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a20 (576) 576
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nf-kappa-b (392) 392
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activation (260) 260
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tumor necrosis factor alpha-induced protein 3 (226) 226
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tumor necrosis factor alpha-induced protein 3 - genetics (63) 63
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multidisciplinary sciences (58) 58
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mice, inbred c57bl (57) 57
responses (57) 57
enzyme a20 (55) 55
medicine, research & experimental (55) 55
rheumatoid-arthritis (55) 55
editing enzyme a20 (54) 54
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rodents (51) 51
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tnf (47) 47
cell-death (46) 46
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immunity (46) 46
systemic-lupus-erythematosus (46) 46
tumor necrosis factor alpha-induced protein 3 - metabolism (46) 46
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International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 02/2010, Volume 42, Issue 2, pp. 329 - 336
Vitamin D receptor plays an essential role in the regulation of inflammation. Previous studies demonstrate that vitamin D receptor negatively modulates the... 
NF-κB | Inflammation | Vitamin D | Vitamin D receptor | IκBα | IMMUNITY | DOUBLE-STRANDED-RNA | ENZYME A20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INNATE | CELL BIOLOGY | NF-kappa B | I kappa B alpha | DISEASE | 1,25-DIHYDROXYVITAMIN D-3 | EXPRESSION | DOMAINS
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 105 - 114
Journal Article
Trends in Immunology, ISSN 1471-4906, 2013, Volume 35, Issue 1, pp. 22 - 31
Highlights • A20 (TNFAIP3) functions are cell-type dependent. • A20 exerts its activities via multiple mechanisms including ubiquitin editing. • A20 expression... 
Allergy and Immunology | nuclear factor-κB | apoptosis | tumor necrosis factor α-induced protein 3 | inflammation | ubiquitination | A20 | Tumor necrosis factor α-induced protein 3 | Ubiquitination | Inflammation | Nuclear factor-κB | Apoptosis | RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | IMMUNE HOMEOSTASIS | tumor necrosis factor alpha-induced protein 3 | LINEAR UBIQUITINATION | nuclear factor-kappa B | CELL-PROLIFERATION | IMMUNOLOGY | FEEDBACK INHIBITION | EDITING ENZYME A20 | NEGATIVE REGULATOR | ZINC-FINGER PROTEIN | NF-KAPPA-B | Autoimmunity | Intestinal Mucosa - metabolism | Skin - metabolism | Humans | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - deficiency | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Inflammation - metabolism | Intestinal Mucosa - immunology | Myeloid Cells - immunology | Nuclear Proteins - deficiency | Cell Death | Tumor Necrosis Factor alpha-Induced Protein 3 | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Disease Models, Animal | Skin - immunology | Gene Targeting | Genetic Predisposition to Disease | Nuclear Proteins - metabolism | Inflammation - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Inflammation - etiology | Animals | B-Lymphocytes - immunology | Myeloid Cells - metabolism | Mice | Enzyme Activation | Ubiquitin | Genetic transcription | Proteins | Studies | Antigens | Rodents | Homeostasis | Regulation | Kinases
Journal Article
BLOOD, ISSN 0006-4971, 12/2013, Volume 122, Issue 25, pp. 4068 - 4076
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2012, Volume 31, Issue 19, pp. 3856 - 3870
Journal Article
Oncogene, ISSN 0950-9232, 03/2013, Volume 32, Issue 10, pp. 1223 - 1232
Kaposi's sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-kappa B... 
AIDS | endothelial cells | KSHV | Kaposi's sarcoma | NF-kB | vFLIP/K13 | KSHV VFLIP | IKK-GAMMA | ENZYME A20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEPENDENT GENE-EXPRESSION | A20 INTERACTS | CELL BIOLOGY | KINASE COMPLEX | UBIQUITIN CHAINS | NF-kappa B | ONCOLOGY | ENDOTHELIAL-CELLS | GENETICS & HEREDITY | ZINC-FINGER PROTEIN | Sarcoma, Kaposi - metabolism | Humans | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Viral Proteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Herpesvirus 8, Human - metabolism | Nuclear Proteins - biosynthesis | Tumor Necrosis Factor alpha-Induced Protein 3 | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | NF-kappa B - antagonists & inhibitors | Transduction, Genetic | Endothelial Cells - metabolism | Viral Proteins - genetics | Herpesvirus 8, Human - genetics | Nuclear Proteins - metabolism | Viral Proteins - antagonists & inhibitors | Sarcoma, Kaposi - virology | DNA-Binding Proteins - genetics | Intracellular Signaling Peptides and Proteins - biosynthesis | Sarcoma, Kaposi - pathology | Proteins - genetics | Animals | Proteins - metabolism | NF-kappa B - genetics | Endothelial Cells - cytology | Chemokine CXCL10 - secretion | Mice | Chemokine CXCL10 - metabolism | DNA-Binding Proteins - biosynthesis | Sarcoma, Kaposi - genetics | Cell proliferation | Cytokines | Transcription | Inflammation | regulatory proteins | IKK1 protein | Endothelial cells | FLICE-inhibitory protein | NF- Kappa B protein | Transcription activation | IP-10 protein | Chemokines | Tumors
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 69 - 73
Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation.... 
RHEUMATOID-ARTHRITIS | ACTIVATION | VARIANTS | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | RECEPTOR | TNFAIP3 | INHIBITOR | NF-KAPPA-B | ASSOCIATION | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - prevention & control | Cysteine Endopeptidases - metabolism | Receptors, Interleukin-1 - deficiency | Cysteine Endopeptidases - deficiency | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | DNA-Binding Proteins | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Interleukin-1 - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Arthritis, Rheumatoid - pathology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Mice | Arthritis, Rheumatoid - immunology | Prevention | Rheumatoid arthritis | Physiological aspects | NLRP3 | Properties | Macrophages | Risk factors | Proteins | Pathology | Dehydrogenases | Histopathology | Pathogenesis | Rodents | Protein expression | Nlrp3 | IL1R1 | caspase-1 | inflammasome | A20
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2011, Volume 12, Issue 9, pp. 834 - 843
In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to... 
DEUBIQUITINATING ENZYME | HTLV-I | INFLAMMATION | VIRUS TAX | T-CELL LEUKEMIA | DOWN-REGULATION | NF-KAPPA-B2 P100 | IMMUNOLOGY | TUMOR-SUPPRESSOR CYLD | MEDIATED PHOSPHORYLATION | EDITING ENZYME A20 | Escherichia coli | Humans | NF-kappa B - immunology | Neoplasm Proteins - immunology | Intracellular Signaling Peptides and Proteins - immunology | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | I-kappa B Kinase - pharmacology | Neoplasm Proteins - metabolism | Ubiquitin-Protein Ligases - immunology | Cysteine Endopeptidases - metabolism | Ubiquitination - drug effects | I-kappa B Kinase - metabolism | Gene Deletion | Cloning, Molecular | Interleukin-1 - immunology | Tumor Necrosis Factor-alpha - immunology | Tumor Necrosis Factor alpha-Induced Protein 3 | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Carrier Proteins - immunology | Recombinant Proteins - metabolism | Cell Line | Signal Transduction | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Antibodies, Phospho-Specific - pharmacology | Recombinant Proteins - genetics | I-kappa B Kinase - genetics | Immunity, Innate | Interleukin-1 - pharmacology | Carrier Proteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Recombinant Proteins - immunology | Antibodies, Phospho-Specific - immunology | Cysteine Endopeptidases - genetics | Fibroblasts - drug effects | Fibroblasts - immunology | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Cysteine Endopeptidases - immunology
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 01/2018, Volume 20, Issue 1, pp. 58 - 58
Ubiquitylation of the TNFR1 signalling complex (TNF-RSC) controls the activation of RIPK1, a kinase critically involved in mediating multiple TNF... 
CHRONIC INTESTINAL INFLAMMATION | NECROPTOSIS | INDUCED APOPTOSIS | LINEAR UBIQUITIN | PROGRAMMED NECROSIS | KINASE RIP | NF-KAPPA-B | CELL-DEATH | SIGNALING COMPLEX | A20 | CELL BIOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Phosphoproteins - metabolism | Genes, Lethal | Ubiquitination | HEK293 Cells | Fibroblasts - metabolism | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Phosphoproteins - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Fibroblasts - cytology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Cell Line, Transformed | Cellular signal transduction | Research | Gene expression | Tumor necrosis factor | Protein kinases | Tumor necrosis factor receptors | Ubiquitin | Signaling | Licenses | Activation | Lethality | Tumor necrosis factor-α | Kinases | Embryos | Apoptosis | Recruitment
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 08/2018, Volume 142, Issue 2, pp. 517 - 529
Anti-TNF inhibitors successfully improve the quality of life of patients with inflammatory disease. Unfortunately, not all patients respond to anti-TNF... 
TNF-α–induced protein 3 | TNF-α | IL-17A | inflammatory bowel disease | A20 | anti-TNF | RHEUMATOID-ARTHRITIS | TNF-alpha | KINASE-C-THETA | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | AUTOIMMUNE ENCEPHALOMYELITIS | INFLAMMATORY-BOWEL-DISEASE | ALLERGY | CELL ACTIVATION | TNF-alpha-induced protein 3 | NF-KAPPA-B | T-CELLS | GENOME-WIDE ASSOCIATION | TH17 CELLS | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Humans | Middle Aged | Male | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Molecular Targeted Therapy | Inflammatory Bowel Diseases - metabolism | CD4-Positive T-Lymphocytes - immunology | Young Adult | Protein Kinase C - metabolism | Anti-Inflammatory Agents - therapeutic use | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Inflammatory Bowel Diseases - drug therapy | Receptors, Tumor Necrosis Factor - metabolism | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-17 - metabolism | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Protein Kinase Inhibitors - therapeutic use | Adolescent | Aged | Protein Kinase Inhibitors - pharmacology | Biomarkers, Pharmacological - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Tumor necrosis factor receptors | Flow cytometry | Therapy | Protein kinase C | Inflammatory bowel diseases | Laboratories | Medical services | Fluorescence | Lymphocytes T | Feedback loops | Kinases | Western blotting | Gene sequencing | Proteins | Lymphocytes | Intestine | Inhibition | Immunological memory | Memory cells | Biological products | Psoriasis | Cytokines | Blood & organ donations | RNA-mediated interference | MAP kinase | siRNA | Tumor necrosis factor-α | Patients | CD4 antigen | Quality of life | Inflammatory bowel disease | Side effects | Molecular modelling | Inhibitors | Ribonucleic acids
Journal Article