta and Roy, Anup and Biswas, Jaydip and Roychoudhury, Susanta
PLoS ONE, 05/2013, Volume 8, Issue 5
The aim of this study is to understand the mechanism of EGFR overexpression in head and neck squamous cell carcinoma (HNSCC). For this reason,... 
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16. Low Dose Decitabine Treatment Induces CD80 Expression in Cancer Cells and Stimulates Tumor Specific Cytotoxic T Lymphocyte Responses. e62924
by Wang, Li-Xin and Mei, Zhen-Yang and Zhou, Ji-Hao and Yao, Yu-Shi and Li, Yong-Hui and Xu, Yi-Han and Li, Jing-Xin and Gao, Xiao-Ning and Zhou, Min-Hang and Jiang, Meng-Meng
PLoS ONE, 05/2013, Volume 8, Issue 5
Lack of immunogenicity of cancer cells has been considered a major reason for their failure in induction of a tumor specific T cell response. In this paper, we... 
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17. MicroRNA-219-2-3p Functions as a Tumor Suppressor in Gastric Cancer and Is Regulated by DNA Methylation. e60369
by Lei, Huizi and Zou, Dongling and Li, Zheng and Luo, Min and Dong, Lei and Wang, Bin and Yin, Haixin and Ma, Yanni and Liu, Changzheng and Wang, Fang
PLoS ONE, 04/2013, Volume 8, Issue 4
Background & Aims Gastric cancer is the most frequent gastrointestinal tumor in adults and is the most lethal form of human cancer. Despite of the improvements... 
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18. Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification. e61423
by Fu, Baisheng and Wang, Hongwei and Wang, Jinhua and Barouhas, Ivana and Liu, Wanqing and Shuboy, Adam and Bushinsky, David A and Zhou, Dongsheng and Favus, Murray J
PLoS ONE, 04/2013, Volume 8, Issue 4
Genetic hypercalciuric stone-forming (GHS) rats have increased intestinal Ca absorption, decreased renal tubule Ca reabsorption and low bone mass, all of which... 
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19. Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia. e61807
by Kuang, Shao-Qing and Fang, Zhihong and Zweidler-McKay, Patrick A and Yang, Hui and Wei, Yue and Gonzalez-Cervantes, Emilio A and Boumber, Yanis and Garcia-Manero, Guillermo
PLoS ONE, 04/2013, Volume 8, Issue 4
The Notch pathway can have both oncogenic and tumor suppressor roles, depending on cell context. For example, Notch signaling promotes T cell differentiation... 
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20. DNA Methylation Profiles at Precancerous Stages Associated with Recurrence of Lung Adenocarcinoma. e59444
by Sato, Takashi and Arai, Eri and Kohno, Takashi and Tsuta, Koji and Watanabe, Shun-ichi and Soejima, Kenzo and Betsuyaku, Tomoko and Kanai, Yae
PLoS ONE, 03/2013, Volume 8, Issue 3
The aim of this study was to clarify the significance of DNA methylation alterations at precancerous stages of lung adenocarcinoma. Using single-CpG resolution... 
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