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Clinical Cancer Research, ISSN 1078-0432, 09/2013, Volume 19, Issue 18, pp. 5003 - 5015
Purpose: PARP1/2 inhibitors are a class of anticancer agents that target tumor-specific defects in DNA repair. Here, we describe BMN 673, a novel, highly... 
THERAPY | ONCOLOGY | MUTANT-CELLS | ABT-888 | SENSITIVITY | COMBINATION | TUMORS | CYTOTOXICITY | DAMAGE | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | TEMOZOLOMIDE
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 11/2015, Volume 13, Issue 11, pp. 1465 - 1477
Poly(ADP-ribose) polymerases (PARP1, -2, and -3) play important roles in DNA damage repair. As such, a number of PARP inhibitors are undergoing clinical... 
REPAIR | GLIOBLASTOMA | ONCOLOGY | STRUCTURAL BASIS | DNA-DAMAGE | ABT-888 | COMBINATION | TUMORS | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | BMN 673 | TEMOZOLOMIDE | CELL BIOLOGY
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 04/2019, Volume 84, Issue 8, pp. 4837 - 4845
(R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which... 
ASYMMETRIC-SYNTHESIS | ABT-888 | CHEMISTRY, ORGANIC | ALPHA-AMINO-ACIDS | N-ALKYLATION | DERIVATIVES | DISCOVERY
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 496 - 505
Purpose: This study examined safety, pharmacokinetics, and efficacy of veliparib, a PARP inhibitor, combined with carboplatin and etoposide in patients with... 
TRIAL | SINGLE-AGENT | GERMLINE BRCA1 | ONCOLOGY | ABT-888 | PLUS CARBOPLATIN | OVARIAN-CANCER | DNA-REPAIR | COMBINATION | CHEMOTHERAPY | PARP INHIBITOR VELIPARIB
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 02/2019, Volume 17, Issue 2, pp. 409 - 419
PARP inhibitors have recently been approved as monotherapies for the treatment of recurrent ovarian cancer and metastatic BRCA-associated breast cancer, and... 
DOSE-ESCALATION | OLAPARIB | POLY(ADP-RIBOSE) | EFFICACY | ONCOLOGY | MUTATION CARRIERS | VELIPARIB ABT-888 | OVARIAN-CANCER | COMBINATION | PHASE-I | BMN 673 | CELL BIOLOGY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2018, Volume 24, Issue 20, pp. 5143 - 5152
Purpose: Small cell lung cancer (SCLC) is an aggressive malignancy with a critical need for novel therapies. Our goal was to determine whether PARP inhibition... 
VELIPARIB | IN-VITRO | THERAPY | CISPLATIN | ONCOLOGY | DNA | ABT-888 | BIOLOGY | RADIATION | THORACIC RADIOTHERAPY | PARP INHIBITOR | Radiation Therapy | Radiosensitization | Poly(ADP-Ribose) Polymerase | PARP Trapping | Small Cell Lung Cancer
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 07/2018, Volume 16, Issue 7, pp. 1092 - 1102
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2010, Volume 53, Issue 8, pp. 3142 - 3153
We have developed a series of phenylpyrrolidine- and phenylpiperidine-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase (PARP) inhibitors with... 
CHEMISTRY, MEDICINAL | MODELS | ADP-RIBOSE POLYMERASE | DOXORUBICIN | ABT-888 | AGENTS | CANCER-THERAPY | DISCOVERY | PARP INHIBITOR
Journal Article
Journal Article
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 17, pp. 10242 - 10251
Veliparib (ABT-888), which can inhibit cancer growth by blocking DNA base excision repair, is one of several recently developed oral inhibitors of... 
Journal Article
Acta neuropathologica communications, ISSN 2051-5960, 08/2018, Volume 6, Issue 1, pp. 84 - 15
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 03/2018, Volume 148, Issue 3, pp. 507 - 514
Determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of veliparib combined with carboplatin and gemcitabine in patients with... 
Phase I | BRCA1/2 mutations | Veliparib | PARP inhibitor | Ovarian cancer | INTERGROUP TRIAL | FALLOPIAN-TUBE | BRCA 1/2 mutations | CHEMOTHERAPY | OBSTETRICS & GYNECOLOGY | CELL LUNG-CANCER | BREAST-CANCER | RIBOSYLATION | GERMLINE BRCA1 | ONCOLOGY | ABT-888 | RECURRENT EPITHELIAL OVARIAN | PRIMARY PERITONEAL | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 2, pp. 510 - 523
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2019, Volume 120, Issue 2, pp. 183 - 189
BACKGROUND: Metastatic colorectal cancer (mCRC) has low survival rates. We assessed if addition of veliparib, concurrent to FOLFIRI, improves survival in... 
TRIAL | 1ST-LINE TREATMENT | POLY(ADP-RIBOSE) POLYMERASE | OLAPARIB | REPAIR | ONCOLOGY | ABT-888 | IRINOTECAN | OPEN-LABEL | FLUOROURACIL | INHIBITOR | Randomization | Anemia | Colorectal carcinoma | Colorectal cancer | Metastasis | Survival | Patients | Neutropenia | Cancer | Bevacizumab | Metastases | Phase II trials | Chemotherapy
Journal Article
Neurochemistry International, ISSN 0197-0186, 10/2019, Volume 129, p. 104497
Chronic alcoholism promotes brain damage that impairs memory and cognition. High binge alcohol levels in adult rats also cause substantial neurodamage to... 
Alcohol | Neurodegeneration | Cytosolic phospholipase A2 | Poly(ADP-Ribose) polymerase | Veliparib | DEMENTIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMERASE | RECEPTOR | MODEL | NEUROSCIENCES | Poly(ADF-Ribose) polymerase | INTOXICATION | SLICE CULTURES | ABT-888 | ETHANOL | NEUROPATHOLOGY
Journal Article