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Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 5, pp. 2422 - 2434
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 12/2013, Volume 1831, Issue 12, pp. 1657 - 1664
Acid ceramidase (AC), EC 3.5.1.23, a lysosomal enzyme, catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid. Because... 
Ceramide | Acid ceramidase | Tamoxifen | Lysosomal protease | Antiestrogen | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOSPHINGOLIPID METABOLISM | PHASE-II | CONFERS RESISTANCE | REVERSE MULTIDRUG-RESISTANCE | HIGH-DOSE TOREMIFENE | CELL BIOLOGY | BREAST-CANCER | COLON-CANCER | BIOPHYSICS | PROSTATE-CANCER | IN-VIVO | UP-REGULATION | Sphingosine | Cancer cells | Cathepsins | Permeability | Fatty acids | Cancer
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 2006, Volume 1758, Issue 12, pp. 2133 - 2138
Acid ceramidase ( -acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free... 
Ceramide | Acid ceramidase | Farber disease | Apoptosis | Cancer | MUTATION ANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS-INDUCED APOPTOSIS | apoptosis | IDENTIFICATION | DEFICIENCY | CELL-DEATH | ceramide | BIOPHYSICS | SPHINGOMYELINASE GENE | PROSTATE-CANCER | FARBER-DISEASE | cancer | OVEREXPRESSION PREVENTS | TUMOR-GROWTH | acid ceramidase | Enzymes
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2011, Volume 17, Issue 1, pp. 55 - 63
Journal Article
Journal Article
Journal Article
Oncology Reports, ISSN 1021-335X, 10/2017, Volume 38, Issue 4, pp. 1932 - 1940
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 987 - 992
Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the... 
RESISTANCE | 5-FLUOROURACIL | CHEMISTRY, MEDICINAL | INVITRO | DRUGS | carmofur | glioblastoma | S1P | acid ceramidase inhibitors | radiation | benzoxazolone carboxamides | sphingosine-1-phosphate | sphingosine | radioresistance | acid ceramidase
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 05/2019, Volume 141, Issue 19, pp. 7736 - 7742
Acid ceramidase (AC) hydrolyzes ceramides into sphingoid bases and fatty acids. The enzyme is overexpressed in several types of cancer and Alzheimer's disease,... 
PHARMACOLOGICAL CHAPERONES | DISEASE | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | DEFICIENCY | ACTIVITY-BASED PROBES | TRANSPLANTATION
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2015, Volume 52, pp. 163 - 172
Abstract Background Acid ceramidase (AC), a key enzyme in ceramide metabolism, plays a role in cancer progression and resistance to therapy. However, the role... 
Hematology, Oncology and Palliative Medicine | Ceramide | Head and neck cancer | Acid ceramidase | Cell death | Cisplatin | PROSTATE | CHEMOTHERAPY | INVASION | INHIBITION | FASL | ONCOLOGY | RESISTANCE | MELANOMA-CELLS | UP-REGULATION | EXPRESSION | Acid Ceramidase - antagonists & inhibitors | Apoptosis - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Male | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Acid Ceramidase - metabolism | Cell Survival - drug effects | Carcinoma, Squamous Cell - enzymology | Acid Ceramidase - genetics | Ceramides - metabolism | Enzyme Inhibitors - pharmacology | Head and Neck Neoplasms - drug therapy | Cisplatin - pharmacology | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mice, Inbred BALB C | RNAi Therapeutics | Cell Cycle - drug effects | Antimitotic agents | Enzymes | Chemotherapy | Physiological aspects | Development and progression | Antineoplastic agents | Cancer
Journal Article