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Nature Genetics, ISSN 1061-4036, 12/2014, Volume 47, Issue 1, pp. 31 - 38
Cushing's disease is caused by corticotroph adenomas of the pituitary. To explore the molecular mechanisms of endocrine autonomy in these tumors, we performed... 
UBPY | ENDOSOMES | DOMAIN | PROTEIN | EPIDERMAL-GROWTH-FACTOR | GENETICS & HEREDITY | UBIQUITYLATION | DEGRADATION | RECEPTOR DOWN-REGULATION | ENDOCYTIC TRAFFICKING | PITUITARY-ADENOMAS | Adenoma - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Cercopithecus aethiops | Endosomal Sorting Complexes Required for Transport - genetics | Molecular Sequence Data | Pituitary Neoplasms - complications | ACTH-Secreting Pituitary Adenoma - complications | Pituitary ACTH Hypersecretion - genetics | ACTH-Secreting Pituitary Adenoma - genetics | Receptor, Epidermal Growth Factor - metabolism | Pituitary Neoplasms - secretion | Neoplasm Proteins - genetics | Pro-Opiomelanocortin - genetics | Amino Acid Sequence | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Neoplasms - genetics | Ubiquitin Thiolesterase - physiology | Pituitary Neoplasms - metabolism | Ubiquitin Thiolesterase - genetics | 14-3-3 Proteins - metabolism | Adrenocorticotropic Hormone - secretion | Sequence Homology, Amino Acid | Exome - genetics | Sequence Alignment | Animals | Endopeptidases - genetics | ACTH-Secreting Pituitary Adenoma - secretion | Pro-Opiomelanocortin - biosynthesis | Mutation | COS Cells | Endosomal Sorting Complexes Required for Transport - physiology | Endopeptidases - physiology | Gene mutations | Cushing syndrome | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Health aspects | Risk factors | Pituitary gland | Kinases | Rodents | Genes | Tumors | Index Medicus
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 2016, Volume 231, Issue 2, pp. 135 - 145
Somatostatin analogs (SSA) are the mainstay of pharmacological treatment for pituitary adenomas. However, some patients escape from therapy with octreotide, a... 
Somatostatin | Gene expression | Pituitary | Cell signaling | Pituitary adenoma | pituitary | SOMATOSTATIN ANALOG SOM230 | AGGRESSIVE FEATURES | MEDICAL-TREATMENT | CUSHINGS-DISEASE | QUANTITATIVE-ANALYSIS | pituitary adenoma | RECEPTOR SUBTYPES | GROWTH-HORMONE | somatostatin | cell signaling | ENDOCRINOLOGY & METABOLISM | ACTH RELEASE | gene expression | ADENOMAS | GENE-EXPRESSION LEVELS | ACTH-Secreting Pituitary Adenoma - drug therapy | Humans | Drug Resistance, Neoplasm | Male | Pituitary Gland - secretion | Somatostatin - pharmacology | Prolactinoma - metabolism | Receptors, Somatostatin - genetics | Antineoplastic Agents, Hormonal - adverse effects | Growth Hormone-Secreting Pituitary Adenoma - metabolism | Pituitary Neoplasms - secretion | Receptors, Somatostatin - metabolism | Neoplasm Proteins - genetics | Prolactinoma - pathology | Cell Survival - drug effects | Pituitary Neoplasms - drug therapy | ACTH-Secreting Pituitary Adenoma - secretion | Calcium Signaling - drug effects | Adenoma - secretion | Growth Hormone-Secreting Pituitary Adenoma - pathology | Pituitary Gland - metabolism | Somatostatin - adverse effects | Prolactinoma - secretion | Neoplasm Proteins - metabolism | Adenoma - metabolism | Receptors, Somatostatin - agonists | Protein Isoforms - metabolism | Protein Isoforms - agonists | Adenoma - drug therapy | Female | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Prolactinoma - drug therapy | Somatostatin - analogs & derivatives | Antineoplastic Agents, Hormonal - pharmacology | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Gland - pathology | Cells, Cultured | Octreotide - adverse effects | Pituitary Neoplasms - pathology | Pituitary Neoplasms - metabolism | Octreotide - pharmacology | Growth Hormone-Secreting Pituitary Adenoma - drug therapy | Neoplasm Proteins - agonists | Adenoma - pathology | Growth Hormone-Secreting Pituitary Adenoma - secretion | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | Protein Isoforms - genetics | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2012, Volume 97, Issue 4, pp. E663 - E670
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2836 - 2843
Context: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have been recently identified as the most common genetic alteration in patients... 
TARGET | UBPY | ADOLESCENTS | ENDOCRINOLOGY & METABOLISM | RESISTANCE | CANCER | EGFR | DEUBIQUITINATING ENZYMES | PITUITARY-ADENOMAS | CHILDREN | Adenoma - surgery | Prognosis | Adenoma - genetics | Humans | Child, Preschool | Endosomal Sorting Complexes Required for Transport - genetics | Hydrocortisone - metabolism | Male | Adenoma - metabolism | Pituitary ACTH Hypersecretion - genetics | ACTH-Secreting Pituitary Adenoma - genetics | ACTH-Secreting Pituitary Adenoma - surgery | Pituitary ACTH Hypersecretion - surgery | Female | Retrospective Studies | Neuroendoscopy | Child | Adrenocorticotropic Hormone - metabolism | Cavernous Sinus - pathology | Pituitary ACTH Hypersecretion - pathology | ACTH-Secreting Pituitary Adenoma - metabolism | Neoplasm Invasiveness | Tumor Burden | Ubiquitin Thiolesterase - genetics | Endopeptidases - genetics | Pituitary ACTH Hypersecretion - metabolism | Adolescent | Age of Onset | Adenoma - pathology | Neoplasm Recurrence, Local - genetics | Mutation | ACTH-Secreting Pituitary Adenoma - pathology | Ubiquitin | Pediatrics | Nervous system diseases | Ubiquitin-specific proteinase | Nucleotide sequence | Hydrocortisone | Gene deletion | Patients | 14-3-3 protein | Adrenocorticotropic hormone | Clonal deletion | Sinus | Pituitary | Deletion | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 02/2016, Volume 174, Issue 2, pp. 213 - 226
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 03/2016, Volume 174, Issue 3, pp. 307 - 314
Journal Article
Clinical Endocrinology, ISSN 0300-0664, 02/2015, Volume 82, Issue 2, pp. 260 - 266
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2013, Volume 98, Issue 12, pp. E1880 - E1890
Context: Corticotroph pituitary adenomas often highly express the dopamine 2 receptor (D2R) and somatostatin receptor subtype 5 (sst5). The sst2 expression is... 
POTENT INHIBITOR | OCTREOTIDE | ACTH-SECRETION | INTERNALIZATION | GLUCOCORTICOIDS | CORTICOTROPH ADENOMAS | ENDOCRINOLOGY & METABOLISM | ADRENOCORTICOTROPIN SECRETION | NELSONS SYNDROME | TUMOR-CELLS | PITUITARY-ADENOMAS | ACTH-Secreting Pituitary Adenoma - drug therapy | Pituitary Gland - metabolism | Humans | Middle Aged | Hydrocortisone - secretion | Hydrocortisone - urine | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Receptors, Dopamine D2 - metabolism | ACTH-Secreting Pituitary Adenoma - physiopathology | Somatostatin - pharmacology | Receptors, Somatostatin - genetics | Young Adult | Receptors, Somatostatin - agonists | Protein Isoforms - metabolism | Adult | Female | Receptors, Somatostatin - antagonists & inhibitors | Adrenal Glands - secretion | Antineoplastic Agents - pharmacology | Receptors, Somatostatin - metabolism | Tumor Cells, Cultured | Adrenal Glands - drug effects | Neoplasm Proteins - genetics | Pituitary ACTH Hypersecretion - prevention & control | Dopamine Agonists - pharmacology | Somatostatin - analogs & derivatives | Pituitary ACTH Hypersecretion - etiology | ACTH-Secreting Pituitary Adenoma - metabolism | Pituitary Gland - pathology | Receptors, Dopamine D2 - genetics | Gene Expression Regulation - drug effects | Neoplasm Proteins - agonists | Adolescent | Aged | Dopamine D2 Receptor Antagonists | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | Protein Isoforms - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 37 - 46
Adrenocorticotropic hormone (ACTH) production by pituitary corticotroph adenomas is the main cause of Cushing’s disease. A drug that targets pituitary... 
POMC | ACTH | Treatment | Cushing’s disease | Pituitary tumor | Cushing's disease | SOMATOSTATIN ANALOGS | ANTERIOR-PITUITARY | MEDICAL-TREATMENT | CUSHINGS-DISEASE | PASIREOTIDE | DIFFERENTIAL REGULATION | PITUITARY-ADENOMAS | CELL BIOLOGY | MESSENGER-RNA | ENDOCRINOLOGY & METABOLISM | SECRETION | RECEPTORS | Adrenocorticotropic Hormone - antagonists & inhibitors | ACTH-Secreting Pituitary Adenoma - drug therapy | Corticotrophs - drug effects | Neoplasm Transplantation | RNA, Small Interfering - genetics | Pituitary Gland - metabolism | Humans | Male | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Somatostatin - pharmacology | Receptors, Somatostatin - genetics | ACTH-Secreting Pituitary Adenoma - genetics | Receptors, Somatostatin - antagonists & inhibitors | Receptors, Somatostatin - metabolism | Pro-Opiomelanocortin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Corticotrophs - metabolism | Somatostatin - analogs & derivatives | ACTH-Secreting Pituitary Adenoma - metabolism | Corticotrophs - pathology | Pituitary Gland - pathology | Pituitary Neoplasms - genetics | RNA, Messenger - genetics | Pituitary Neoplasms - pathology | Adrenocorticotropic Hormone - biosynthesis | Pituitary Neoplasms - metabolism | Pro-Opiomelanocortin - metabolism | Animals | Pituitary Neoplasms - drug therapy | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | ACTH-Secreting Pituitary Adenoma - pathology | Pituitary Gland - drug effects | RNA, Small Interfering - metabolism | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2013, Volume 110, Issue 21, pp. 8555 - 8560
Cushing disease (CD) is a life-threatening disorder attributed to excess pituitary tumor-derived adrenocorticotrophic hormone (ACTH) and adrenal steroid... 
Cell growth | Phosphorylation | Pituitary neoplasms | Secretion | Plasmids | Cell lines | Pituitary ACTH hypersecretion | Mice | Orphan nuclear receptors | Tumors | MANAGEMENT | ACID | PHOSPHORYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | MODULATOR | EXPRESSION | Transcriptional Activation - genetics | Cell Proliferation | Receptors, Steroid - metabolism | Humans | Neoplasm Proteins - metabolism | ACTH-Secreting Pituitary Adenoma - therapy | Adrenocorticotropic Hormone - genetics | Pituitary ACTH Hypersecretion - genetics | ACTH-Secreting Pituitary Adenoma - genetics | Receptors, Thyroid Hormone - genetics | Response Elements - genetics | Corticosterone - secretion | Neoplasm Proteins - genetics | Pro-Opiomelanocortin - genetics | Pituitary ACTH Hypersecretion - therapy | Gene Expression Regulation, Neoplastic - genetics | Pituitary ACTH Hypersecretion - pathology | ACTH-Secreting Pituitary Adenoma - metabolism | Corticosterone - genetics | Adrenocorticotropic Hormone - secretion | Receptors, Thyroid Hormone - metabolism | Animals | Pituitary ACTH Hypersecretion - metabolism | Receptors, Steroid - genetics | Pro-Opiomelanocortin - biosynthesis | Cell Line, Tumor | ACTH-Secreting Pituitary Adenoma - pathology | Physiological aspects | Pituitary gland | Research | Hydrocortisone | Health aspects | Causes and theories of causation | Diseases | Rodents | Genetics | T cell receptors | Binding sites | Index Medicus | Biological Sciences
Journal Article