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Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5
Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three... 
Biased signaling | Chemokine system | b-arrestin recruitment | Ligand/receptor/tissue bias | Pathway-specific drug development | 7TM-receptor | 7TM structure-function | G protein coupling | biased signaling | chemokine system | ligand/receptor/tissue bias
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2008, Volume 153, Issue S2, pp. S4 - S95
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 06/2014, Volume 5
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2007, Volume 21, Issue 10, pp. 2455 - 2465
Opiates are analgesics of choice in the treatment of chronic pain, but their long-term use leads to the development of physiological tolerance. Thus,... 
Morphine | Oligomerization | 7TM receptors | G-protein-coupled receptors | Enkephalin | Narcotic addiction | enkephalin | narcotic addiction | oligomerization | morphine
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 05/2012, Volume 81, Issue 5, pp. 710 - 718
Acetylcholine activates nicotinic acetylcholine receptors (nAChRs) by binding to an extracellular site located at the interface of two adjacent subunits. In... 
TRANSMEMBRANE SITE | LIGAND-BINDING | 7TM RECEPTORS | TARGETS | PHARMACOLOGY & PHARMACY | BINDING-SITES | AGONIST | SUBUNIT
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2014, Volume 5, p. 277
Biased signaling or functional selectivity occurs when a 7TM-receptor preferentially activates one of several available pathways. It can be divided into three... 
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 07/2019, Volume 491, p. 110397
In this review article, we summarize the current knowledge on a large and diverse superfamily of seven-pass transmembrane proteins functionally independent... 
7TM | Hydrolase | Adiponectin receptors | ADIPOR | Amidase | Intramembrane ceramidases | Structural biology | FATTY-ACID OXIDATION | CERAMIDES | SPHINGOSINE-1-PHOSPHATE | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 3, pp. 886 - 898
The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn2+. We used a homology model-based approach to identify small-molecule... 
CHEMISTRY, MEDICINAL | 7TM RECEPTORS | LIGANDS | CRYSTAL-STRUCTURE | GHRELIN | DRUG DISCOVERY | IN-VIVO | ZINC RECEPTOR | ALLOSTERIC MODULATION | IDENTIFICATION | BETA-ADRENERGIC RECEPTOR
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2015, Volume 150, pp. 129 - 142
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2013, Volume 2, Issue 4, pp. 376 - 392
Abstract The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone ghrelin remain unclear. Based on qPCR analysis of... 
Endocrinology & Metabolism | Enteroendocrine | GPCR | G protein signaling | Metabolites | Ghrelin | Secretion | ENDOCRINOLOGY & METABOLISM
Journal Article