X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
abt-263 (123) 123
apoptosis (108) 108
index medicus (105) 105
humans (94) 94
oncology (63) 63
sulfonamides - pharmacology (59) 59
cell line, tumor (52) 52
cancer (50) 50
bcl-2 (46) 46
aniline compounds - pharmacology (45) 45
apoptosis - drug effects (44) 44
proteins (43) 43
antineoplastic agents - pharmacology (40) 40
proto-oncogene proteins c-bcl-2 - antagonists & inhibitors (39) 39
animals (37) 37
abt-737 (35) 35
mcl-1 (34) 34
proto-oncogene proteins c-bcl-2 - metabolism (33) 33
article (29) 29
inhibitor (29) 29
cell biology (27) 27
chronic lymphocytic-leukemia (26) 26
expression (26) 26
mice (26) 26
navitoclax (26) 26
potent (23) 23
resistance (23) 23
drug synergism (22) 22
proto-oncogene proteins c-bcl-2 - genetics (22) 22
chemotherapy (21) 21
leukemia (21) 21
sulfonamides - administration & dosage (20) 20
pharmacology & pharmacy (19) 19
sensitivity (18) 18
analysis (17) 17
bcl-2 protein (17) 17
bcl-xl (17) 17
biochemistry & molecular biology (17) 17
cell death (17) 17
female (17) 17
research (17) 17
xenograft model antitumor assays (17) 17
navitoclax abt-263 (16) 16
abt-199 (15) 15
biphenyl compounds - pharmacology (15) 15
death (15) 15
mitochondria (15) 15
piperazines - pharmacology (15) 15
tumors (15) 15
aniline compounds - administration & dosage (14) 14
cell survival - drug effects (14) 14
nitrophenols - pharmacology (14) 14
antineoplastic agents - therapeutic use (13) 13
bcl-2 family (13) 13
bcl-x protein - metabolism (13) 13
bh3 mimetic abt-737 (13) 13
hematology (13) 13
in-vitro (13) 13
myeloid cell leukemia sequence 1 protein - antagonists & inhibitors (13) 13
sulfonamides - therapeutic use (13) 13
apoptosis regulatory proteins - metabolism (12) 12
care and treatment (12) 12
dose-response relationship, drug (12) 12
drug resistance, neoplasm - drug effects (12) 12
activation (11) 11
bcl-x protein - antagonists & inhibitors (11) 11
blotting, western (11) 11
chemistry, medicinal (11) 11
inhibitors (11) 11
lung cancer (11) 11
myeloid cell leukemia sequence 1 protein - metabolism (11) 11
neoplasms - drug therapy (11) 11
aniline compounds - therapeutic use (10) 10
antimitotic agents (10) 10
antineoplastic agents (10) 10
antineoplastic combined chemotherapy protocols - pharmacology (10) 10
bcl-2 family inhibitor (10) 10
bcl-x protein (10) 10
bridged bicyclo compounds, heterocyclic - pharmacology (10) 10
cancer research (10) 10
cell-death (10) 10
down-regulation (10) 10
family (10) 10
lymphomas (10) 10
male (10) 10
proto-oncogene proteins - metabolism (10) 10
survival (10) 10
abt‐263 (9) 9
bim (9) 9
breast cancer (9) 9
cancer cells (9) 9
cancer therapies (9) 9
cells (9) 9
gene expression (9) 9
inhibition (9) 9
physiological aspects (9) 9
antitumor-activity (8) 8
apoptosis - genetics (8) 8
bax (8) 8
bcl-2-like protein 11 (8) 8
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


BLOOD, ISSN 0006-4971, 02/2012, Volume 119, Issue 5, pp. 1321 - 1322
Journal Article
Oncotarget, ISSN 1949-2553, 09/2019, Volume 10, Issue 52
Journal Article
BLOOD, ISSN 0006-4971, 06/2011, Volume 117, Issue 26, pp. 7145 - 7154
Apoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen... 
CELLS | BCL-2 PROTEIN FAMILY | MITOCHONDRIA | ABT-737 | CHRONIC LYMPHOCYTIC-LEUKEMIA | DEATH | CASPASE | ANTITUMOR-ACTIVITY | ABT-263 | HEMATOLOGY | CANCER-THERAPY
Journal Article
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 12/2013, Volume 12, Issue 12
Apigenin is an edible plant-derived flavonoid that shows modest anti-tumor activities in vitro and in vivo . Apigenin treatment resulted in cell growth arrest... 
apigenin | Mcl-1 | AKT | ABT-263 | ERK
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 21, pp. 5458 - 5470
Purpose: Clinically available BH3 mimetic drugs targeting BCLXL and/or BCL2 (navitoclax and venetoclax, respectively) are effective in some hematologic... 
BREAST-CANCER | PROTEIN | SOLID TUMORS | ONCOLOGY | SENSITIVITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | ACUTE MYELOID-LEUKEMIA | BH3 MIMETIC ABT-737 | CELL-SURVIVAL | ABT-263 | NAVITOCLAX
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2011, Volume 10, Issue 12, pp. 2340 - 2349
The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also contribute to chemoresistance. The Bcl-2 family of prosurvival... 
BREAST-CANCER | APOPTOSIS | ONCOLOGY | BCL-2 FAMILY INHIBITOR | PROSTATE-CANCER | RESISTANCE | ABT-737 | SENSITIVITY | RECEPTOR GENE | ABT-263 | CANCER CELL-LINES
Journal Article
by Lin, QH and Que, FC and Gu, CP and Zhong, DS and Zhou, D and Kong, Y and Yu, L and Liu, SW
ACTA PHARMACOLOGICA SINICA, ISSN 1671-4083, 12/2017, Volume 38, Issue 12, pp. 1632 - 1641
Both the anti-and pro-apoptotic members of the Bcl-2 family are regulated by a conserved Bcl-2 homology (BH3) domain. ABT-263 (Navitoclax), a novel BH3 mimetic... 
cyclin D1 and phospho-Rb (Ser780) | autophagy | BCL-2 FAMILY PROTEINS | human esophageal cancer cells | apoptosis | LC3-II | CHEMISTRY, MULTIDISCIPLINARY | G/G phase arrest | BH3 MIMETIC ABT-263 | PHARMACOLOGY & PHARMACY | ABT-263 | INHIBITOR | p21(Waf1/Cip1) | CYCLE
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 03/2019, Volume 25, Issue 5, pp. 1664 - 1675
Purpose: It was recently demonstrated that the EWSR1-FLI1 t(11; 22)(q24; 12) translocation contributes to the hypersensitivity of Ewing sarcoma to PARP... 
CANCER-CELLS | LUNG-CANCER | ONCOLOGY | INDUCED APOPTOSIS | SARCOMA | BIM | TRANSCRIPTION | FUSION PROTEIN | SENSITIVITY | DOUBLE-STRAND BREAKS | ABT-263
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 03/2015, Volume 7, Issue 279, pp. 279ra40 - 279ra40
Journal Article
CELL DEATH AND DIFFERENTIATION, ISSN 1350-9047, 01/2018, Volume 25, Issue 1, pp. 56 - 64
Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-family interactions makes it challenging to predict cell fate via... 
CYTOCHROME-C | ANTI-APOPTOTIC MCL-1 | FAMILY-MEMBER BOK | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY | MITOCHONDRIAL DYSFUNCTION | BH3 MIMETIC ABT-737 | ANTIAPOPTOTIC BCL-2 | CELL-DEATH | NAVITOCLAX ABT-263 | CELL BIOLOGY | Proteins | Inhibitors | Cell fate | Addiction | Bcl-2 protein | Molecular biology | Cancer | Apoptosis | Anticancer properties | Review
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 3, pp. 362 - 675
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 1, pp. 15 - 22
Bcl-2 family proteins play an important role in regulation of the cell survival and death. The inhibition of the anti-apoptotic proteins of Bcl-2 family leads... 
Bcl-2 | Virtual screening | NSCLC | Autophagy | BH3 mimetics | Apoptosis | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BAX | NAVITOCLAX ABT-263 | Proteins | Clathrate compounds | Lung cancer, Non-small cell | Leukemia
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 1, pp. 312 - 324
Purpose: Effective targeted therapies are lacking for refractory and relapsed T-cell acute lymphoblastic leukemia (T-ALL). Suppression of the NOTCH pathway... 
TARGET | BCL-2 | LYMPHOMA-CELLS | INHIBITION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | MTOR PATHWAY | SENSITIVITY | BH3 MIMETIC ABT-737 | ACTIVATING MUTATIONS | TRANSLATIONAL CONTROL | leukemia | targeted therapy | NOTCH1 | MCL-1 | mTOR | GSI | ABT-263
Journal Article
Aging Cell, ISSN 1474-9718, 06/2016, Volume 15, Issue 3, pp. 428 - 435
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 2011, Volume 15, Issue 4, pp. 475 - 481
Journal Article
BMC Research Notes, ISSN 1756-0500, 03/2018, Volume 11, Issue 1, pp. 197 - 7
There are number of studies which report that BCL-2 anti-apoptotic proteins (e.g. BCL-2, BCL-XL, and MCL-1) are highly expressed in cervical cancer tissues... 
A-1210477 | BH3-mimetic | ABT-263 | Cervical cancer
Journal Article
by Luan, SL and Ge, Q and Chen, YD and Dai, MY and Yang, JY and Li, K and Liu, D and Zhao, LX
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2017, Volume 27, Issue 9, pp. 1943 - 1948
Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. We discovered LSL-A6... 
Bcl-2 | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | COMBINATION | Mcl-1 | POTENT | Structure-based design | VENETOCLAX | RESISTANCE | LEUKEMIA | ABT-263 | EXPRESSION | ABT-199 | Apoptosis
Journal Article