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Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 9/2016, Volume 22, Issue 18, pp. 4698 - 4711
Journal Article
Aging, ISSN 1945-4589, 2016, Volume 8, Issue 9, pp. 1830 - 1831
Journal Article
Journal Article
Molecular Oncology, ISSN 1574-7891, 04/2019, Volume 13, Issue 4, pp. 738 - 756
Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that... 
ABT263 | endometrial cancer | cell death | FGFR2 inhibitor | BGJ398 | BIM | DOVITINIB TKI258 | AUTOPHAGY | ANTITUMOR-ACTIVITY | IN-VITRO | AMPLIFICATION | PHARMACOKINETICS | ONCOLOGY | GROWTH | EXPRESSION | PROMOTES
Journal Article
AGING CELL, ISSN 1474-9726, 08/2017, Volume 16, Issue 4, pp. 693 - 703
Age-related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in... 
LIFE-SPAN | OSTEOBLAST DIFFERENTIATION | DISTINCT | ABT263 | GATA4 | osteoporosis | CELLULAR SENESCENCE | p21 | MESENCHYMAL STEM-CELLS | p53 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | NF-kappa B | GROWTH ARREST | MICE | osteoblasts | BONE | IONIZING-RADIATION
Journal Article
Aging Cell, ISSN 1474-9718, 08/2017, Volume 16, Issue 4, pp. 693 - 703
Summary Age‐related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a... 
NF‐κB | ABT263 | GATA4 | osteoblasts | osteoporosis | p21 | p53 | NF-κB | Bone and Bones - pathology | Male | NF-kappa B - metabolism | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Aging - genetics | Osteoporosis - metabolism | Bone and Bones - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Osteoporosis - genetics | Cell Differentiation | Genes, Reporter | Osteogenesis - genetics | Mesenchymal Stromal Cells - drug effects | Osteoclasts - pathology | Aniline Compounds - pharmacology | GATA4 Transcription Factor - metabolism | Signal Transduction | Osteoblasts - drug effects | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Mesenchymal Stromal Cells - metabolism | GATA4 Transcription Factor - genetics | Mice, Transgenic | Sulfonamides - pharmacology | Osteoclasts - metabolism | G1 Phase Cell Cycle Checkpoints - genetics | Aging - pathology | Osteoblasts - pathology | Animals | Histones - genetics | NF-kappa B - genetics | Osteoporosis - pathology | Sp7 Transcription Factor - genetics | Sp7 Transcription Factor - metabolism | Luminescent Proteins - genetics | Mice | DNA Damage | Histones - metabolism | Mesenchymal Stromal Cells - pathology | Primary Cell Culture | Osteoblasts - metabolism | Osteoclasts - drug effects | Aging - metabolism | Luminescent Proteins - metabolism | Tumor proteins | DNA damage | DNA | Osteoprogenitor cells | GTP-binding protein | NF-κB protein | Phosphorylation | Senescence | Mesenchyme | Cytokines | p53 Protein | Osteoblasts | Bone resorption | Bone growth | Cyclin-dependent kinase inhibitor p21 | Bone mass | Stromal cells | Rodents | Cell cycle | Bone marrow | Bone loss | Bone (cortical) | Bone matrix | Age | Osteogenesis | Original
Journal Article
by Wang, GH and Huang, Y and Wu, ZP and Zhao, CM and Cong, H and Ju, SQ and Wang, XD
BIOSCIENCE REPORTS, ISSN 0144-8463, 03/2019, Volume 39, Issue 3
Significant challenges to develop selective and effective pharmacological inhibitors for important oncoproteins like RAS continue impeding the success to treat... 
APOPTOSIS | ONCOGENE | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | SYNERGY | SYNTHETIC LETHAL INTERACTION | EXPRESSION | REVEALS | CELL BIOLOGY | Wnt protein | Colorectal cancer | AKT protein | Pharmacology | β-catenin | Synergistic effects | Refractory materials | Colon cancer | Addiction | Combined treatment | Colon | Mutation | Apoptosis | Cancer
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 34, pp. 36456 - 36471
Glioblastoma is the most frequent primary brain tumor in adults. Current therapeutic options are sparse and the prognosis of patients suffering from this... 
ABT263 | TIC10/ONC201 | Apoptotic resistance | Multi-targeting | Glioblastoma | INDUCED APOPTOSIS | USP9X | ANTICANCER AGENT | BCL-2 FAMILY PROTEINS | DOWN-REGULATION | SENSITIVITY | TEMOZOLOMIDE | CELL BIOLOGY | CELL LUNG-CANCER | glioblastoma | multi-targeting | SMALL-MOLECULE ONC201/TIC10 | apoptotic resistance | ABT-737 RESISTANCE
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2012, Volume 48, Issue 16, pp. 3093 - 3103
Journal Article
Journal Article
ONCOTARGET, 06/2015, Volume 6, Issue 16, pp. 14507 - 14521
Despite great efforts taken to advance therapeutic measures for patients with glioblastoma, the clinical prognosis remains grim. The antiapoptotic Bcl-2 family... 
CANCER-CELLS | BH3-mimetic | ANTAGONIST | GX15-070 | MCL-1 | ABT263 | DOWN-REGULATION | PHASE-II | BH3 MIMETIC ABT-737 | OBATOCLAX GX15-070 | TEMOZOLOMIDE | CELL BIOLOGY | TRIAL | BCL-2 | glioblastoma | apoptotic resistance
Journal Article
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