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Science signaling, ISSN 1937-9145, 2017, Volume 10, Issue 493, p. eaal5241
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to... 
GENE-RELATED PEPTIDE | RNA-SEQ | DIETARY N-3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFLAMMATORY HYPERALGESIA | SPINAL-CORD | PSYCHOLOGICAL DISTRESS | RANDOMIZED-TRIAL | SKIN | RAT SENSORY NEURONS | ESSENTIAL FATTY-ACIDS | CELL BIOLOGY | Inflammation - pathology | Skin - cytology | Linoleic Acid - metabolism | Skin - metabolism | Humans | Middle Aged | Male | Pain - metabolism | Receptors, Calcitonin Gene-Related Peptide - metabolism | Case-Control Studies | Inflammation - metabolism | Psoriasis - pathology | Inflammation - drug therapy | Pain - drug therapy | Pruritus - drug therapy | Systems Analysis | Psoriasis - metabolism | Aged, 80 and over | Adult | Female | Sensory Receptor Cells - metabolism | Skin - pathology | Psoriasis - drug therapy | Rats | Linoleic Acid - chemistry | Pain - pathology | Rats, Sprague-Dawley | Pruritus - metabolism | Animals | Sensory Receptor Cells - cytology | Sensory Receptor Cells - drug effects | Aged | Mice | Nociceptors - metabolism | Pruritus - pathology | In Vitro Techniques | Headache | Capsaicin | Pain | Dorsal root ganglia | Calcitonin | Rodents | Scratching | Skin diseases | Ion channels | Lesions | Pain sensitivity | Scratching behavior | Pain perception | Hypersensitivity | Mass spectroscopy | Pharmacology | Dietary intake | Inflammation | Injection | Derivatives | Gene expression | Fatty acids | Linoleic acid | Calcitonin gene-related peptide | Diet | Skin | Mass spectrometry
Journal Article
Anais da Academia Brasileira de Ciencias, ISSN 0001-3765, 2018, Volume 90, Issue 2, pp. 1945 - 1954
Thirteen natural products derivatives of hydroxyl amide class, three described for the first time, were synthesized by reaction of three indole acids and... 
Acetylcholinesterase inhibition | Indole acid derivatives | Antimicrobial activity | 3,4,5-trime-thoxybenzoic acid derivatives | 3,4,5-trimethoxybenzoic acid derivatives | acetylcholinesterase inhibition | antimicrobial activity | indole acid derivatives
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2017, Volume 56, Issue 38, pp. 11545 - 11548
The first highly enantioselective iridium‐catalyzed allylic alkylation that provides access to products bearing an allylic all‐carbon quaternary stereogenic... 
iridium | quaternary stereocenter | carboxylic acid derivatives | allylic alkylation | umpolung | SUBSTITUTION | REAGENTS | CHEMISTRY, MULTIDISCIPLINARY | CARBON STEREOGENIC CENTERS | DIASTEREO | ORIGINS | STEREOCENTERS | CONSTRUCTION | ESTERS | REGIO | ARYL
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2013, Volume 135, Issue 26, pp. 9588 - 9591
Herein we report a metal-free method for the direct anti-Markovnikov hydroamination of unsaturated amines. Irradiation of the amine substrates with visible... 
PHOTOCHEMICAL NUCLEOPHILE | ACID DERIVATIVES | INTERMOLECULAR HYDROAMINATION | ASYMMETRIC HYDROAMINATION | INTRAMOLECULAR HYDROAMINATION | PRIMARY AMINES | SECONDARY ALKYLAMINES | C-H FUNCTIONALIZATION | OLEFIN COUPLING REACTIONS | CHEMISTRY, MULTIDISCIPLINARY | UNACTIVATED ALKENES
Journal Article
Chemical science (Cambridge), ISSN 2041-6539, 2012, Volume 3, Issue 3, pp. 633 - 658
Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct... 
ASYMMETRIC CATALYSIS | BRONSTED ACID | DOUBLE-ACTIVATION METHOD | COOPERATIVE CATALYSIS | MILD ELECTROPHILIC TRIFLUOROMETHYLATION | AMINO-ACID DERIVATIVES | TRANSITION-METAL | PHASE-TRANSFER CATALYST | ALLYLIC ALKYLATION | ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 12/2016, Volume 45, Issue 24, pp. 6685 - 6697
The reduction of amides gives access to a wide variety of important compounds such as amines, imines, enamines, nitriles, aldehydes and alcohols. The... 
SELF-ENCAPSULATION | METAL-FREE REDUCTION | SECONDARY AMIDES | AMINES | HYDROSILANE REDUCTION | SILANE REDUCTION | TERTIARY AMIDES | SELECTIVE REDUCTION | RHODIUM-CATALYZED REDUCTION | CHEMISTRY, MULTIDISCIPLINARY | CARBOXYLIC-ACID DERIVATIVES
Journal Article
Journal of the Brazilian Chemical Society, ISSN 0103-5053, 06/2018, Volume 29, Issue 6, pp. 1286 - 1290
Journal Article
Tetrahedron, ISSN 0040-4020, 2011, Volume 67, Issue 38, pp. 7195 - 7210
The indole alkaloids, ranging from lysergic acid to vincristine, have long inspired organic synthesis chemists. Interest in developing new methods for indole... 
INDOLE-3-CARBOXYLIC ACID-DERIVATIVES | 2-SUBSTITUTED INDOLES | ONE-POT SYNTHESIS | CATALYZED SYNTHESIS | REGIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | ALLENE INTRAMOLECULAR CYCLOADDITION | 2,3-DISUBSTITUTED INDOLES | SUBSTITUTED INDOLES | C-H AMINATION | 3-SUBSTITUTED INDOLES | LSD (Drug)
Journal Article
Cancer Biology & Therapy, ISSN 1555-8576, 2014, Volume 9, Issue 2, pp. 109 - 110
Commentary to: Down-regulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | NAC | Reactive oxygen species | Glycyrrhenitic acid derivatives | Triterpenoids | Apoptosis | Glutathione | CANCER-CELLS | OXIDATIVE STRESS | glutathione | triterpenoids | PROTEASOME INHIBITOR PS-341 | apoptosis | INDUCTION | BORTEZOMIB | glycyrrhenitic acid derivatives | TRITERPENOID CDDO | ONCOLOGY | PATHWAY | BLOCKS | reactive oxygen species
Journal Article