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The Journal of biological chemistry, ISSN 1083-351X, 2019, Volume 294, Issue 32, pp. 12020 - 12039
Journal Article
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 10, pp. 1108 - 1119
.... This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target... 
PROSTATE | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | PHOSPHORYLATION SITES | CELL BIOLOGY | SYNTHASE | METABOLISM | LIPOGENESIS | AMPK | HEPATIC STEATOSIS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Acetyltransferases - antagonists & inhibitors | Lipid Metabolism - genetics | Pyrimidinones - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Lipid Metabolism - drug effects | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Fatty Acids - biosynthesis | Synthesis | Growth | Cancer cells | Genetic aspects | Models | Research | Lung cancer, Non-small cell | Fatty acids | Carboxylases | Enzymes | Genetically modified organisms | Genetic engineering | Tumor proteins | Tumors | Animal models | p53 Protein | Xenotransplantation | Lung cancer | Non-small cell lung carcinoma | Pharmacology | LKB1 protein | Allosteric properties | Liability | Acetyl-CoA carboxylase | Lungs | Xenografts | Carboplatin | Inhibition | Dimerization | Viability | Cancer
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 2012, Volume 70, Issue 5, pp. 863 - 891
Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA carboxylase (PCC... 
Biochemistry, general | Obesity | Fatty acid metabolism | Carbohydrate metabolism | Metabolic syndrome | Lactic acidemia | Amino acid metabolism | Biomedicine general | Propionic acidemia | Cell Biology | Life Sciences | 3-methylcrotonylglycinuria | Life Sciences, general | Antibiotics | Diabetes | Drug discovery | Cancer | FATTY-ACID SYNTHESIS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACETYL-COA CARBOXYLASE | TERPENE UTILIZATION ATU | CELL BIOLOGY | COENZYME-A-CARBOXYLASE | PARENTAL SPECIES CLONING | CARBOXYLTRANSFERASE DOMAIN | ACCASE-INHIBITING HERBICIDES | AUREUS PYRUVATE-CARBOXYLASE | Carbon-Nitrogen Ligases - metabolism | Humans | Models, Molecular | Fatty Acid Synthase, Type II - metabolism | Methylmalonyl-CoA Decarboxylase - chemistry | Methylmalonyl-CoA Decarboxylase - metabolism | Pyruvate Carboxylase - metabolism | Pyruvate Carboxylase - chemistry | Carbon-Carbon Ligases - metabolism | Animals | Fatty Acid Synthase, Type II - chemistry | Biotin - metabolism | Protein Conformation | Carbon-Carbon Ligases - chemistry | Carbon-Nitrogen Ligases - chemistry | Acetyl-CoA Carboxylase - metabolism | Acetyl-CoA Carboxylase - chemistry | Type 2 diabetes | Herbicides | Urea | Care and treatment | Ligases | Physiological aspects | Amino acids | Biotin | Fatty acids | Proteins | Enzymes | Cellular biology | Metabolic disorders | metabolic syndrome | propionic acidemia | lactic acidemia | drug discovery | carbohydrate metabolism | fatty acid metabolism | cancer | diabetes | antibiotics | obesity | amino acid metabolism
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2018, Volume 68, Issue 6, pp. 2197 - 2211
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 558, Issue 7710, pp. 470 - 474
Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis(1,2... 
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