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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2014, Volume 57, Issue 9, pp. 3623 - 3650
The adenosine A(2A) receptor is a G-protein-coupled receptor (GPCR) that has been extensively studied during the past few decades because it offers numerous... 
MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | POSITRON-EMISSION-TOMOGRAPHY | PHARMACOLOGICAL CHARACTERIZATION | LEAD OPTIMIZATION | STRUCTURE-AFFINITY RELATIONSHIPS | SELECTIVE AGONISTS | ALLOSTERIC MODULATION | BINDING CHARACTERISTICS | DOPAMINE-D-2 RECEPTORS | PARKINSONS-DISEASE
Journal Article
NATURE, ISSN 0028-0836, 06/2011, Volume 474, Issue 7352, pp. 521 - U154
Adenosine receptors and beta-adrenoceptors are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins on binding the agonists adenosine(1)... 
CRYSTALLIZATION | ADRENOCEPTOR | COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | THERMOSTABILIZATION | STABILITY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | PROTEIN-COUPLED RECEPTORS | BINDING
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2015, Volume 112, Issue 27, pp. E3609 - E3618
Adenosine A(2A) receptor (A(2A)R)-dopamine D-2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the... 
GPCR heteromers | HETEROMERS | dopamine D-2 receptor | caffeine | DETERMINANTS | AFFINITY | MULTIDISCIPLINARY SCIENCES | COMPLEXES | adenosine A(2A) receptor
Journal Article
CHEMICAL REVIEWS, ISSN 0009-2665, 01/2017, Volume 117, Issue 1, pp. 21 - 37
Over the past decade there has been a revolution in the field of G protein-coupled receptor (GPCR) structural biology. Many years of innovative research from... 
LIPIDIC CUBIC PHASE | CRYSTAL-STRUCTURE | DRUG DESIGN | PROTEIN-COUPLED RECEPTORS | PSYCHIATRIC-DISORDERS | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | X-RAY STRUCTURES | DOPAMINE TRANSPORTER | CHEMISTRY, MULTIDISCIPLINARY | BOUND CONFORMATION | PARKINSONS-DISEASE
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2017, Volume 127, Issue 3, pp. 929 - 941
Journal Article
Journal Article
Structure, ISSN 0969-2126, 09/2011, Volume 19, Issue 9, pp. 1283 - 1293
Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via... 
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4312 - 4323
A new approach to generating information on ligand receptor interactions within the binding pocket of G protein-coupled receptors has been developed, called... 
POTENT | CHEMISTRY, MEDICINAL | MODELS | CRYSTAL-STRUCTURE | THERMOSTABILIZATION | STABILITY | PROTEIN-COUPLED RECEPTORS | GPCR | ANTAGONISTS | BINDING
Journal Article
MOVEMENT DISORDERS, ISSN 0885-3185, 07/2013, Volume 28, Issue 8, pp. 1138 - 1141
Background: We evaluated the efficacy and safety of istradefylline, a selective adenosine A(2A) receptor antagonist administered as adjunctive treatment to... 
TRIAL | MOTOR FLUCTUATIONS | KW-6002 | Parkinson's disease | wearing-off | MPTP-TREATED MONKEYS | levodopa | DYSKINESIA | istradefylline | motor complications | CLINICAL NEUROLOGY
Journal Article
Psychopharmacology, ISSN 0033-3158, 07/2017, Volume 234, Issue 13, pp. 2031 - 2046
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 53, Issue 3, pp. 439 - 452
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of... 
HUMDISEASE | MOLNEURO | SIGNALING
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 06/2015, Volume 87, Issue 6, pp. 907 - 915
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