X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
6-formylindolo[3,2-b]carbazole (19) 19
index medicus (19) 19
aryl hydrocarbon receptor (13) 13
aryl-hydrocarbon receptor (13) 13
toxicology (12) 12
pharmacology & pharmacy (11) 11
ah receptor (10) 10
biochemistry & molecular biology (10) 10
tryptophan (10) 10
animals (9) 9
carbazoles - pharmacology (9) 9
high-affinity (9) 9
receptors, aryl hydrocarbon - metabolism (9) 9
humans (8) 8
expression (7) 7
natural sciences (7) 7
naturvetenskap (7) 7
2,3,7,8-tetrachlorodibenzo-p-dioxin (6) 6
6-formylindolo (6) 6
carbazoles - metabolism (6) 6
cyp1a1 (6) 6
2-b]carbazole (5) 5
activation (5) 5
article (5) 5
biological sciences (5) 5
cytochrome p-450 (5) 5
cytochrome p-450 cyp1a1 - genetics (5) 5
cytochrome p-450 cyp1a1 - metabolism (5) 5
dioxin (5) 5
dioxin receptor (5) 5
human-cells (5) 5
metabolism (5) 5
receptors, aryl hydrocarbon - agonists (5) 5
6-formylindolo[3,2- b]carbazole (4) 4
ah-receptor (4) 4
biologiska vetenskaper (4) 4
carbazole (4) 4
cells, cultured (4) 4
chemical sciences (4) 4
cyp1a1 gene-expression (4) 4
gene expression (4) 4
hydrocarbons (4) 4
induction (4) 4
kemi (4) 4
ligands (4) 4
mice (4) 4
mrna (4) 4
oxidative stress (4) 4
receptors, aryl hydrocarbon - genetics (4) 4
tryptophan - metabolism (4) 4
ultraviolet-b (4) 4
2,3,7,8-tetrachlorodibenzo-p-dioxin = tcdd (3) 3
6-formylindolo<3,2-b>carbazole (3) 3
6-formylindolocarbazole (3) 3
ahr (3) 3
ahr functions (3) 3
biologi (3) 3
biology (3) 3
carbazoles - chemistry (3) 3
cell line (3) 3
cells (3) 3
chemistry, organic (3) 3
cytochrome (3) 3
cytochrome p-450 cyp1a1 - antagonists & inhibitors (3) 3
cytochrome p-450 cyp1a1 - biosynthesis (3) 3
cytochrome p450 (3) 3
cytochrome p4501a1 (3) 3
dermatology (3) 3
developmental toxicity (3) 3
dose-response relationship, drug (3) 3
ellipticine (3) 3
enzyme inhibitors - pharmacology (3) 3
ficz (3) 3
herbicides (3) 3
human keratinocytes (3) 3
identification (3) 3
indoles - pharmacology (3) 3
induced signal-transduction (3) 3
molecular structure (3) 3
polychlorinated dibenzodioxins - pharmacology (3) 3
proteins (3) 3
rodents (3) 3
singlet oxygen (3) 3
skin (3) 3
tcdd (3) 3
toxicity (3) 3
transcription (3) 3
transient induction (3) 3
tryptophan - chemistry (3) 3
ultraviolet rays (3) 3
zebrafish (3) 3
2,3,7,8-tetrachlorodibenzo-p-dioxin tcdd (2) 2
6-formylindolo carbazole (2) 2
6-formylindolo[3,2-b]carbazole = ficz (2) 2
analysis (2) 2
animal structures (2) 2
aromatic compounds (2) 2
autoregulation (2) 2
base sequence (2) 2
bilirubin (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical Pharmacology, ISSN 0006-2952, 06/2016, Volume 110-111, pp. 117 - 129
6-Formylindolo[3,2- ]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that is efficiently metabolized by AHR-regulated cytochrome P4501... 
Cytochrome P4501 | Enzyme inhibition | Aryl hydrocarbon receptor | 6-Formylindolo[3,2-b]carbazole | Zebrafish embryo toxicity | Synergistic receptor activation | FUNDULUS-HETEROCLITUS | ALPHA-NAPHTHOFLAVONE | ZEBRAFISH DANIO-RERIO | POLYCYCLIC AROMATIC-HYDROCARBONS | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | DEVELOPMENTAL TOXICITY | ARYL-HYDROCARBON RECEPTOR | PHARMACOLOGY & PHARMACY | CYTOCHROME P450S | RISK-ASSESSMENT | CELL-LINE | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Edema - genetics | Oligonucleotides, Antisense - metabolism | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Pericardium - metabolism | Pericardium - pathology | Gene Expression Regulation, Developmental | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 CYP1A1 - deficiency | Zebrafish Proteins - agonists | Morpholinos - genetics | Signal Transduction | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Pericardium - drug effects | Receptors, Aryl Hydrocarbon - genetics | Zebrafish | Receptors, Aryl Hydrocarbon - agonists | Edema - metabolism | Morpholinos - metabolism | Feedback, Physiological | Injections | Animals | Oligonucleotides, Antisense - genetics | Benzoflavones - pharmacology | Embryo, Nonmammalian | Edema - chemically induced | Zebrafish Proteins - genetics | Carbazoles - pharmacology | Edema - pathology | Physiological aspects | Mortality | Analysis | Cytochrome P-450 | Index Medicus | zebrafish embryo toxicity | enzyme inhibition | synergistic receptor activation | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Aryl hydrocarbon receptor; Cytochrome P4501; 6-Formylindolo | Biochemistry and Molecular Biology | Natural Sciences | 2-b]carbazole; Enzyme inhibition; Zebrafish embryo toxicity; Synergistic receptor activation
Journal Article
Archives of Toxicology, ISSN 0340-5761, 10/2017, Volume 91, Issue 10, pp. 3365 - 3372
The maintenance of cellular homeostasis is a complex process that is governed by the receipt of prototypical growth and death signals. The endogenous functions... 
Biomedicine, general | Cell growth | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | 6-Formylindolo[3,2- b ]carbazole (FICZ) | Pharmacology/Toxicology | Mitochondrial-dependent pathway | Apoptosis | 6-Formylindolo[3,2-b]carbazole (FICZ) | OXIDATIVE STRESS | AH RECEPTOR | HEPATOMA-CELLS | 6-Formylindolo[3,2-b] carbazole ( FICZ) | CYTOCHROME-C | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)-INDUCED IMMUNOTOXICITY | CYCLE CONTROL | IMMUNE-SYSTEM | RETINOBLASTOMA PROTEIN | ARYL-HYDROCARBON RECEPTOR | TOXICOLOGY | T-CELLS | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Glutathione - metabolism | Cytochromes c - metabolism | Humans | Carbazoles - administration & dosage | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Cytochrome P-450 CYP1A1 - metabolism | Membrane Potential, Mitochondrial - drug effects | Hep G2 Cells | Dose-Response Relationship, Drug | Cell Proliferation - drug effects | Flavonoids - pharmacology | Carbazoles - pharmacology | Carbazoles - metabolism | Flavonoids | Flavones | Growth | Bioflavonoids | Analysis | Cytochrome P-450 | Cytochrome | Oxidative stress | Enzyme activity | Low concentrations | Toxicity | Cytochrome P450 | Homeostasis | Hepatoma | Carbazole | Mitochondria | Enzymatic activity | Aromatic compounds | Cell death | Trace levels | Biocompatibility | Kinetics | Viability | Growth kinetics | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 05/2018, Volume 288, pp. 83 - 90
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 06/2005, Volume 85, Issue 2, pp. 935 - 943
The presence of high affinity ligands for the aryl hydrocarbon receptor (AhR) in cell culture medium has generally been overlooked. Such compounds may confound... 
Tryptophan | Aryl hydrocarbon receptor | 6-formylindolo[3,2-b]carbazole | Light | CYP1A1 MESSENGER-RNA | TRANSIENT INDUCTION | HEPATOCYTES | HIGH-AFFINITY | AH RECEPTOR | aryl hydrocarbon receptor | GENE | light | LIVER | SINGLET OXYGEN | ULTRAVIOLET-B | TOXICOLOGY | EXPRESSION | tryptophan | Carbazoles - chemistry | Cytochrome P-450 CYP1A1 - radiation effects | Tryptophan - chemistry | Riboflavin - pharmacology | Tryptophan - metabolism | Carbazoles - radiation effects | Liver Neoplasms, Experimental - metabolism | Photosensitizing Agents - pharmacology | Spectrometry, Mass, Electrospray Ionization | Teratogens - pharmacology | Culture Media | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - radiation effects | Enzyme Inhibitors - chemistry | Enzyme Induction - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Indoles - pharmacology | Photochemistry | Indoles - radiation effects | Enzyme Inhibitors - pharmacology | Rats | Receptors, Aryl Hydrocarbon - drug effects | Enzyme Inhibitors - radiation effects | Cytochrome P-450 CYP1A1 - metabolism | Animals | Cell Line, Tumor | Cytochrome P-450 CYP1A1 - biosynthesis | Carbazoles - pharmacology | Indoles - chemistry | Index Medicus | Teratogens | Cytochrome P-450 CYP1A1/biosynthesis/metabolism/radiation effects | Enzyme Inhibitors/chemistry/pharmacology/radiation effects | Spectrometry; Mass; Electrospray Ionization | Biology | Chemical Sciences | Indoles/chemistry/pharmacology/radiation effects | Analytical Chemistry | Enzyme Induction/drug effects | Biochemistry and Molecular Biology | Biologi | Natural Sciences | Biological Sciences | Riboflavin/pharmacology | Photosensitizing Agents/pharmacology | Liver Neoplasms; Experimental/metabolism | Receptors; Aryl Hydrocarbon/drug effects/metabolism/radiation effects | Tryptophan/chemistry/metabolism | Chemistry | Naturvetenskap | Biokemi och molekylärbiologi | Kemi | Biologiska vetenskaper | Cell Line; Tumor | Cell and molecular biology | Analytisk kemi | Carbazoles/chemistry/pharmacology/radiation effects | Cell- och molekylärbiologi
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2009, Volume 181, Issue 3, pp. 447 - 454
Journal Article
Tetrahedron, ISSN 0040-4020, 2003, Volume 59, Issue 8, pp. 1265 - 1275
Double Fischer cyclisation was used to prepare indolo[3,2-b]carbazole and its 2,8-di-OMe, OH, Br and F-derivatives. N-monosubstituted derivatives of... 
indolo[3,2- b]carbazole | Fischer cyclisation | Ah-receptor | Indolo[3,2-b]carbazole | CELLS | TCDD AH RECEPTOR | DNA | EXTREMELY EFFICIENT LIGAND | indolo[3,2-b]carbazole | CYP1A1 | ELLIPTICINE | CHEMISTRY, ORGANIC | 6-FORMYLINDOLO<3,2-B>CARBAZOLE | Naturvetenskap | Natural Sciences | Organisk kemi | Kemi | Chemical Sciences | Organic Chemistry
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 06/2004, Volume 2004, Issue 12, pp. 2593 - 2602
Synthesis of the five mono- and di-hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6-formylindolo[3,2-b]carbazole is described.... 
6-Formylindolo[3,2-b]carbazole | Ah receptor | Metabolite | Acylations | Bis(indoles) | bis(indoles) | 6-formylindolo[3,2-b]carbazole | metabolite | acylations | HIGH-AFFINITY | CHEMISTRY, ORGANIC | HYDROCARBON RECEPTOR | Naturvetenskap | Natural Sciences | Organisk kemi | Kemi | Chemical Sciences | Organic Chemistry
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 1998, Volume 110, Issue 1, pp. 39 - 55
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 21, pp. 8851 - 8856
UVB radiation-induced signaling in mammalian cells involves two major pathways: one that is initiated through the generation of DNA photoproducts in the... 
Receptors | Messenger RNA | Cell nucleus | Cell lines | Irradiation | Ligands | Cell membranes | Skin | Chromophores | Cells | UVB | EGF receptor | 6-formylindolo[3,2-b]carbazole | Cyclooxygenase-2 | Src | HUMAN SKIN | src | PROTEIN-KINASE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | cyclooxygenase-2 | AH RECEPTOR | INDUCED SIGNAL-TRANSDUCTION | GROWTH-FACTOR RECEPTOR | ARYL-HYDROCARBON RECEPTOR | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | CYP1A1 GENE-EXPRESSION | C-SRC | Cytochrome P-450 CYP1A1 - genetics | Receptors, Aryl Hydrocarbon - deficiency | Carbazoles - chemistry | Humans | Cytoplasm - metabolism | Tryptophan - metabolism | Indoles - metabolism | Receptor, Epidermal Growth Factor - metabolism | Cell Nucleus - metabolism | Ultraviolet Rays | Receptors, Aryl Hydrocarbon - metabolism | Molecular Structure | Active Transport, Cell Nucleus | Signal Transduction - radiation effects | Basic Helix-Loop-Helix Transcription Factors | Carbazoles - metabolism | Cell Line | Cytoplasm - radiation effects | Gene Expression Regulation | Receptors, Aryl Hydrocarbon - genetics | Cytochrome P-450 CYP1A1 - metabolism | Mice, Knockout | Animals | Proto-Oncogene Proteins pp60(c-src) - metabolism | Mice | Transcription, Genetic - genetics | Indoles - chemistry | COX-2 inhibitors | Ultraviolet radiation | Research | Hydrocarbons | Cellular biology | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 01/2018, Volume 89, Issue 1, pp. 19 - 26
Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major... 
6-Formylindolo[3,2-b]carbazole | Aryl hydrocarbon receptor | Dermal fibroblast | FICZ | Ultraviolet | Photo-aging | OXIDATIVE STRESS | HUMAN-CELLS | MYOFIBROBLAST | INDUCED SIGNAL-TRANSDUCTION | HUMAN KERATINOCYTES | DERMATOLOGY | INDUCED CYP1A1 | ARYL-HYDROCARBON RECEPTOR | HUMAN SKIN FIBROBLASTS | ULTRAVIOLET-B | EXPRESSION | Index Medicus
Journal Article
JOURNAL OF DERMATOLOGICAL SCIENCE, ISSN 0923-1811, 07/2018, Volume 91, Issue 1, pp. 97 - 103
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2005, Volume 85, Issue 2, p. 935
The presence of high affinity ligands for the aryl hydrocarbon receptor (AhR) in cell culture medium has generally been overlooked. Such compounds may confound... 
tryptophan; 6-formylindolo | 2-b]carbazole; light; aryl hydrocarbon receptor
Journal Article