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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 22, pp. E4380 - E4388
Journal Article
SCIENCE, ISSN 0036-8075, 02/2016, Volume 351, Issue 6275, pp. 871 - 875
p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for cancer drug development. We report cryo-electron microscopy... 
SYSTEM | DOMAIN | ANALOGS | P97/VCP | MULTIDISCIPLINARY SCIENCES | AAA-ATPASE | BINDING
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 9/2019, Volume 39, Issue 9, pp. 1836 - 1848
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection... 
AAA + ATPase | ATAD1 | stroke | neuroprotection | preconditioning
Journal Article
SCIENCE, ISSN 0036-8075, 08/2019, Volume 365, Issue 6452, pp. 502 - 502
The cellular machine Cdc48 functions in multiple biological pathways by segregating its protein substrates from a variety of stable environments such as... 
SYSTEM | MECHANISM | P97/VCP | MULTIDISCIPLINARY SCIENCES | AAA ATPASE | CRYO-EM STRUCTURE | BINDING | P97 | FEATURES
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 204, Issue 6, pp. 869 - 879
Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up mis-folded. Cells evolved protein quality... 
MISFOLDED GLYCOPROTEINS | RETICULUM-ASSOCIATED DEGRADATION | RETRO-TRANSLOCATION | HMG-COA REDUCTASE | AAA-ATPASE | MEMBRANE-PROTEIN | ENDOPLASMIC-RETICULUM | TO-CYTOSOL DISLOCATION | CLASS-I MOLECULES | UBIQUITIN-PROTEASOME PATHWAY | CELL BIOLOGY | Proteins | Control systems | Proteolysis | Quality control | Quality management | Reviews
Journal Article
SCIENCE, ISSN 0036-8075, 10/2014, Volume 346, Issue 6208, pp. 440 - 440
Chromosome replication is initiated by a universal mechanism in eukaryotic cells, involving the assembly and activation at replication origins of the CMG... 
REPLISOME | MULTIDISCIPLINARY SCIENCES | POLYMERASE ALPHA | AAA-ATPASE | DOUBLE-STRAND BREAKS | CHROMOSOME-REPLICATION | YEAST GENES | GENOME STABILITY | DVC1 C1ORF124 | EUKARYOTIC DNA | SACCHAROMYCES-CEREVISIAE
Journal Article
SCIENCE, ISSN 0036-8075, 08/2019, Volume 365, Issue 6452, pp. 462 - 462
The Cdc48 adenosine triphosphatase ( ATPase) ( p97 or valosin-containing protein in mammals) and its cofactor Ufd1/Npl4 extract polyubiquitinated proteins from... 
RECOGNITION | STABILITY | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | PROTEASOME | RESOLUTION | AAA-ATPASE | CRYO-EM STRUCTURE | PAGET-DISEASE | P97
Journal Article
by Zhang, GH and Zhu, QZ and Fu, G and Hou, JB and Hu, XS and Cao, JJ and Peng, W and Wang, XW and Chen, F and Cui, HJ
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 12/2019, Volume 121, Issue 12, pp. 1069 - 1078
BACKGROUND: Thyroid hormone receptor interactor 13 (TRIP13) is an AAA + ATPase that plays an important role in the mitotic checkpoint. TRIP13 is highly... 
FBXW7 EXPRESSION | ONCOLOGY | POOR-PROGNOSIS | AAA-ATPASE | TUMOR-SUPPRESSOR | RETROVIRUSES | CANCER
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2016, Volume 113, Issue 28, pp. 7816 - 7821
Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System (UPS). The 26S proteasome holocomplex consists of a core particle (CP)... 
REGULATORY PARTICLE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | UBIQUITIN RECEPTOR | proteostasis | SOFTWARE | 20S PROTEASOME | integrative modeling | AAA-ATPase | DEGRADATION | MOLECULAR-DYNAMICS SIMULATIONS | CRYO-EM STRUCTURE | DEUBIQUITINATION | cryo-electron microscopy | SUBUNIT
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2814 - 2829
Inhibitors of human p97 (also known as valosin-containing protein) have been actively pursued because of their potential therapeutic applications in cancer and... 
PHOSPHATE | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | PROTEIN | UBIQUITIN | REACTIVITY | VCP/P97 | BINDING | DERIVATIVES | AAA-ATPASE P97 | REVEALS
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 05/2017, Volume 19, Issue 5, pp. 468 - 468
Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase... 
MCM2-7 HELICASE | ACTIVATION | UBIQUITIN | COMPLEXES | AAA-ATPASE | FACTOR-1 FAF1 | DEGRADATION | CELL-CYCLE PROGRESSION | INHIBITOR | C. ELEGANS | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 46, pp. 12991 - 12996
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 18, pp. 3877 - 3883
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2008, Volume 12, Issue 6A, pp. 2511 - 2518
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2016, Volume 113, Issue 28, pp. 7816 - 7821
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 09/2019, Volume 476, Issue 18, pp. 2561 - 2577
Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep processes termed ER-associated degradation (ERAD). Valosin-containing... 
PROTEIN-KINASE-A | TRANSPORT | COMPLEX | UBIQUITIN | P97/VCP | BIOCHEMISTRY & MOLECULAR BIOLOGY | AAA-ATPASE | DVC1 C1ORF124 | BINDING | P97
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 07/2018, Volume 25, Issue 7, pp. 616 - 616
Many polyubiquitinated proteins are extracted from membranes or complexes by the conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal... 
SYSTEM | COMPLEX | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXCHANGE-MASS-SPECTROMETRY | BEAM-INDUCED MOTION | MODEL | P97 | CELL BIOLOGY | BIOPHYSICS | AAA-ATPASE | CRYO-EM STRUCTURE | DEUBIQUITINATION
Journal Article