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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2007, Volume 104, Issue 42, pp. 16480 - 16485
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1108 - 1119
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is... 
PROSTATE | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | PHOSPHORYLATION SITES | CELL BIOLOGY | SYNTHASE | METABOLISM | LIPOGENESIS | AMPK | HEPATIC STEATOSIS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Acetyltransferases - antagonists & inhibitors | Lipid Metabolism - genetics | Pyrimidinones - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Lipid Metabolism - drug effects | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Fatty Acids - biosynthesis | Synthesis | Growth | Cancer cells | Genetic aspects | Models | Research | Lung cancer, Non-small cell | Fatty acids | Carboxylases | Animal models | p53 Protein | Xenotransplantation | Lung | Lung cancer | Pharmacology | LKB1 protein | Allosteric properties | Liability | Acetyl-CoA carboxylase | Xenografts | Carboplatin | Genetic engineering | Inhibition | Dimerization | Viability | Cancer | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 502 - 507
The PII protein is a signal integrator involved in the regulation of nitrogen metabolism in bacteria and plants. Upon sensing of cellular carbon and energy... 
Proteins | Enzymes | Signal transduction | Protein metabolism | Chloroplasts | Gene expression regulation | Nitrogen | Resins | Plastids | Chromatography | Arabidopsis thaliana | Biotin carboxy | PII protein organic acids fatty acid metabolism | Carrier protein | ARABIDOPSIS-THALIANA | L-GLUTAMATE KINASE | fatty acid metabolism | MULTIDISCIPLINARY SCIENCES | PUTATIVE NITROGEN SENSOR | organic acids | N-ACETYLGLUTAMATE-KINASE | SIGNAL-TRANSDUCTION PROTEIN | COMPLEX-FORMATION | PII protein | HIGHER-PLANTS | BIOSYNTHESIS | P-II | ARGININE | biotin carboxyl carrier protein | Arabidopsis Proteins - genetics | Chloroplasts - enzymology | Arabidopsis - enzymology | Arabidopsis - cytology | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Acetyl Coenzyme A - metabolism | Acetyl-CoA Carboxylase - genetics | Protein Subunits - metabolism | Arabidopsis Proteins - metabolism | Arabidopsis Proteins - chemistry | PII Nitrogen Regulatory Proteins - metabolism | PII Nitrogen Regulatory Proteins - genetics | Recombinant Fusion Proteins - genetics | Biotin - metabolism | Protein Subunits - chemistry | Ketoglutaric Acids - metabolism | Plant Leaves - enzymology | Acetyl-CoA Carboxylase - metabolism | Plant Leaves - ultrastructure | Acetyl-CoA Carboxylase - chemistry | Protein Subunits - genetics | Physiological aspects | Cellular proteins | Biotin | Cellular signal transduction | Research | Carboxylases | Chlorophyll | Bacteria | Effects | Mass spectrometry | Adenosine triphosphatase | Index Medicus | Biological Sciences
Journal Article
Journal Article