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PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62667 - e62667
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase... 
SIGNAL-TRANSDUCTION PATHWAYS | PPAR-ALPHA | B TYPE-I | SCAVENGER RECEPTOR | REVERSE CHOLESTEROL TRANSPORT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | APOA-I | LIVER-X-RECEPTORS | E-DEFICIENT MICE | HIGH-DENSITY-LIPOPROTEIN | Cricetinae | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ras Proteins - metabolism | ATP Binding Cassette Transporter 1 - chemistry | Cholesterol - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Gene Expression Regulation - drug effects | Proteolysis - drug effects | ATP-Binding Cassette Transporters - chemistry | Animals | MAP Kinase Signaling System - drug effects | ATP-Binding Cassette Transporters - genetics | Protein Stability - drug effects | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | ATP Binding Cassette Transporter 1 - genetics | CHO Cells | Proteolysis | DNA polymerases | Cellular signal transduction | Blood lipids | Macrophages | Mitogens | Protein kinases | Cholesterol | Protein binding | Phosphorylation | H-Ras protein | RNA-directed DNA polymerase | Transcription | Syngeneic grafts | Liver | Gene regulation | Kinases | Cell surface | Protein turnover | K-Ras protein | Degradation | ABCA1 protein | Proteins | Signal transduction | Pathways | Rodents | Atherosclerosis | Cell cycle | Inhibition | Lipoproteins (high density) | Efflux | Liver X receptors | Extracellular signal-regulated kinase | MAP kinase | Ras protein | Gene expression | Apolipoproteins | Polymerase chain reaction | Signaling | Lipoproteins | Inhibitors | Protein kinase | Pharmacy | Cell lines | ATP-binding protein | Transduction | ATP | Transporter | ABC transporter | Kidney transplantation | Index Medicus | Reacció en cadena de la polimerasa | Colesterol | Proteïnes quinases
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17321 - 17326
Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been identified as a key protein in cholesterol metabolism through the... 
MicroRNA | Hepatocytes | Exons | Introns | HDL lipoproteins | Liver | Genes | Mice | Macrophages | Cholesterols | ABCA1 | Metabolic syndrome | Cholesterol efflux | Macrophage | HOMEOSTASIS | FATTY-ACID SYNTHESIS | liver | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | macrophage | metabolic syndrome | TANGIER-DISEASE | HOST GENES | EFFLUX | REVERSE CHOLESTEROL TRANSPORT | DENSITY-LIPOPROTEIN DEFICIENCY | cholesterol efflux | TRANSGENIC MICE | Cell Line | Cholesterol, HDL - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Cholesterol, HDL - genetics | Macrophages - metabolism | Sequence Alignment | Animals | ATP-Binding Cassette Transporters - genetics | Cattle | Base Sequence | Chickens | ATP-Binding Cassette Transporters - metabolism | Female | MicroRNAs - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Blood cholesterol | Low density lipoproteins | Biosynthesis | Research | Properties | Binding proteins | Proteins | Rodents | Ribonucleic acid--RNA | Metabolism | Gene expression | Binding sites | Cholesterol | Steroids | Index Medicus | Lipoproteins (low density) | Transcription factors | Data processing | Protein turnover | ABCA1 protein | Apolipoprotein A | Sterol regulatory element-binding protein | ATP-binding protein | miRNA | Lipid metabolism | Lipoproteins (high density) | Peritoneum | Biological Sciences
Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 09/2019, Volume 1864, Issue 9, pp. 1247 - 1257
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2017, Volume 31, Issue 6, pp. 2364 - 2379
Recently, we demonstrated that heat shock protein (HSP)-27 is protective against the development of experimental atherosclerosis, reducing plaque cholesterol... 
Toll-like receptors | NF-κB | Macrophages | Atherosclerosis | atherosclerosis | ATHEROSCLEROTIC LESION DEVELOPMENT | COLONY-STIMULATING FACTOR | DENDRITIC CELLS | INFLAMMATORY DISEASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLLATERAL GROWTH | CELL BIOLOGY | macrophages | NF-kappa B | RECEPTOR SIGNALING PATHWAY | ENDOTHELIAL-CELLS | BIOLOGY | MACROPHAGE BURDEN | E-DEFICIENT MICE | CORONARY-ARTERY-DISEASE | Cell Line | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Gene Expression Regulation - physiology | Toll-Like Receptor 4 - genetics | NF-kappa B - metabolism | Cholesterol - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - metabolism | Apolipoproteins E - metabolism | Toll-Like Receptor 4 - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | HSP27 Heat-Shock Proteins - genetics | Animals | NF-kappa B - genetics | Apolipoproteins E - genetics | HSP27 Heat-Shock Proteins - metabolism | Mice | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - genetics | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter 1 - genetics | Activation | Drug development | ABCA1 protein | Signal transduction | Cell activation | Developmental stages | Apolipoprotein E | Rodents | Colony-stimulating factor | Recombinant | Efflux | NF-κB protein | Granulocyte-macrophage colony-stimulating factor | Heat shock proteins | Pharmacology | Cholesterol | Signaling | Monocytes | Hsp27 protein | Arteriosclerosis | ATP-binding protein | Transport | Leukocytes (granulocytic) | Heat shock | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1324 - 1337
SIRT 6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic... 
atherosclerosis | foam cells | autophagy | cholesterol efflux | 6 | SIRT | SIRT6 | ACTIVATION | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | INDUCTION | PROTECTS | HYPERTROPHY | DEACETYLATION | METABOLISM | GENE-EXPRESSION | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Foam Cells - ultrastructure | Microtubule-Associated Proteins - metabolism | Humans | MicroRNAs - metabolism | Autophagy-Related Protein 5 - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - metabolism | Autophagy | Foam Cells - cytology | Recombinant Fusion Proteins - metabolism | ATP Binding Cassette Transporter 1 - metabolism | RNA Interference | Gene Expression Regulation, Developmental | Sirtuins - genetics | Foam Cells - metabolism | Macrophages - immunology | Recombinant Proteins - metabolism | Macrophages - ultrastructure | Microscopy, Electron, Transmission | Lysosome-Associated Membrane Glycoproteins - metabolism | Lipoproteins, LDL - adverse effects | Recombinant Proteins - chemistry | Macrophages - cytology | Cholesterol - metabolism | Macrophages - metabolism | Lipoproteins, LDL - antagonists & inhibitors | Autophagy-Related Protein 5 - metabolism | Cell Line, Tumor | Lysosome-Associated Membrane Glycoproteins - genetics | Luminescent Proteins - genetics | Foam Cells - immunology | Mutation | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - genetics | Sirtuins - antagonists & inhibitors | Sirtuins - metabolism | ATP Binding Cassette Transporter 1 - genetics | Amino Acid Substitution | Luminescent Proteins - metabolism | Diabetics | Macrophages | Low density lipoproteins | Cholesterol | Atherosclerosis | Lipoproteins (low density) | Diabetes mellitus | Lipids | Metabolism | Electron microscopy | ABCA1 protein | Transmission electron microscopy | Arteriosclerosis | ATP-binding protein | Lipid metabolism | Cardiovascular diseases | Phagocytosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0136895 - e0136895
Activation of apolipoprotein E receptor-2 (apoER2) and very low density lipoprotein receptor (VLDLR) inhibits foam cell formation. Reelin is a ligand of these... 
TANGIER-DISEASE | PROTEIN | FOAM CELL-FORMATION | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | FRAGMENT | BINDING | EXPRESSION | DEFICIENCY | APOLIPOPROTEIN-E | VLDL RECEPTOR | LDL-Receptor Related Proteins - metabolism | Nerve Tissue Proteins - secretion | Atherosclerosis - genetics | Humans | Culture Media, Conditioned - pharmacology | LDL-Receptor Related Proteins - genetics | ATP Binding Cassette Transporter 1 - metabolism | Extracellular Matrix Proteins - secretion | Nerve Tissue Proteins - chemistry | HEK293 Cells | Lipoproteins - metabolism | Serine Endopeptidases - genetics | Serine Endopeptidases - secretion | Binding Sites | Cell Line | Receptors, LDL - genetics | Extracellular Matrix Proteins - chemistry | Cell Adhesion Molecules, Neuronal - chemistry | Extracellular Matrix Proteins - genetics | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Cholesterol - metabolism | Nerve Tissue Proteins - genetics | Atherosclerosis - metabolism | Cell Adhesion Molecules, Neuronal - genetics | Cell Adhesion Molecules, Neuronal - secretion | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Macrophages - drug effects | Mice | Physiological aspects | Genetic aspects | Research | Macrophages | Apolipoproteins | Lipoproteins (low density) | Atherogenesis | Phosphorylation | Peptides | Lipids | Kinases | Cell surface | Reelin protein | Accumulation | ABCA1 protein | Proteins | Receptors | Cell activation | Apolipoprotein E | Atherosclerosis | Gangrene | Lipoprotein (low density) receptors | Physiology | ABC transporters | Lipid metabolism | Dihydrofolate reductase | Conditioning | Binding | Efflux | Immunoglobulins | Metabolism | Sp1 protein | Cholesterol | 1-Phosphatidylinositol 3-kinase | Lipoproteins | Receptor density | ATP-binding protein | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1566 - 1569
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2014, Volume 34, Issue 10, pp. 2261 - 2267
OBJECTIVE—Therapeutic interventions that increase plasma levels of high-density lipoproteins and apolipoprotein A-I (apoA-I) A-I, the major high-density... 
ACTIVATION | PROTEIN-KINASE | RECEPTOR | APOA-I | apolipoprotein A-I | FOXO1 | GLUCOSE-METABOLISM | CHOLESTEROL EFFLUX | PERIPHERAL VASCULAR DISEASE | diabetes mellitus, type 2 | HDL CHOLESTEROL | HEMATOLOGY | HIGH-DENSITY-LIPOPROTEINS | ABCA1 TRANSPORTER | Up-Regulation | Male | Insulin - biosynthesis | Adenylyl Cyclase Inhibitors | Insulin-Secreting Cells - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Time Factors | Forkhead Transcription Factors - metabolism | ATP-Binding Cassette Transporters - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Insulin Secretion | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Cyclic AMP-Dependent Protein Kinases - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Signal Transduction | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Rats | Scavenger Receptors, Class B - genetics | Adenylyl Cyclases - metabolism | Apolipoprotein A-I - metabolism | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Forkhead Box Protein O1 | Mice | Scavenger Receptors, Class B - metabolism | Insulin-Secreting Cells - enzymology | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145467 - e0145467
Alzheimer's disease (AD) is the major cause of dementia worldwide. The pharmacological activation of nuclear receptors (Liver X receptors: LXRs or Retinoid X... 
WILD-TYPE | AMYLOID BETA-PEPTIDE | ADULT NEUROGENESIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SUBVENTRICULAR ZONE | TRANSGENIC MODEL | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | APOLIPOPROTEIN-E | Benzoates - therapeutic use | Cerebral Cortex - pathology | tau Proteins - metabolism | Cognition Disorders - metabolism | Male | Hippocampus - drug effects | Orphan Nuclear Receptors - metabolism | Apolipoproteins E - metabolism | Excitatory Postsynaptic Potentials - drug effects | ATP Binding Cassette Transporter 1 - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Gliosis - pathology | Dentate Gyrus - drug effects | Long-Term Potentiation - drug effects | Liver X Receptors | Amyloid beta-Peptides - metabolism | Female | Cerebral Cortex - drug effects | Biomarkers - metabolism | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Dentate Gyrus - metabolism | Orphan Nuclear Receptors - agonists | Neural Stem Cells - drug effects | Alzheimer Disease - drug therapy | Mice, Transgenic | Nuclear Proteins - metabolism | Hippocampus - pathology | Cognition Disorders - drug therapy | Gliosis - complications | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Up-Regulation - drug effects | Hippocampus - metabolism | Cognition Disorders - complications | Animals | Alzheimer Disease - metabolism | Fluorescent Antibody Technique | Benzoates - pharmacology | Protein Biosynthesis - drug effects | Cell Proliferation - drug effects | Benzylamines - pharmacology | Benzylamines - therapeutic use | Dentate Gyrus - pathology | Neural Stem Cells - metabolism | Brain | Advertising executives | Cognition | Apolipoproteins | Alzheimer's disease | Liver | Amyloidogenesis | Peptides | Cognitive ability | Proteins | Receptors | Neurodegeneration | Physiology | Chemical synthesis | Neurodegenerative diseases | Cortex | Protein biosynthesis | Behavioral sciences | Metabolism | Retinoid X receptors | Nuclear receptors | Dentate gyrus | Gliosis | Molecular modelling | Tau protein | Protein synthesis | Stem cells | Ligands | ATP-binding protein | Hippocampus | Animal models | Cerebral cortex | Lipids | Kinases | Neurogenesis | ABCA1 protein | Reduction | Metabolites | Apolipoprotein E | Rodents | Dementia disorders | Liver X receptors | Neurons | Pharmacology | Cholesterol | Cortex (entorhinal) | Plasticity (synaptic) | Presenilin 1 | Laboratory animals | Alzheimers disease | Animal cognition | Index Medicus
Journal Article