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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2019, Volume 106, Issue 4, pp. 831 - 840
The relevance of endogenous 4β‐hydroxycholesterol (4β‐OHC) plasma concentrations or of the 4β‐OHC/total cholesterol concentration ratio (4β‐OHC ratio) as... 
CYTOCHROME-P450 | IN-VITRO | INHIBITION | INTERINDIVIDUAL VARIABILITY | URINARY 6-BETA-HYDROXYCORTISOL | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | INDUCTION | DRUG-METABOLIZING-ENZYMES | MIDAZOLAM | 4-HYDROXYCHOLESTEROL
Journal Article
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISSN 1482-1826, 07/2019, Volume 22, Issue 1, pp. 332 - 339
Purpose: Hydroxylation activity at the 6 beta-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP)... 
CYP3A | DRUG OXIDATION RATES | IN-VITRO | INHIBITION | METABOLISM | PROGESTERONE | ENZYMES | PHARMACOLOGY & PHARMACY | HUMAN LIVER-MICROSOMES | 6-BETA-HYDROXYCORTISOL
Journal Article
Annals of Clinical Biochemistry, ISSN 0004-5632, 1/2019, Volume 56, Issue 1, pp. 82 - 89
Background The analysis of steroids in biological matrices is challenging. One can apply immunoassay as well as gas and liquid chromatography with various... 
mass spectrometry | Chromatography | statistics | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | WOMEN | GAS-CHROMATOGRAPHY | IMMUNOASSAY | MEDICAL LABORATORY TECHNOLOGY | STEROID-HORMONES | 6-BETA-HYDROXYCORTISOL
Journal Article
The AAPS Journal, ISSN 1550-7416, 9/2019, Volume 21, Issue 5, pp. 1 - 11
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 08/2019, Volume 34, Issue 4, pp. 247 - 252
Accurate prediction of cytochrome P450 (CYP) 3A activity in the early stage of drug development and in clinical practice is important. This study aimed to... 
CYP3A | Midazolam | Endogenous marker | Pharmacometabolomics | Drug-drug interaction | BIOMARKERS | RATIO | PHARMACOLOGY & PHARMACY | MIDAZOLAM CLEARANCE | 4-BETA-HYDROXYCHOLESTEROL | 6-BETA-HYDROXYCORTISOL | CORTISOL | Measurement | Enzyme inhibitors | Drug interactions | Analysis | Cytochrome P-450 | Health aspects | Testing
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 09/2015, Volume 55, Issue 9, pp. 1012 - 1023
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 06/2018, Volume 33, Issue 3, pp. 173 - 178
This study was aimed at evaluating changes in CYP3A activity following and during pregnancy by analyzing metabolic markers for CYP3A activity, which can help... 
Pregnancy | GC-MS | Cytochrome P450 3A | 4β-hydroxycholesterol/cholesterol | Metabolic markers | SAFETY | 6-BETA-HYDROXYCORTISOL | 4-HYDROXYCHOLESTEROL | VARIABILITY | PHARMACOKINETICS | 4 beta-hydroxycholesterol/cholesterol | PHARMACOLOGY & PHARMACY | MIDAZOLAM | DRUG-METABOLISM
Journal Article
Journal Article
ACTA PHARMACOLOGICA SINICA, ISSN 1671-4083, 04/2016, Volume 37, Issue 4, pp. 555 - 560
Aim: To examine how the endogenous CYP3A4 phenotype and CYP3A5*3 genotype of Chinese renal transplant recipients influenced the dose-corrected trough... 
CYP3A53 genotype | tacrolimus | Chinese renal transplant recipients | HUMANS | CHEMISTRY, MULTIDISCIPLINARY | 6-BETA-HYDROXYCORTISOL | P-GLYCOPROTEIN | POLYMORPHISMS | INHIBITION | GENE | CYP3A phenotype | IN-VIVO | PHARMACOLOGY & PHARMACY | CORTISOL | Original
Journal Article