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Journal Article
Purinergic Signalling, ISSN 1573-9538, 9/2015, Volume 11, Issue 3, pp. 389 - 407
Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on affinity/potency and selectivity of AR ligands described in the literature... 
Neurosciences | Agonist | Biomedicine | Human Physiology | Cancer Research | Selectivity | Potency | Antagonist | Pharmacology/Toxicology | Species differences | Biomedicine general | XANTHINE DERIVATIVES | NEUROSCIENCES | STRIATAL MEMBRANES | PROTEIN-COUPLED ADENOSINE | P2Y RECEPTORS | A(2B) RECEPTORS | INTERNATIONAL UNION | LIGANDS | A(2A) RECEPTOR | HIGHLY POTENT | PARKINSONS-DISEASE | Cricetulus | Species Specificity | Humans | DNA, Complementary - genetics | Adenosine A1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Agonists - metabolism | Receptor, Adenosine A2B - genetics | Structure-Activity Relationship | Adenosine A1 Receptor Antagonists - metabolism | Adenosine A2 Receptor Antagonists - metabolism | Adenosine A2 Receptor Agonists - pharmacology | Adenosine A3 Receptor Agonists - pharmacology | Adenosine A1 Receptor Agonists - pharmacology | Receptor, Adenosine A2B - drug effects | Receptor, Adenosine A2A - genetics | Adenosine A3 Receptor Antagonists - pharmacology | Cell Membrane - metabolism | Adenosine A3 Receptor Agonists - metabolism | Cyclic AMP - metabolism | Arrestin - metabolism | Cell Membrane - drug effects | DNA, Complementary - drug effects | CHO Cells | Cricetinae | Receptors, Purinergic P1 - genetics | Rats | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A2B - metabolism | Receptor, Adenosine A2A - drug effects | Binding, Competitive - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Adenosine A1 Receptor Agonists - metabolism | Adenosine A3 Receptor Antagonists - metabolism | Mice | Receptors, Purinergic P1 - metabolism | Receptors, Purinergic P1 - drug effects | Adenosine | Original
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 20, pp. 8485 - 8490
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 232 - 236
Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been... 
Molecules | Receptors | Sodium | Molecular structure | REPORTS | Lipids | Ligands | Cell membranes | Cholesterols | Water channels | Crystal structure | ANGSTROM CRYSTAL-STRUCTURE | COMPLEX | ANTAGONIST | OPIOID RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | PROTEIN-COUPLED RECEPTORS | ADENOSINE A(2A) RECEPTOR | ALPHA-2-ADRENERGIC RECEPTORS | MODULATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Allosteric Regulation | Humans | Crystallography, X-Ray | Adenosine A2 Receptor Agonists - metabolism | Recombinant Fusion Proteins - metabolism | Cholesterol - chemistry | Adenosine A2 Receptor Antagonists - metabolism | Lipids - chemistry | Lipid Bilayers | Sodium - analysis | HEK293 Cells | Protein Engineering | Water - chemistry | Triazines - metabolism | Protein Structure, Secondary | Models, Molecular | Receptor, Adenosine A2A - metabolism | Recombinant Fusion Proteins - chemistry | Triazoles - metabolism | Hydrogen Bonding | Receptor, Adenosine A2A - chemistry | Protein Conformation | Cytochrome b Group - chemistry | Escherichia coli Proteins - chemistry | Chemistry | G proteins | Chemical properties | Research | Receptor-mediated endocytosis | Proteins | Ions | Adenosine | Pharmacology | Binding | Control | Stabilization | Strategy | Channels | BASIC BIOLOGICAL SCIENCES | STABILIZATION | CLATHRATES | RESOLUTION | ADENOSINE | REGULATIONS | 60 APPLIED LIFE SCIENCES | RESIDUES | SODIUM IONS | LIPIDS | WATER
Journal Article