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Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 18, pp. 14160 - 14174
Oxysterols are cholesterol oxygenated derivatives which possess several biological actions. Among oxysterols, 7-ketocholesterol (7KC) is known to induce cell... 
Cell death | 7-ketocholesterol | Melanoma | Nanoemulsion | LDL receptor
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2013, Volume 86, Issue 1, pp. 146 - 153
11β-Hydroxysteroid dehydrogenase 1 (11βHSD1; EC 1.1.1.146) generates active glucocorticoids from inert 11-keto metabolites. However, it can also metabolize... 
7β-Hydroxycholesterol | 11β-Hydroxysteroid dehydrogenase 1 | 7-Oxysterols | 7-Ketocholesterol | Glucocorticoids | Corticosterone
Journal Article
CLINICAL SCIENCE, ISSN 0143-5221, 10/2019, Volume 133, Issue 19, pp. 2023 - 2028
Endoplasmic reticulum (ER) and mitochondria are crucial organelles for cell homeostasis and alterations of these organelles have been implicated in... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | UNFOLDED PROTEIN RESPONSE | ANGIOTENSIN-II | MECHANISMS | MODEL | ER | 7-KETOCHOLESTEROL | DEFICIENCY | FAMILY
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2013, Volume 86, Issue 1, pp. 67 - 79
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019, Volume 517, Issue 4, pp. 715 - 721
Dyslipidemia causes renal damage; however, the detailed molecular mechanism has not been clarified. It is known that carnitine palmitoyl transferase 1-a... 
Kidney epithelial cells | NLRP3 | CPT1a | 7-Ketocholesterol | Fibrosis | ACTIVATION | OBESITY | BIOPHYSICS | FATTY-ACID OXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KIDNEY
Journal Article
by Cho, HR and Son, Y and Kim, SM and Kim, BY and Eo, SK and Park, YC and Kim, K
PLOS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3
We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7 alpha-hydroxycholesterol (7 alpha OHChol), 7... 
ATHEROSCLEROTIC LESIONS | INHIBITION | HUMAN MACROPHAGES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ACCUMULATION | NF-KAPPA-B | MONOCYTIC CELLS | 7-KETOCHOLESTEROL | OXYSTEROLS
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 09/2019, Volume 60, Issue 9, pp. 1535 - 1546
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles... 
oxysterol | ACID | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | mineralocorticoid receptor | 7-KETOCHOLESTEROL | retinoid-related orphan receptor gamma | INHIBITION | 27-hydroxylase | HEPATIC-METABOLISM | TYPE-1 | EXPRESSION | STEROL 27-HYDROXYLASE | OXYSTEROLS
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2019, Volume 190, pp. 19 - 28
[Display omitted] •hydroxylation of 7-ketocholesterol to 7-keto,25-hydroxycholesterol (7k25OHC) by CH25H.•stereospecific reduction of 7k25OHC to... 
11beta-hydroxysteroid dehydrogenase | Epstein-Barr virus-induced gene 2 | Metabolism | 7-ketocholesterol | Cholesterol 25-hydroxylase | Oxysterol | Molecular modelling | Metabolites | Glucocorticoids | Hydroxylase | 11β-Hydroxysteroid dehydrogenase | Lipids | Oxidation | Cholesterol | Index Medicus
Journal Article
CLINICAL SCIENCE, ISSN 0143-5221, 07/2019, Volume 133, Issue 13, pp. 1421 - 1438
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical management of AAA is... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | RISK-FACTORS | UNFOLDED PROTEIN | ER STRESS | ENDOTHELIAL-CELLS | SMOOTH-MUSCLE-CELLS | AUTOPHAGY | DYSFUNCTION | PLASMA 7-KETOCHOLESTEROL | OXYSTEROLS
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 10/2015, Volume 56, Issue 10, pp. 1926 - 1935
Niemann-Pick type C (NPC) is a progressive neurodegenerative disease characterized by lysosomal/endosomal accumulation of unesterified cholesterol and... 
HUMAN-SERUM | CHOLESTEROL | oxysterols | BIOCHEMISTRY & MOLECULAR BIOLOGY | electrospray ionization | MASS-SPECTROMETRY | HEPATIC LEVELS | tandem mass spectrometry | PLASMA | 3 alpha,7 alpha,12 alpha-trihydroxycoprostane | MS/MS METHOD | 7-ketocholesterol | BIOSYNTHESIS | DISEASE | high-performance liquid chromatography | RAPID DIAGNOSIS
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 03/2010, Volume 75, Issue 5, pp. 1807 - 1810
An allylic oxidation method for Delta(5)-steroids using TBHP as oxidant with a 2-quinoxalinol salen Cu(II) complex as catalyst is reported. A variety of... 
REAGENT | LOCALIZATION | ALKENES | DIRHODIUM CAPROLACTAMATE | CHEMISTRY, ORGANIC | 7-KETOCHOLESTEROL | OXYSTEROLS
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 12/2007, Volume 9, Issue 26, pp. 5349 - 5352
Dirhodium caprolactamate is the most efficient catalyst for the oxidation of Delta(5)-steroids to 7-keto-Delta(5)-steroids by 70% tert-butyl hydroperoxide in... 
REARRANGEMENT | LOCALIZATION | ACTIVATION | T-BUTYL HYDROPEROXIDE | STEROIDS | COMPLEXES | CHEMISTRY, ORGANIC | RADICALS | DERIVATIVES | 7-KETOCHOLESTEROL | OXYSTEROLS
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2018, Volume 505, Issue 4, pp. 1043 - 1049
Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death.... 
Annexin V | KI67 | Oxysterol | Apoptosis | Cancer | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROLS | 7-KETOCHOLESTEROL-INDUCED APOPTOSIS | PROLIFERATION | INDUCTION | RADIATION | BIOPHYSICS | OXIAPOPTOPHAGY | 7-BETA-HYDROXYCHOLESTEROL | STRESS | CYTOTOXICITY | Oxides | Melanoma | Tumors
Journal Article