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index medicus (217) 217
biochemistry & molecular biology (181) 181
animals (158) 158
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (129) 129
glycolysis (119) 119
6-phosphofructo-2-kinase fructose-2,6-bisphosphatase (96) 96
fructose 2,6-bisphosphate (95) 95
phosphofructokinase-2 (95) 95
rats (94) 94
humans (90) 90
expression (87) 87
molecular sequence data (77) 77
biophysics (56) 56
amino acid sequence (55) 55
phosphofructokinase-2 - metabolism (53) 53
6-phosphofructo-2-kinase (49) 49
base sequence (49) 49
liver - enzymology (49) 49
phosphorylation (48) 48
male (47) 47
kinetics (46) 46
phosphofructokinase-2 - genetics (44) 44
phosphoric monoester hydrolases - genetics (41) 41
phosphoric monoester hydrolases - metabolism (40) 40
cell biology (39) 39
metabolism (38) 38
bifunctional enzyme (37) 37
glucose (36) 36
binding sites (35) 35
phosphotransferases - genetics (35) 35
phosphotransferases - metabolism (35) 35
fructose-2,6-bisphosphatase (34) 34
liver (34) 34
amino-acid-sequence (33) 33
fructose (33) 33
gene expression (33) 33
messenger-rna (33) 33
enzymes (32) 32
escherichia-coli (32) 32
mice (31) 31
mutagenesis, site-directed (30) 30
phosphoric monoester hydrolases - chemistry (30) 30
crystal-structure (29) 29
site-directed mutagenesis (29) 29
cloning, molecular (28) 28
liver 6-phosphofructo-2-kinase fructose-2,6-bisphosphatase (28) 28
molecular-cloning (28) 28
fructosediphosphates - metabolism (27) 27
rat-liver (27) 27
gene (26) 26
sequence (25) 25
activation (24) 24
fructose-2,6-bisphosphate (24) 24
glucose-metabolism (24) 24
phosphotransferases - chemistry (23) 23
female (22) 22
glucose - metabolism (22) 22
pfkfb3 (21) 21
phosphofructokinase-2 - chemistry (21) 21
isoenzymes - genetics (20) 20
multienzyme complexes - genetics (20) 20
oncology (20) 20
phosphorylation sites (20) 20
testis - enzymology (20) 20
dependent protein-kinase (19) 19
endocrinology & metabolism (19) 19
gene-expression (19) 19
insulin (19) 19
recombinant proteins - metabolism (19) 19
sequence homology, amino acid (19) 19
cell line (18) 18
enzyme (18) 18
enzyme inhibitors - pharmacology (18) 18
hypoxia (18) 18
multienzyme complexes - metabolism (18) 18
rna, messenger - metabolism (18) 18
binding (17) 17
cancer (17) 17
isoenzymes - metabolism (17) 17
mechanism (17) 17
myocardium - enzymology (17) 17
sequence alignment (17) 17
glucose metabolism (16) 16
inhibition (16) 16
physiological aspects (16) 16
proteins (16) 16
research (16) 16
apoptosis (15) 15
bovine heart (15) 15
catalysis (15) 15
fructose 2,6-bisphosphatase (15) 15
genes (15) 15
isoenzymes (15) 15
models, molecular (15) 15
phosphofructokinase-2 - antagonists & inhibitors (15) 15
polymerase chain reaction (15) 15
structure-activity relationship (15) 15
cell proliferation (14) 14
dna (14) 14
fructose-bisphosphatase - genetics (14) 14
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Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 149 - 161
Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells... 
Compound A | 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase | Protein-protein docking | RO-28-1675 | Glucokinase | Mannoheptulose | Pancreatic beta cells | Isoenzymes | Glutathione transferase | Diabetes | Glucose | Fructose | Dextrose | Protein binding | Blood proteins | Index Medicus
Journal Article
FEBS JOURNAL, ISSN 1742-464X, 10/2017, Volume 284, Issue 20, pp. 3437 - 3454
In human cancers, transforming growth factor-1 (TGF-beta 1) plays a dual role by acting as both a tumor suppressor and a promoter of tumor metastasis. Although... 
ACTIVATION | PFKFB3 | TGF-BETA | CANCER-ASSOCIATED FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | glycolysis and glioblastoma | transforming growth factor-beta 1 | CROSS-TALK | INHIBITION | METABOLISM | gene regulation | 6-PHOSPHOFRUCTO-2-KINASE | GROWTH | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2013, Volume 12, Issue 8, pp. 1461 - 1470
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2014, Volume 15, Issue 2, pp. 999 - 1003
Objective: To validate the relationship between MACC1 and 6-phosphofructo-2-kinase/fructose 2, 6 bisphosphatase (PFKFB2) expression as well as its... 
Immunohistochemistry | PFKFB2 | Glycolysis | Hepatocellular carcinoma | MACC1 | CANCER-CELLS | HEXOKINASE 2 | ACTIVATION | METASTASIS | glycolysis | AKT | INHIBITION | ONCOLOGY | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | immunohistochemistry | FRUCTOSE 2,6-BISPHOSPHATE | MET | hepatocellular carcinoma
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 56, pp. 95504 - 95515
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane transporter which is often upregulated in human cancers. However, how this anion transporter... 
Mitochondrial uncoupling 2 | PFKFB2 | Glycolysis | Mitochondria | Skin cells | mitochondria | glycolysis | METABOLIC REQUIREMENTS | CELL BIOLOGY | skin cells | INHIBITION | GENE | PATHWAY | GLUCOSE | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | mitochondrial uncoupling 2 | GENIPIN | DYSFUNCTION | MITOCHONDRIAL UNCOUPLING PROTEIN-2 | EXPRESSION
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2008, Volume 7, Issue 1, pp. 110 - 120
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7700, pp. 249 - 254
Journal Article
Oncotarget, ISSN 1949-2553, 09/2017, Volume 8, Issue 37, pp. 62793 - 62802
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes which regulate the transformation between fructose-2, 6-bisphosphate... 
Glycolysis | Hematologic malignancies | PFKFB3 | Solid tumors | Autophagy | autophagy | glycolysis | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | CELL-GROWTH | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE GENE PFKFB3 | HYPOXIA | solid tumors | CELL BIOLOGY | hematologic malignancies | INHIBITION | GLUCOSE-METABOLISM | FRUCTOSE 2,6-BISPHOSPHATE | ENERGY-METABOLISM | TUMOR-GROWTH | EXPRESSION
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2019, Volume 14, Issue 1, pp. 169 - 181
Journal Article