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Cell, ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1005 - 1018
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function... 
PROTEINS | HUMDISEASE | PROTEIN-KINASE-A | APOPTOSIS | CELLS | TARGETED DISRUPTION | IN-VITRO | PROTECTION | TRANSCRIPTION FACTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HSF1 | THERMOTOLERANCE | EXPRESSION | CELL BIOLOGY | ras Proteins - genetics | Protein Biosynthesis | Tetradecanoylphorbol Acetate | Cell Proliferation | Skin - metabolism | Humans | Transcription Factors - deficiency | Gene Expression Regulation, Neoplastic | Methylnitronitrosoguanidine | ras Proteins - metabolism | DNA-Binding Proteins - deficiency | Tumor Suppressor Protein p53 - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Carcinogens | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Skin - pathology | Fibroblasts - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins c-sis - genetics | Transduction, Genetic | Proto-Oncogene Proteins c-sis - metabolism | Cell Survival | Tumor Suppressor Protein p53 - metabolism | Genotype | Signal Transduction - genetics | Skin Neoplasms - chemically induced | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Fibroblasts - pathology | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Skin Neoplasms - genetics | Cell Line, Tumor | Glucose - metabolism | 9,10-Dimethyl-1,2-benzanthracene | Mice | Mice, Inbred BALB C | Mutation | Cell Transformation, Neoplastic - pathology | RNA, Small Interfering - metabolism | Heat shock proteins | Knowledge-based systems
Journal Article
Science, ISSN 0036-8075, 1/2012, Volume 335, Issue 6064, pp. 104 - 108
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 45, pp. 18384 - 18389
A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin... 
Myeloid cells | Cytokines | Skin cancers | Keratinocytes | Epidermis | Mice | Skin | Inflammation | Tumors | Cancer | Innate immunity | Interleukin-1 | Epithelial skin cancer | CELLS | APOPTOSIS | ACTIVATION | interleukin-1 | epithelial skin cancer | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | OVARIAN-CANCER | ABERRANT METHYLATION | innate immunity | GENE | TMS1/ASC | RECRUITMENT DOMAIN PROTEIN | EXPRESSION | Inflammation - pathology | Tetradecanoylphorbol Acetate | Cell Proliferation | Inflammasomes - metabolism | Humans | Tumor Microenvironment | Caspase 1 - metabolism | Cytoskeletal Proteins - deficiency | Skin Neoplasms - prevention & control | Receptors, Interleukin-1 - deficiency | Cytoskeletal Proteins - metabolism | Neoplasms, Squamous Cell - pathology | Skin - pathology | Skin Neoplasms - pathology | Epithelium - pathology | Epithelium - metabolism | Down-Regulation | Tumor Suppressor Protein p53 - metabolism | Organ Specificity | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Apoptosis Regulatory Proteins | Keratinocytes - metabolism | CARD Signaling Adaptor Proteins | Caspase 1 - deficiency | Myeloid Cells - metabolism | 9,10-Dimethyl-1,2-benzanthracene | Myeloid Cells - pathology | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Cytokines - biosynthesis | Epithelial tumors | Development and progression | Research | Health aspects | Carcinogenesis | Skin cancer | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2012, Volume 122, Issue 9, pp. 3127 - 3144
The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through... 
ATHEROSCLEROTIC LESIONS | COLON-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | IMMUNE CELLS | INTESTINAL NEOPLASIA | PROSTATE-CANCER | SKIN CARCINOGENESIS | RECEPTOR D6 | MYELOID CELLS | BEARING MICE | Dextran Sulfate | Tetradecanoylphorbol Acetate | Adenocarcinoma - pathology | Colitis - pathology | Colonic Neoplasms - chemically induced | Mice, 129 Strain | Receptors, Interleukin-8B - antagonists & inhibitors | Receptors, Interleukin-8B - deficiency | Colonic Neoplasms - metabolism | Adenoma - metabolism | Adenocarcinoma - metabolism | Azoxymethane | Colitis - chemically induced | Statistics, Nonparametric | Papilloma - pathology | Precancerous Conditions - pathology | Neutrophils - metabolism | Papilloma - chemically induced | Papilloma - metabolism | Skin Neoplasms - pathology | Dermatitis, Contact - pathology | Gene Expression | Neutrophils - enzymology | Mice, Inbred C57BL | Skin Neoplasms - chemically induced | Tumor Burden | Chemokines, CXC - genetics | Chemokines, CXC - secretion | Mice, Knockout | Skin Neoplasms - metabolism | Animals | Cell Transformation, Neoplastic | Adenoma - secretion | Chemokines, CXC - metabolism | Receptors, Interleukin-8B - genetics | Animals, Inbred Strains | 9,10-Dimethyl-1,2-benzanthracene | Mice | Mice, Inbred BALB C | Precancerous Conditions - chemically induced | Colonic Neoplasms - secretion | Adenoma - chemically induced | Peroxidase - metabolism | Care and treatment | Cancer cells | Neutrophils | Papilloma | Genetic aspects | Diagnosis | Adenoma | Research | Gene expression
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 05/2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Research Paper
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. 1788 - 1804.e13
Journal Article
Journal Article
Carcinogenesis, ISSN 0143-3334, 06/2013, Volume 34, Issue 6, pp. 1315 - 1322
During the process of skin tumor promotion, expression of the cutaneous cancer stem cell (CSC) marker CD34 is required for stem cell activation and tumor... 
KAPPA-B ACTIVATION | INHIBITION | PRODRUG | ONCOLOGY | PROTEIN-KINASE-D | MOUSE EPIDERMIS | TEA POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE | PROLIFERATION | DIFFERENTIATION | CANCER | EXPRESSION | Vascular Endothelial Growth Factor A - biosynthesis | Nitric Oxide Synthase Type II - biosynthesis | Tetradecanoylphorbol Acetate | Antigens, CD34 - metabolism | Extracellular Signal-Regulated MAP Kinases - drug effects | Skin Neoplasms - drug therapy | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Stem Cells - metabolism | Cyclooxygenase 2 - biosynthesis | Skin Neoplasms - prevention & control | Protein Kinase C - metabolism | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | Ornithine Decarboxylase - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Catechin - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Antigens, CD34 - biosynthesis | Chemoprevention | Mitogen-Activated Protein Kinase 8 - metabolism | Protein Kinase C - antagonists & inhibitors | Mice, Inbred ICR | Mitotic Index | Animals | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Stem Cells - drug effects | 9,10-Dimethyl-1,2-benzanthracene | Acetates - pharmacology | Catechin - analogs & derivatives | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 11/2005, Volume 25, Issue 22, pp. 10040 - 10051
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 02/2009, Volume 7, Issue 2, pp. 266 - 274
Estrogen, a naturally occurring female steroid growth hormone, has been implicated as a major risk factor for the development of breast cancer. Recent research... 
growth arrest | ERK1/2 | proliferation | breast | estradiol | LIPOCORTIN 1 | ACTIVATION | METABOLITES | RAT | ONCOLOGY | PHOSPHORYLATION | IN-VIVO | ESTRADIOL | RECEPTOR-BETA | PROLIFERATION | EXPRESSION | CELL BIOLOGY | 9,10-Dimethyl-1,2-benzanthracene - toxicity | Up-Regulation | Phosphorylation | Adenocarcinoma - pathology | Cell Proliferation | Estrogens - pharmacology | Luciferases - metabolism | Humans | Carcinoma, Intraductal, Noninfiltrating - metabolism | Gene Expression Regulation, Neoplastic | Carcinoma, Medullary - metabolism | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Carcinogens - toxicity | Adenocarcinoma - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Carcinoma, Ductal, Breast - pathology | Estrogen Receptor alpha - metabolism | Female | Carcinoma, Ductal, Breast - metabolism | Annexin A1 - physiology | Signal Transduction | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Annexin A1 - antagonists & inhibitors | Carcinoma, Medullary - pathology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Blotting, Western | Animals | Carcinoma, Intraductal, Noninfiltrating - pathology | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Cyclic AMP Response Element-Binding Protein - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article