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Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2015, Volume 5, Issue 5, pp. 390 - 401
Since the discovery that non-small cell lung cancer (NSCLC) is driven by epidermal growth factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors... 
Resistance | Mechanisms | TKIs | EGFR | TARGETED THERAPY | ACQUIRED-RESISTANCE | T790M MUTATION | GEFITINIB RESISTANCE | CELL LUNG-CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR RECEPTOR | ERLOTINIB RESISTANCE | PHARMACOLOGY & PHARMACY | INTEGRIN BETA1 | TUMOR-GROWTH | ALK, anaplastic lymphoma kinase | BH3, BCL2-homology domain 3 | PDGFRs, platelet-derived growth factor receptors | lymphoma-2 | PDGFs, platelet-derived growth factors | PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha | VEGFR, vascular endothelial growth factor receptor | RAF, rapidly accelerated fibrosarcoma | FGFs, fibroblast growth factors | BCL-2, B-cell CLL | IGFBPs, IGF-binding proteins | ERK1 | BIM, BCL2-like 11 | ABCC10, ATP binding cassette, sub-family C, member 10 | ABCC1, ATP binding cassette, sub-family C, member 1 | VEGF, vascular endothelial growth factor | TKs, tyrosine kinases | HER, human epidermal receptor | MEK, mitogen-activated protein kinase | EGFR, epidermal growth factor receptor | BRAF, v-RAF murine sarcoma viral oncogene homolog B1 | AXL, Anexelekto | AKT, protein kinase B | IL, interleukin | TKIs, tyrosine kinase inhibitors | RAS, rat sarcoma | RTK, tyrosine kinase receptor | MAPK, mitogen-activated protein kinase | FGFRs, fibroblast growth factor receptors | SOCS3, suppressor of cytokine signaling 3 | EMT, epithelial mesenchymal transition | IGF, insulin growth factor | Review | 2, extracellular signal-regulated kinases | EML4, echinoderm microtubule-associated protein-like 4 | ABCG2, ATP binding cassette, sub-family G, member 2 | ABCB1, ATP binding cassette, sub-family B, member 1 | BCL2L11 | IL-6R, IL-6 receptor | IGF-1R, IGF-1 receptor | SF, scatter factor | PI3K, phosphatidylinositol-3-kinase | CML, chronic myelogenous leukemia | EGFR-TKIs, epidermal growth factor receptor tyrosine kinase inhibitors | JAK, janus kinase | NSCLC, non-small cell lung cancer | ABC, ATP binding cassette | GAS6, growth-arrest-specific protein 6 | STAT, signal transducers and activators of transcription | EGFRvIII, EGFR variant III | CRKL, Crk-like protein | HGF, hepatocyte growth factor | PTEN, phosphatase and tensin homolog
Journal Article
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 06/2013, Volume 437, Issue 1, pp. 77 - 87
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2009, Volume 37, Issue 2, pp. 359 - 365
Sunitinib malate (Sutent, SU11248) is a small-molecule receptor tyrosine kinase inhibitor that inhibits cellular signaling of multiple targets such as the... 
CHRONIC MYELOGENOUS LEUKEMIA | HIGH-AFFINITY INTERACTION | MULTIDRUG TRANSPORTER | MEDIATED DRUG EFFLUX | MRP1 ABCC1 | HEMATOPOIETIC STEM-CELLS | DIFFERENTIAL IMMUNOREACTIVITY | PHARMACOLOGY & PHARMACY | ANTITUMOR-ACTIVITY | IMATINIB MESYLATE | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Hydrolysis - drug effects | Humans | Protein Conformation - drug effects | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | ATP-Binding Cassette Transporters - chemistry | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Biological Transport - drug effects | Photoaffinity Labels | Adenosine Triphosphatases - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Neoplasm Proteins - chemistry | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | ATP-Binding Cassette Transporters - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Benzamides | Antineoplastic Agents, Phytogenic - pharmacology | Cell Line, Transformed | ATP-Binding Cassette Transporters - antagonists & inhibitors
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 01/2017, Volume 1859, Issue 1, pp. 69 - 79
Multidrug resistance (MDR) is the main cause of diminished success in cancer chemotherapy. ABC transport proteins are considered to be one important factor of... 
MRP1 | ABCC1 | Transport activation | Flux ratio | Activator | ABC transporter | GLUTATHIONE TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | P-GLYCOPROTEIN | SUBSTRATE-SPECIFICITY | IN-VITRO | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | CYSTEINE SUBSTITUTIONS | TRANSPORT ACTIVITY | BIOLOGICAL EVALUATION | SELECTIVE INHIBITORS | PHASE-I | Pyrimidines - chemical synthesis | Drug Resistance, Multiple - drug effects | Fluoresceins - metabolism | Humans | Daunorubicin - pharmacology | Fluorescent Dyes - metabolism | Structure-Activity Relationship | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | ATP Binding Cassette Transporter, Sub-Family B - agonists | Madin Darby Canine Kidney Cells | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Purines - chemical synthesis | Gene Expression | Drug Resistance, Multiple - genetics | Purines - pharmacology | Pyrimidines - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - agonists | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Neoplasm Proteins - agonists | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Multidrug Resistance-Associated Proteins - agonists | Kinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Alkaloids | Drug resistance in microorganisms | Chemotherapy | Anthracyclines | Carrier proteins | Lung cancer | Cancer | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2009, Volume 37, Issue 7, pp. 1411 - 1420
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2017, Volume 45, Issue 11, pp. 1166 - 1177
Journal Article
Oncology Reports, ISSN 1021-335X, 11/2012, Volume 28, Issue 5, pp. 1681 - 1686
Multidrug resistance is one of the major causes limiting the efficacy of chemotherapeutic agents to control esophageal cancer. Herein, we investigated that the... 
Multidrug-resistant | Oesophageal squamous carcinoma | Multidrug resistance-associated protein 1 | Tetrandrine | CANCER-CELLS | MRP1 | TRANSPORTER | oesophageal squamous carcinoma | multidrug resistance-associated protein 1 | DAUNORUBICIN | CHEMOTHERAPY | multidrug-resistant | REVERSAL | FANGCHINOLINE | ONCOLOGY | LEUKEMIA | tetrandrine | EXPRESSION | MRP1/ABCC1 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Drugs, Chinese Herbal - pharmacology | RNA, Messenger - metabolism | Esophageal Neoplasms - pathology | ATP-Binding Cassette Transporters - genetics | Esophageal Neoplasms - metabolism | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Benzylisoquinolines - pharmacology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis | Cisplatin - pharmacology | ATP-Binding Cassette Transporters - biosynthesis | Drug Resistance, Neoplasm - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Cell Proliferation - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Apoptosis
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19329
One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously,... 
CELLS | HUMAN P-GLYCOPROTEIN | MRP1 ABCC1 | BIOLOGY | SUBFAMILY-B MEMBER-1 | REVERSES MULTIDRUG-RESISTANCE | MOLECULAR-BASIS | BINDING | CANCER | MODULATION | CHEMOTHERAPY | Phosphodiesterase 5 Inhibitors - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Imidazoles - chemistry | Piperazines - metabolism | Carbolines - metabolism | Piperazines - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Sulfones - pharmacology | Carbolines - chemistry | Sulfones - chemistry | Phosphodiesterase 5 Inhibitors - metabolism | Triazines - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Imidazoles - metabolism | Triazines - metabolism | Triazines - pharmacology | KB Cells | Adenosine Triphosphatases - metabolism | Models, Molecular | Sulfones - metabolism | Imidazoles - pharmacology | Piperazines - pharmacology | Adenosine Triphosphatases - antagonists & inhibitors | Tadalafil | Vardenafil Dihydrochloride | Adenosine Triphosphatases - chemistry | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Carbolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Chemotherapy | Drug therapy | Adenosine triphosphatase | Cancer | Drugs | Biotechnology | Laboratories | Toxicity | Leukemia | Brain cancer | Clinical trials | Cytotoxicity | Oncology | Biology | Metastasis | Drug resistance | Kinases | Cancer therapies | Proteins | Antitumor agents | Paclitaxel | P-Glycoprotein | Pharmaceutical sciences | Phosphodiesterase | Efflux | Medical research | Incubation | Multidrug resistance | Glycoprotein | Glycoproteins | Permeability | Substrates | Brain research | Inhibitors | Pharmacy | Cell lines | Transporter | Apoptosis
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 11/2007, Volume 60, Issue 6, pp. 789 - 797
ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-related protein 1... 
Growth inhibition assay | Biomedicine | P-glycoprotein/ABCB1 | Oncology | Cancer Research | Pharmacology/Toxicology | BCRP/ABCG2 | Flavonoid | MRP1/ABCC1 | P-GLYCOPROTEIN INHIBITOR | CELLS | (ABCG2)-MEDIATED TRANSPORT | growth inhibition assay | COMBINATION | GENISTEIN | REVERSAL | ONCOLOGY | VALSPODAR | VINCRISTINE | PHARMACOLOGY & PHARMACY | flavonoid | MULTIDRUG-RESISTANCE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - antagonists & inhibitors | Structure-Activity Relationship | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Antineoplastic Agents, Hormonal - pharmacokinetics | Dose-Response Relationship, Drug | Biological Transport | Flavones - administration & dosage | ATP-Binding Cassette Transporters - metabolism | Flavonoids - administration & dosage | Inhibitory Concentration 50 | Flavonoids - pharmacology | Flavones - pharmacology | Multidrug Resistance-Associated Proteins - drug effects | K562 Cells | Topotecan - pharmacokinetics | Cell Line, Tumor | Cell Proliferation - drug effects | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Care and treatment | Breast cancer | Drug resistance | Drug therapy | Cancer | Isoflavones
Journal Article