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International Journal of Molecular Sciences, ISSN 1422-0067, 07/2019, Volume 20, Issue 15, p. 3700
Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in... 
Index Medicus | neuroblastoma | ATM | DNA-PK | checkpoint abrogation | CHK1
Journal Article
2013, Routledge studies in religion, ISBN 9780203096208, Volume 22, x, 287
This book examines in detail the concept of "abrogation" in the Qur'an, which has played a major role in the development of Islamic law and has implications... 
Islamic law | Interpretation and construction | Qurʼan Abrogator and abrogated verses | Electronic books
Book
2013, Studies in Postwar American Political Development, ISBN 0199928991, xx, 275
When we think of a social movement, we usually picture poor people taking to the streets. But ever since the beginning of the twentieth century, a small... 
Rich people | Repeal of legislation | Tax credits | Income tax | Social movements | politics | United States
Book
2016, ISBN 1137340355, x, 302
"With over 7000 languages in use world-wide, how do some languages acquire hegemonic status? What role does prize-winning fiction play in creating linguistic... 
LITERARY CRITICISM / Asian / Indic | Multilingualism and literature | Linguistic analysis (Linguistics) | Oriental literature | LITERARY COLLECTIONS / Asian | History and criticism | Frames (Linguistics) | LANGUAGE ARTS & DISCIPLINES / Linguistics / General | Fiction
Book
CHEMICAL RESEARCH IN TOXICOLOGY, ISSN 0893-228X, 06/2019, Volume 32, Issue 6, pp. 1123 - 1133
Nitrogen mustard, mechlorethamine (bis(2-chloroethyl)methylamine; HN2), and sulfur mustard are potent vesicants that modify and disrupt cellular... 
CHEMISTRY, MEDICINAL | PROTEIN CROSS-LINKING | PHOSPHORYLATION | NITROGEN-MUSTARD | MECHANISMS | TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | REPAIR | INHIBITION | REDUCTION | ABROGATION | CHECKPOINT | TOXICOLOGY
Journal Article
Cancer Biology and Therapy, ISSN 1538-4047, 04/2010, Volume 9, Issue 7, pp. 514 - 522
MK-1775 is a potent and selective small molecule Wee1 inhibitor. Previously we have shown that it abrogated DNA damaged checkpoints induced by gemcitabine,... 
Checkpoint | DNA-damaging agents | Wee1 | Kinase inhibitor | 5-FU | MK-1775 | checkpoint | PHOSPHORYLATION | THYMIDYLATE SYNTHASE | KINASE | SENSITIVITY | MECHANISMS | G CHECKPOINT | kinase inhibitor | CHK1 | ONCOLOGY | CANCER CELL-LINES | CHECKPOINT ABROGATION | CYCLE
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2018, Volume 17, Issue 9, pp. 1076 - 1086
Small molecule inhibitors of the checkpoint proteins CHK1 and WEE1 are currently in clinical development in combination with the antimetabolite gemcitabine. It... 
AZD1775 | WEE1 | pancreatic cancer | gemcitabine | CHK1 | MK8776 | ADVANCED SOLID TUMORS | FORK | MONOTHERAPY | KINASE | COMBINATION | S-PHASE CHECKPOINT | H2AX PHOSPHORYLATION | CELL BIOLOGY | ABROGATION | HOMOLOGOUS RECOMBINATION
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2008, Volume 68, Issue 18, pp. 7570 - 7578
Radiotherapy combined with chemotherapy is the treatment of choice for glioblastoma and locally advanced lung cancer, but radioresistance of these two types of... 
SIGNAL-TRANSDUCTION | APOPTOSIS | ACTIVATION | FACTORS TRAFS | ONCOLOGY | GENE-EXPRESSION PATTERNS | E3 UBIQUITIN LIGASES | KINASE INHIBITOR | IONIZING-RADIATION | NF-KAPPA-B | CHECKPOINT ABROGATION
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 06/2019, Volume 14, Issue 6, pp. 1032 - 1045
Introduction: Platinum-based chemotherapy remains the standard treatment for patients with SCLC, but the benefit of the treatment is often hampered by rapid... 
SCLC | Caspase 2 | Checkpoint kinase 1 | Cisplatin | E2F transcription factor 1 | DNA-DAMAGE | CHK1 INHIBITORS | ANTITUMOR-ACTIVITY | G CHECKPOINT | S-PHASE CHECKPOINT | P53 | LUNG-CANCER | ONCOLOGY | RESPIRATORY SYSTEM | ABROGATION | E2F1 | ATR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 8, pp. 3336 - 3341
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 01/2003, Volume 63, Issue 1, pp. 31 - 35
In response to DNA damage, cells arrest progression through the cell cycle at either G(1), S, or G(2). We have reported that UCN-01 (7-hydroxy-staurosporine)... 
PATHWAYS | APOPTOSIS | ACTIVATION | ONCOLOGY | PHOSPHORYLATION | 7-HYDROXYSTAUROSPORINE UCN-01 | ABROGATION | ENHANCEMENT | CAFFEINE | RADIOSENSITIZING AGENT | CYTOTOXICITY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2011, Volume 17, Issue 9, pp. 2799 - 2806
Journal Article
Cancer Research, ISSN 0008-5472, 09/2013, Volume 73, Issue 17, pp. 5336 - 5346
Journal Article
Cell Cycle, ISSN 1538-4101, 03/2018, Volume 17, Issue 6, pp. 671 - 680
The increasing resistance of nasopharyngeal carcinoma to irradiation makes the exploration of effective radiosensitizers necessary. Tetrandrine is known to be... 
Tetrandrine | nasopharyngeal carcinoma | CDC25C/CDK1/cyclin B1 pathway | G2/M arrest | radiosensitivity | MECHANISM | DNA-DAMAGE REPAIR | PHOSPHORYLATION | CDC25C | cyclin B1 pathway | RADIATION | CELL BIOLOGY | ABROGATION | CDK1 | RESISTANCE | CHECKPOINT | M arrest | RADIOTHERAPY | CONCURRENT CHEMORADIOTHERAPY | CYCLE
Journal Article
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