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accelerated blood clearance (334) 334
humans (333) 333
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Small (Weinheim an der Bergstrasse, Germany), ISSN 1613-6810, 2015, Volume 11, Issue 46, pp. 6225 - 6236
Journal Article
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 3, pp. 417 - 424
Journal Article
Biomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 17, pp. 4757 - 4763
Journal Article
Pharmaceutical research, ISSN 1573-904X, 2012, Volume 30, Issue 4, pp. 985 - 995
To investigate accelerated blood clearance (ABC) induction upon repeated injections of PLGA-PEG nanoparticles as a commonly used polymeric drug... 
Biochemistry, general | Biomedical Engineering | Biomedicine | anti-PEG IgM antibody | PLGA-PEG nanoparticles | Pharmacy | accelerated blood clearance (ABC) | pharmacokinetics | Medical Law | etoposide | Pharmacology/Toxicology | DOXORUBICIN | RATS | BIODISTRIBUTION | CHEMISTRY, MULTIDISCIPLINARY | DISAPPEARANCE | DELIVERY | SURFACE-DENSITY | PLASMA | PHARMACOLOGY & PHARMACY | MICE | CHAIN-LENGTH | POLYETHYLENE-GLYCOL-LIPOSOMES | Nanoparticles - analysis | Injections, Intravenous | Rats, Wistar | Drug Carriers - administration & dosage | Polyethylene Glycols - analysis | Male | Drug Carriers - analysis | Etoposide - blood | Polyglycolic Acid - analysis | Immunoglobulin M - immunology | Antineoplastic Agents, Phytogenic - administration & dosage | Antibodies - analysis | Polyglycolic Acid - metabolism | Lactic Acid - administration & dosage | Lactic Acid - analysis | Antineoplastic Agents, Phytogenic - blood | Polyglycolic Acid - administration & dosage | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Rats | Etoposide - administration & dosage | Polyethylene Glycols - administration & dosage | Animals | Nanoparticles - administration & dosage | Drugs | Care and treatment | Immunoglobulins | Drug delivery systems | Etoposide | Drugstores | Coatings | Vehicles | Nanoparticles | Poisoning | Universities and colleges | Polymer industry | Polymers | Cancer | Blood-brain barrier | Cancer therapies | Pharmaceutical sciences | Index Medicus | Antitumor agents
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2012, Volume 101, Issue 10, pp. 3864 - 3876
Journal Article
Pharmaceutical research, ISSN 1573-904X, 2009, Volume 27, Issue 2, pp. 296 - 302
Accelerated blood clearance (ABC) is induced by repeated injections of PEGylated liposomes... 
Biomedical Engineering | Biochemistry, general | polymeric micelle | Biomedicine | Pharmacy | accelerated blood clearance | Medical Law | Pharmacology/Toxicology | PEGylated liposome | polyethylene glycol (PEG) | gadolinium | Gadolinium | Polymeric micelle | Polyethylene glycol (PEG) | Accelerated blood clearance | STERICALLY STABILIZED LIPOSOMES | CIRCULATION | CONTRAST AGENTS | MRI | REPEATED INJECTIONS | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | PHYSICOCHEMICAL PROPERTIES | POLY(ETHYLENE GLYCOL) | SURFACE | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | Gadolinium - administration & dosage | Polyethylene Glycols - metabolism | Tissue Distribution - physiology | Polymers - administration & dosage | Tissue Distribution - drug effects | Polylysine - analogs & derivatives | Polylysine - administration & dosage | Polyethylene Glycols - pharmacokinetics | Drug Carriers - chemistry | Gadolinium - chemistry | Metabolic Clearance Rate - physiology | Polyethylene Glycols - administration & dosage | Polylysine - pharmacokinetics | Animals | Time Factors | Micelles | Polymers - pharmacokinetics | Polylysine - blood | Female | Polymers - chemistry | Drug Carriers - pharmacokinetics | Gadolinium - blood | Metabolic Clearance Rate - drug effects | Mice | Rare earth metals | Lipids | Universities and colleges | Lysine | Polyethylene glycol | Polyols | Drug delivery systems | Pharmacology | Molecular biology | Polymers | Rodents | Blood
Journal Article
Drug delivery system, ISSN 0913-5006, 2017, Volume 32, Issue 5, pp. 396 - 401
ポリエチレングリコール(PEG)修飾リポソームなどのPEG修飾体に対するaccelerated blood clearance (ABC)現象は、これまでbio-inertと考えられてきたPEGに対する免疫反応であり、PEGに対する抗体の誘導と、この誘導された抗体がその後に投与されるPEG修飾体に結合することに端... 
species difference | PEGylated drug | Anti-PEG antibody | Accelerated blood clearance (ABC) phenomenon | Proteins | Complement activation | Immunology | Immune response | Immunogenicity | Polyethylene glycol | Immune clearance | Antibodies | Liposomes | Bioavailability | Species
Journal Article