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acetaminophen-induced hepatotoxicity (364) 364
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TOXICOLOGICAL SCIENCES, ISSN 1096-6080, 02/2002, Volume 65, Issue 2, pp. 166 - 176
Journal Article
Journal Article
Journal Article
by Chen, J and Wang, ZS and She, MY and Liu, MD and Zhao, ZB and Chen, X and Liu, P and Zhang, SY and Li, JL
ACS APPLIED MATERIALS & INTERFACES, ISSN 1944-8244, 09/2019, Volume 11, Issue 36, pp. 32605 - 32612
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 02/2011, Volume 71, Issue 2, pp. 273 - 282
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2015, Volume 289, Issue 2, pp. 213 - 222
3′-Hydroxyacetanilide or N-acetyl- -aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies demonstrated... 
Protein adducts | Mitochondrial dysfunction | Acetaminophen | 3′-Hydroxyacetanilide (AMAP) | Hepatotoxicity | 3'-Hydroxyacetanilide (AMAP) | NONHEPATOTOXIC POSITIONAL ISOMER | INDUCED OXIDANT STRESS | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | REACTIVE METABOLITES | COVALENT BINDING | INDUCED LIVER-INJURY | CULTURED MOUSE HEPATOCYTES | REGIOISOMER 3'-HYDROXYACETANILIDE | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | 3 '-Hydroxyacetanilide (AMAP) | TERMINAL KINASE ACTIVATION | L-Lactate Dehydrogenase - metabolism | Liver - pathology | Phosphorylation | Species Specificity | Glutathione - metabolism | Mitochondria, Liver - metabolism | Humans | Hepatocytes - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Liver - drug effects | Time Factors | Mitochondrial Proteins - metabolism | Cell Death - drug effects | Chemical and Drug Induced Liver Injury - pathology | Glutamate Dehydrogenase - metabolism | Chemical and Drug Induced Liver Injury - etiology | Hepatocytes - drug effects | Mitochondria, Liver - pathology | Liver - metabolism | Cells, Cultured | Mitochondria, Liver - drug effects | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Acetanilides - toxicity | Protein Binding | Mice | Primary Cell Culture | Proteins | Mitochondrial DNA | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | IMINES | LACTATES | MITOCHONDRIA | ADDUCTS | TOXICITY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | DISULFIDES | LACTATE DEHYDROGENASE | IODIDES | ALANINES | GLUTATHIONE | HAMSTERS | LIVER | LIVER CELLS | PHOSPHOTRANSFERASES | AMINOTRANSFERASES | TRANSGENIC MICE | protein adducts | acetaminophen | mitochondrial dysfunction | hepatotoxicity
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 02/2015, Volume 76, pp. 19 - 26
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 02/2019, Volume 20, Issue 4, p. 993
Paracetamol is responsible for acute liver failure in humans and experimental animals when taken at high doses and transformed into a reactive metabolite by... 
ACETAMINOPHEN-INDUCED HEPATOTOXICITY | OXIDATIVE STRESS | ACTIVATION | Myristica fragrans kernels | liver | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXICITY | NUTMEG | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | NRF2 | HOUTT | MICE | paracetamol | HEME OXYGENASE-1 | heme oxygenase 1
Journal Article
PROTEOMICS, ISSN 1615-9853, 04/2013, Volume 13, Issue 8, pp. 1257 - 1275
Hepatocytes are used widely as a cell model for investigation of xenobiotic metabolism and the toxic mechanism of drugs. Simvastatin is the first statin drug... 
Cell biology | Label‐free protein quantitation | Transcriptomics | Hepatotoxicity | Simvastatin | Label-free protein quantitation | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | STATIN-INDUCED MYOPATHY | APOLIPOPROTEIN-B | MESSENGER-RNA | LIVER-INJURY | METABOLISM | GENE-EXPRESSION | HEPG2 CELLS | MICE | FATTY-ACID SYNTHASE | Simvastatin - adverse effects | Cytochrome P-450 Enzyme System - metabolism | Bile - metabolism | Male | Gene Expression Profiling | Hepatocytes - metabolism | Hepatitis - metabolism | Urea - metabolism | Proteomics - methods | Fatty Acids - metabolism | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Simvastatin - toxicity | Cell Survival - drug effects | Reproducibility of Results | Cells, Cultured | Oxidative Stress - genetics | Rats | Rats, Sprague-Dawley | Blotting, Western | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Proteins - metabolism | NF-E2-Related Factor 2 - metabolism | Software | Metabolic Networks and Pathways - drug effects | Oxidative Stress - drug effects | Chromatography, Liquid - methods | RNA | Cytochrome P-450 | Heat shock proteins | Fatty acids | Cells | Cholesterol | Antilipemic agents | Proteins | Urea | Hypercholesterolemia | Analysis | Physiological aspects | Xenobiotics | Index Medicus | Bile
Journal Article